An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the
treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens
(NTP 85-002, 1985), this substance has been listed as a known carcinogen.
Antimetabolite
Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere with normal metabolic pathways.
Antirheumatic Agent
Drugs that are used to treat rheumatoid arthritis.
Immunosuppressive Agent
Agents that suppress immune function by one of several mechanisms of action. Classical
cytotoxic immunosuppressants act by inhibiting DNA synthesis.
Others may act through activation of suppressor T-cell populations or by inhibiting the
activation of helper cells. While immunosuppression has been brought about in the past
primarily to prevent rejection of transplanted organs, new applications involving
mediation of the effects of interleukins and other cytokines are emerging.
Antineoplastic Antimetabolite Antimetabolites that are useful in cancer chemotherapy.
