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   Drugs and Chemicals /  D   Danazol (Danocrine, Cyclomen)

A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.


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   Related Disorders   


Endometriosis
A condition in which functional endometrial tissue is present outside the uterus. It is often confined to the pelvis involving the ovary, the ligaments, cul-de-sac, and the uterovesical peritoneum.
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 Pharmacologic Action
  • Estrogen Antagonist
    Compounds which inhibit or antagonize the action or biosynthesis of estrogenic compounds.



Free Full Text 05 Jul 2008
Endometriosis and its treatment with danazol or lupron in relation to ovarian cancer
It has been hypothesized that circulating androgens may be involved in the development of ovarian cancer. The androgenic medication, danazol, and the antiandrogenic medications, leuprolide and nafarelin, are commonly used in the treatment of endometriosis. We assessed the associations between the use of these medications and ovarian cancer
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Danazol induced hepatocellular carcinoma
Danazol, an inhibitor of pituitary gonadotropin with weak androgenic effects, is currently used in the treatment of endometriosis, hereditary angio-oedema, systemic lupus erythematosus, and idiopathic thrombocytopenic purpura (ITP). Its hepatological side-effects have been well documented. These include reversible elevations of serum aminotransferase values, cholestatic hepatitis,hepatic peliosis and hepatocellular adenomas. Only a few cases of danazol-associated hepatocellular carcinoma (HCC) have been described. We report a new case.
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Danazol treatment of idiopathic myelofibrosis with severe anemia
Severe anemia is an important problem in patients with idiopathic myelofibrosis (IM). When other therapeutic measures are unsuccessful or not applicable, 40-50% favorable responses are obtained with androgen therapy. Oxymetholone is the drug usually employed, but good results have also been reported with danazol, although the experience is limited to a few patients. The aim of the present study was to evaluate the effect of danazol on the anemia of IM.
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Low-dose danazol after combined surgical and medical therapy reduces the incidence of pelvic pain in women with moderate and severe endometriosis
The most effective therapy for endometriosis is a matter for debate. The aim of the present randomized study was to evaluate the efficacy of low doses of danazol on recurrence of pelvic pain in patients with moderate or severe endometriosis, who had undergone laparoscopic surgery and 6 months of gonadotrophin-releasing hormone analogue (GnRHa) therapy.
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Latest News on Endometriosis 05 Jul 2008
endometriosis - Google News
endometriosis - Google News

"Better treatment" seen needed for endometriosis - Reuters

"Better treatment" seen needed for endometriosis
Reuters - Jul 4, 2008
By Megan Rauscher NEW YORK (Reuters Health) - Key-hole surgery to treat endometriosis is associated with good short-term outcomes but has a high reoperation ...

Reuters Health News Summary - San Diego Union Tribune

Reuters Health News Summary
San Diego Union Tribune, United States - 4 hours ago
NEW YORK (Reuters Health) ? Key-hole surgery to treat endometriosis is associated with good short-term outcomes but has a high reoperation rate in the long ...
Get Healthy: Your Middle-Aged Heart Will Thank You U.S. News & World Report
Heart failure outcomes worse in diabetics: study Reuters India
all 14 news articles

'Children - it's now or never' - The Island (subscription)

The Island (subscription)

'Children - it's now or never'
The Island (subscription), Sri Lanka - 7 hours ago
I have fibroids - and endometriosis, and polyps on my ovaries: my reproductive organs are the gynaecological equivalent of Basra. Thankfully, I've not been ...

World-first menstrual checklist for teens - August Margaret River Mail

World-first menstrual checklist for teens
August Margaret River Mail, Australia - Jul 4, 2008
Melissa Parker, of the Canberra Endometriosis Clinic, says work is under way on a "self-screening tool" - a checklist - that will soon be tested among ...

Repros Therapeutics Inc. Initiates a Comparative Phase 2b Study of ... - FOXBusiness

Repros Therapeutics Inc. Initiates a Comparative Phase 2b Study of ...
FOXBusiness - Jun 30, 2008
The data base to review the initial interim data for our current Phase 2 clinical study with Proellex for the treatment of endometriosis is scheduled to be ...

Pregnant Man Has Baby Girl - Blogger News Network

ITV.com

Pregnant Man Has Baby Girl
Blogger News Network - Jul 3, 2008
Nancy could not have a baby because of a hysterectomy after being diagnosed with endometriosis, but she already has two grown children. ...
Report: 'The Pregnant Man' Gives Birth People Magazine
Dani Garavelli: Labours of love Scotland on Sunday
Q&A: The 'pregnant man' guardian.co.uk
CTV.ca - TopNews
all 427 news articles

Endometriosis sufferer single handedly organises the UK's first ... - PR-Inside.com (Pressemitteilung)

Endometriosis sufferer single handedly organises the UK's first ...
PR-Inside.com (Pressemitteilung), Austria - Jun 23, 2008
Britain's first ever fund-raising event for the charity Endometriosis UK will take place in Halifax next month. The Butterfly Benefit is the brainchild of ...

Aromatase Inhibitors May Relieve Endometriosis-Associated Pain: Review - Medscape (subscription)

Aromatase Inhibitors May Relieve Endometriosis-Associated Pain: Review
Medscape (subscription) - Jun 20, 2008
Describe the evidence supporting the use of aromatase inhibitors for endometriosis. Identify limitations of studies on the use of aromatase inhibitors for ...

Lexington gynecologist's case goes to the jury - Kentucky.com

Lexington gynecologist's case goes to the jury
Kentucky.com, KY - Jul 1, 2008
An oophorectomy is considered a last-resort treatment for endometriosis, a disease characterized by tissue growth outside the uterus. ...

Neurocrine completes treatment phase for endometriosis study - Trading Markets (press release)

Neurocrine completes treatment phase for endometriosis study
Trading Markets (press release), CA - Jun 18, 2008
In addition, efficacy assessments of endometriosis symptoms using the composite pelvic sign and symptoms score and visual analog scale are secondary ...




 

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Categorization derived from National Library of Medicine.
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