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   Drugs and Chemicals /  D   Dalteparin (Fragmin, Tedelparin)

A low molecular weight fragment of heparin, prepared by nitrous acid depolymerization of porcine mucosal heparin. The mean molecular weight is 4000-6000 daltons. It is used therapeutically as an antithrombotic agent.


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Thrombosis
Formation and development of a thrombus or blood clot in the blood vessel.
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 Pharmacologic Action
  • Fibrinolytic Agent
    Fibrinolysin or agents that convert plasminogen to fibrinolysin.
  • Anticoagulant
    Agents that prevent blood clotting. Naturally occurring agents in the blood are included only when they are used as drugs.



Free Full Text 03 Jul 2008
Warfarin versus low-molecular-weight heparin therapy in cancer patients
Several LMWHs (low-molecular-weight heparins) have demonstrated superior efficacy to warfarin in the secondary prevention of VTE. In particular, the LMWH, dalteparin (Fragmin; Pfizer; New York, NY), has recently been shown to have superior efficacy to warfarin in a large trial of patients with cancer and VTE without increasing the risk of bleeding.
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Fondaparinux or enoxaparin for the initial treatment of symptomatic deep venous thrombosis: a randomized trial
The current standard initial therapies for deep venous thrombosis are low-molecular-weight heparin and unfractionated heparin. In a dose-ranging study of patients with symptomatic deep venous thrombosis, fondaparinux had efficacy and a safety profile similar to those of low-molecular-weight heparin (dalteparin).
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Leg compression and ambulation is better than bed rest for the treatment of acute deep venous thrombosis
Treatment of acute deep venous thrombosis (DVT) with low-molecular-weight heparin and vitamin K-antagonists reduces the risk of thrombus progression and pulmonary embolism but has no immediate effect on signs and symptoms. We addressed the question whether adding compression and walking would lead to a more rapid clinical improvement than bed rest.
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Effect of dalteparin on healing of chronic foot ulcers in diabetic patients with peripheral arterial occlusive disease: a prospective, randomized, double-blind, placebo-controlled study
Chronic foot ulcers are a common, severe, and expensive complication threatening life and limb in patients with diabetes. The aim of the present study was to investigate the effect of dalteparin on ulcer outcome in patients with diabetes, peripheral arterial occlusive disease, and chronic foot ulcers.
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Book Reviews 03 Jul 2008

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Categorization derived from National Library of Medicine.
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