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An indolic serotonin 5-HT (1B/1D)receptor agonist for the acute treatment of migraine,
acts as potent inhibitor of neurogenic inflammation.
(3-[2-(dimethylamino)ethyl]-5-(pyrrolidin-1-ylsulfonylmethyl )-1H-indo le)
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References:
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Pharmacologic Action
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Serotonin Agonist
(Agents that have an affinity for serotonin receptors and are able to mimic the effects of serotonin by stimulating
the physiologic activity at the cell receptors.
These compounds are used as antidepressants, anxiolytics, and in the treatment of migraine.)
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Migraine
A subtype of vascular headaches characterized by periodic unilateral pulsatile headaches
which begin in childhood, adolescence, or early adult life and recur with diminishing
frequency during advancing years.
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Classic Migraine
A condition characterized by throbbing headaches which are preceded or accompanied by
reversible symptoms that reflect cortical or brain stem dysfunction. The most common type
of aura consists of a positive visual phenomenon, usually in the form of a scintillating
scotoma. An aura may also take the form of other focal neurologic symptoms or signs,
including loss of sensation or weakness in an extremity. In general, the aura precedes
the headache by less than 60 minutes,
develops over 4 minutes or longer, and has a duration of less than one hour.
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Common Migraine
Recurrent vascular headaches not preceded or accompanied by an aura. In general,
episodes have the following characteristics: duration of 4-72 hours, moderate
to severe intensity, throbbing quality, unilateral cranial distribution, and
aggravation by physical activity.
Nausea, emesis, photophobia, or phonophobia accompanies the pain.
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