An autologous or commercial tissue adhesive containing
fibrinogen and
thrombin.
The commercial product is a two component system from human plasma that contains
more than fibrinogen and thrombin. The first component contains highly concentrated fibrinogen,
Factor VIII,
fibronectin, and traces of other plasma proteins. The second component contains
thrombin,
calcium chloride, and antifibrinolytic agents such as
aprotinin. Mixing of the two
components promotes clotting and the formation and cross-linking of fibrin.
The tissue adhesive is used for tissue sealing, hemostasis, and wound healing.
Chuansumrit A, Suwannuraks M, Sri-Udomporn N, Pongtanakul B, Worapongpaiboon S.
Recombinant activated factor VII combined with local measures in preventing bleeding from invasive dental procedures in patients with Glanzmann thrombasthenia. (Blood Coagul Fibrinolysis. 2003 Feb;14(2):187-90.)
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Ren W, Yang L, Chen X, Li Y.
The effect of fibrin sealant on dental pulp for pulp capping in experimental dogs. (Hua Xi Kou Qiang Yi Xue Za Zhi. 2000 Dec;18(6):380-2. Chinese.)
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Mankad PS, Codispoti M.
The role of fibrin sealants in hemostasis. (Am J Surg. 2001 Aug;182(2 Suppl):21S-28S.)
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Halfpenny W, Fraser JS, Adlam DM.
Comparison of 2 hemostatic agents for the prevention of postextraction hemorrhage in patients on anticoagulants. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Sep;92(3):257-9.)
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Suwannuraks M, Chuansumrit A, Sriudomporn N.
The use of fibrin glue as an operative sealant in dental extraction in bleeding disorder patients. (Haemophilia. 1999 Mar;5(2):106-8.)
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Bodner L, Weinstein JM, Baumgarten AK.
Efficacy of fibrin sealant in patients on various levels of oral anticoagulant undergoing oral surgery. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998 Oct;86(4):421-4.)
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Yokoyama T, Tatemoto Y, Osaki T.
Hemostatic treatment after tooth extraction in a patient with factor V deficiency. (Oral Dis. 1997 Sep;3(3):196-8.)
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