Web Dentalarticles.com
   Drugs and Chemicals /  B   Busulfan (Busulfex, Myleran)

An alkylating agent having a selective immunosuppressive effect on bone marrow. It has been used in the palliative treatment of chronic myeloid leukemia, but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.


References:
   Related Disorders   

Myeloid Leukemia
Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors in the bone marrow and other sites.
[ Articles]
Chronic Myeloid Leukemia
>> Blast Crisis
Rapid increase in the proportion of blast cells in the blood and bone marrow.
[ Articles]
>> Chronic Monocytic Leukemia
[ Articles]
>> Aggressive-Phase Myeloid Leukemia
[ Articles]
>> Chronic-Phase Myeloid Leukemia
[ Articles]
>> Chronic Myelomonocytic Leukemia
[ Articles]
>> Chronic Neutrophilic Leukemia
[ Articles]



 Pharmacologic Action
  • Alkylating Agent
    Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.
  • Immunosuppressive Agent
    Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of suppressor T-cell populations or by inhibiting the activation of helper cells. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of interleukins and other cytokines are emerging.
  • Alkylating Antineoplastic Agent
    A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood.



Leukemia News 05 Jul 2008
Yahoo! News Search Results for leukemia
Yahoo! News Search Results for leukemia

Lakewood event helps to fight leukemia (Northwest Herald)
LAKEWOOD ? When Andy Hanson was diagnosed with leukemia in 1994 at the age of 22, he received an outpouring of support.
Lakewood resident leads local Leukemia & Lymphoma Society's Team in Training (Dallas Morning News)
CHRIS GRESBACK Chris Gresback is a freelance writer in Lakewood. Last weekend, while driving past the tennis courts on Tokalon and West Shore Drives, I came across a troop of walkers/hikers.
'Connection' producer Lieber dead at 71 (Moldova.org)
Eric Lieber, executive producer for the popular TV series Love Connection, has died in Los Angeles at the age of 71, his wife says.Peggy Lieber confirmed the TV producer died of leukemia at Cedars-Sinai Medical Center, ending a successful television career, the Los Angeles Times reported Saturday.In addition to serving as executive producer for Connection, which ran from 1983 to 1995, Lieber ...
Fire department honors fallen firefighters (The Oxford Press)
When Fairfield Twp. Fire Department commissions a new fire engine into service next week, the memory of fallen firefighters will make every run. ? Chris Wisner, a Fairfield Twp. firefighter who died Jan. 17 following a three-year battle against acute myelogenous leukemia.
Jackson Christian's John Pryor turns his battle with leukemia into inspiration (The Jackson Citizen Patriot)
When John Pryor was a junior at Jackson Christian High School, he turned a class assignment into a life-saving and an eye-opening experience. And when it comes to life-saving experiences, Pryor has more than his share of first-hand knowledge.
Friend takes Ron's battle to Alaska (Daily Journal)
VINELAND -- Dora Messick entered the Midnight Sun Marathon in Alaska with the goal of raising about $5,000 to benefit the Leukemia & Lymphoma Society.
Medical briefs (St. Charles Journal)
Light the Night Walk in St. Peters park The Leukemia and Lymphoma Society's Gateway Chapter is recruiting teams and sponsors for the nationwide Light the Night Walk on Sept. 12 at City Centre Park, adjacent to the St. Peters Rec-Plex, and Forest Park in St. Louis.
Prolific fiddler Oliver Schroer dies of cancer (CTV.ca)
Legendary Toronto fiddler Oliver Schroer died of leukemia this week, leaving fans and students of his unique style mourning the loss of an icon.
Treating Chronic Lymphocytic Leukemia (US News & World Report)
? Presently, there is no cure for CLL/SLL. The overall goal of leukemia treatment is to bring about a remission. During remission, the signs and symptoms of the cancer disappear; however, the cancer may still be in the body.
Chronic Lymphocytic Leukemia Symptoms (US News & World Report)
In its early phases, chronic lymphocytic leukemia/small lymphocytic lymphoma doesn't usually reveal itself with obvious signs. Most people who are diagnosed with CLL/SLL have no symptoms; the disease is found incidentally during a routine blood test.

 

Book Reviews 05 Jul 2008

List Price:
Amazon.com Price:
Publisher:
Availability:
Amazon.com sales rank:
Average customer rating:
Buy Now

Warning: Invalid argument supplied for foreach() in /usr/www/users/dentalar/drugs/77.php on line 359



Categorization derived from National Library of Medicine.
Disclaimer