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  Home   Carbamazepine (Epitol, Finlepsin, Neurotol, Tegretol)

An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but some of its actions resemble those of Phenytoin; although there is little chemical resemblance between the two compounds, their three-dimensional structure is similar.


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   Related Disorders   

Seizures
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as Epilepsy or "seizure disorder."
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Epilepsy
A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon:
> clinical features of the seizure episodes (e.g., motor seizure),
> etiology (e.g., post-traumatic),
> anatomic site of seizure origin (e.g., frontal lobe seizure),
> tendency to spread to other structures in the brain, and
> temporal patterns (e.g., nocturnal epilepsy).
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 Pharmacologic Action
  • Anticonvulsant
    Drugs used to prevent seizures or reduce their severity.
  • Antimanic Agent
    Agents that are used to treat bipolar disorders or mania associated with other affective disorders.

  • Non Narcotic Analgesic
    Drugs that have principally analgesic, antipyretic, and anti-inflammatory actions. They do not bind to opioid receptors and are not classified under the Controlled Substances Act.





Free Full Text 07 Aug 2008
Antibody deficiency associated with carbamazepine
A 45 year old woman was referred to our immunology department with antibody deficiency and an eight month history of recurrent upper respiratory tract infections that required antibiotic therapy. Four years previously she was diagnosed as having epilepsy and was treated with carbamazepine.
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Comparative Cognitive Effects of Carbamazepine and Gabapentin in Healthy Senior Adults
This study compared the cognitive effects of carbamazepine (CBZ) and gabapentin (GBP) in healthy senior adults by using a randomized, double-blind crossover design.
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Do New Antiepileptic Drugs Interact with Oral Contraceptives?
Women with epilepsy or with nonepileptic conditions, which have responded therapeutically to AEDs (e.g., neuropathic pain, bipolar disorder, migraine prophylaxis), are frequently treated with oral contraceptive medications containing norethindrone and ethinyl estradiol, both of which are metabolized in the P450 (CYP)3A system.
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Anticonvulsant hypersensitivity syndrome. In vitro assessment of risk
Arene oxide metabolites of aromatic anticonvulsants (phenytoin, phenobarbital, and carbamazepine) may be involved in the pathogenesis of hypersensitivity reactions.
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Anticonvulsants and antipsychotics in the treatment of bipolar disorder
Bipolar disorder is a complex medical condition, and up to the date there is no single treatment with proven efficacy in the control of all aspects of the illness. The available literature on the use of anticonvulsants (valproate, carbamazepine, oxcarbazepine, lamotrigine, gabapentin, topiramate, clonazepam) and atypical antipsychotics (clozapine, risperidone, olanzapine, quetiapine, ziprasidone, and aripiprazole) for acute and prophylactic treatment of bipolar disorder was reviewed.
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Book Reviews 07 Aug 2008

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Categorization derived from National Library of Medicine.
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