In-transit filia of a melanoma 37 years after primary excision.

J Eur Acad Dermatol Venereol. 2008 Jul 7;

Authors: Schilling B, Freise J, Dissemond J

PMID: 18631202 [PubMed - as supplied by publisher]

Rowell syndrome - case report and review of the literature.

Dermatol Online J. 2008;14(3):15

Authors: Duarte AF, Mota A, Pereira M, Baudrier T, Azevedo F

Rowell syndrome is a rare distinctive entity first described in 1963 by Rowell and coworkers. It consists in erythema multiforme-like lesions associated with lupus erythematosus. Zeitouni et al. recently redefined the major and minor diagnostic criteria. Major criteria are lupus erythematosus, erythema multiforme-like lesions and speckled pattern of antinuclear antibody. Minor criteria are chilblains, positive anti-La (SS-B) or anti-Ro (SS-A) antibody and reactive rheumatoid factor. We report a case of a 63-year-old woman, with no previous history of lupus erythematosus, who developed erythema multiforme-like lesions and laboratory findings consistent with Rowell syndrome.

PMID: 18627716 [PubMed - in process]

Unusual presentation of progressive systemic sclerosis.

Mymensingh Med J. 2008 Jul;17(2):192-6

Authors: Chowdhury SU, Miah MA, Mahmud MI, Talukder SI, Islam MN, Islam N

A female 38 years old, housewife, presented to the Department of Dermatology and Venereology, Mymensingh Medical College Hospital (MMCH) on 08.04.07 with the complaints of i) pain and reduced movement of hand, knee, shoulder and neck joints for 1 year and 9 months ii) tightness of skin over face, neck, limbs and trunk for 1 year and 6 months iii) patchy depigmentation over same areas for 1 year and 3 months iv) deformity of hands with flexion contractures for 6 months and v) dysphagia to solid food for 3 months. She had no complaints of Raynaud's phenomenon. On general examination, she was ill looking, anemic and nutritionally poor. Examination of integumentary system showed smooth, shiny, thick, hard and hidebound skin with pigmentary alteration of 'salt and pepper' appearance over fingers, hands, limbs, face, neck and trunk. Hands appear claw like but more on the right side than the left and there were no other obvious changes suggestive of digital ischaemia (atrophy, ulceration, scarring, gangrene etc). Face has got suggestive features of scleroderma. Examination of the respiratory system showed restriction of chest movement and reduced expansibility of chest wall. No other abnormality was found on examination of other systems. Laboratory investigations showed histopathology typical of scleroderma. X-ray of hands and feet showed suggestive changes, lung function test-showed restrictive lung disease. Barium swallow x-ray of esophagus in supine position showed mild dilation of lower oesophagus. But serology was non-reactive (negative ANA, Negative RA test, Negative VDRL). So, she was diagnosed as a case of progressive systemic sclerosis (PSS) with some atypicality.

PMID: 18626457 [PubMed - in process]

Lack of association between the promoter polymorphisms at positions -238 and -308 of the tumour necrosis factor alpha gene and acne vulgaris in Polish patients.

J Eur Acad Dermatol Venereol. 2008 Jun 26;

Authors: Sobjanek M, Zabłotna M, Nedoszytko B, Sokołowska-Wojdyło M, Włodarkiewicz A

PMID: 18624881 [PubMed - as supplied by publisher]

Wolf's isotopic response: large annular polycyclic lichen planus occurring on healed lesions of dermatophytosis.

J Eur Acad Dermatol Venereol. 2008 Jun 26;

Authors: Ghosh S, Bandyopadhyay D, Chatterjee G, Saha D

PMID: 18624876 [PubMed - as supplied by publisher]

Expression of activation inducer molecule (CD69) on CD3(3)CD8(3) T lymphocytes in children with atopic dermatitis correlates with SCORAD but not with the age of patients.

J Eur Acad Dermatol Venereol. 2008 Jun 26;

Authors: Chernyshov P

PMID: 18624867 [PubMed - as supplied by publisher]

Giant skin tags on unusual locations.

J Eur Acad Dermatol Venereol. 2008 Jul 3;

Authors: Ghosh S, Bandyopadhyay D, Chatterjee G, Bar C

PMID: 18624850 [PubMed - as supplied by publisher]

Lifetime prevalence fluctuations of common bacterial skin infections.

J Eur Acad Dermatol Venereol. 2008 Jul 3;

Authors: Kyriakis K, Palamaras I

PMID: 18624848 [PubMed - as supplied by publisher]

Surface morphology and mechanical properties of fibroblasts from scleroderma patients.

J Cell Mol Med. 2008 Jun 27;

Authors: Reich A, Meurer M, Eckes B, Friedrichs J, Muller DJ

Overproduction of extracellular matrix components by fibroblasts plays a key role in the pathogenesis of scleroderma. To investigate whether these functional alterations are accompanied by changes in the mechanical properties and morphology of fibroblast atomic force microscopy was applied to dermal fibroblasts derived either from scleroderma patients or from healthy donors. No significant morphological differences could be observed among the different cell strains showing long cytoskeleton fibres similar in length and irregularly distributed protrusions on the cell surface. In contrast, significant differences in cellular stiffness of dermal fibroblasts derived from scleroderma lesions were detected. Compared to fibroblasts from healthy donors, diseased cells were characterized by a reduced elastic constant both when the global and local mechanical properties were probed. The altered stiffness of scleroderma fibroblasts may be important in the pathogenesis of the disease as it could lead to the abnormal response of fibroblasts to mechanical stimuli.

PMID: 18624756 [PubMed - as supplied by publisher]

Radiocontrast media-associated exanthema: Identification of cross-reactivity and tolerability by allergologic testing.

Eur J Radiol. 2008 Jul 10;

Authors: Seitz CS, Pfeuffer P, Raith P, Bröcker EB, Trautmann A

BACKGROUND: All iodinated radiocontrast media (RCM) may cause hypersensitivity reactions, either immediate-type within 5-10min of RCM injection or delayed-type, which become apparent more than 1h after RCM exposure. Delayed-type hypersensitivity to RCM may pose a problem for future radiologic investigations because due to possible immunological cross-reactivity all iodinated RCM are usually avoided. OBJECTIVE: The aim of this study was not only to identify the causal RCM for the exanthema but also to demonstrate that patients may receive alternative iodinated RCM despite a history of RCM-induced allergic exanthema. METHODS: We evaluated 32 patients with a history of exanthema after RCM application using standardized patch, prick and intradermal skin testing. In case of positive skin tests intravenous challenges with skin-test-negative RCM were performed to identify non-ionic monomer RCM which are tolerated. RESULTS: In 6 out of 32 patients skin tests strongly suggested a delayed-type non-IgE-mediated allergic hypersensitivity to the RCM iomeprol (3 x), iopromide (2x), and iopamidol. In 4 patients alternative non-ionic monomer RCM (2x iosarcol, iopromide, and iomeprol) were identified by controlled challenge tests. CONCLUSIONS: The evaluation of patients with RCM-associated exanthema should always include appropriate skin tests ensuring that patients with a delayed-type allergic RCM-induced exanthema are not missed. Moreover, allergologic testing may identify alternative RCM of the group of non-ionic monomers, which are tolerated in future radiologic investigations.

PMID: 18620831 [PubMed - as supplied by publisher]

Expression of selected integrins and selectins in bullous pemphigoid.

Mediators Inflamm. 2007;2007:31051

Authors: Zebrowska A, Sysa-Jedrzejowska A, Wagrowska-Danilewicz M, Joss-Wichman E, Erkiert-Polguj A, Waszczykowska E

Blister development in bullous pemphigoid (BP) results from destruction of hemidesmosomes and basement membrane components within the dermoepidermal junction by autoantibodies. Adhesion molecules can take part in pathogenesis of this disease. The aim of the study was to determine the localization and expression of L- and E-selectins and beta1, beta3, and beta4 integrins by immunohistochemistry in skin lesions of 21 patients with BP, compared with 10 healthy subjects. Expression of L and E selectins and beta1, beta3 integrins was detected mainly in basal keratinocytes and in inflammatory infiltrates in the dermis, expression of beta4 integrin was irregular and was detected mainly in dermal part of the blister, while in the control group only weak and single expression of the examined molecules was detected in basal keratinocytes and endothelium cells. The obtained results reveal the important role of selected selectins and integrins in development of skin lesions in BP.

PMID: 17515951 [PubMed - indexed for MEDLINE]