A pyrimidine analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent.
Leukemia
A progressive, malignant disease of the blood-forming organs, characterized by distorted
proliferation and development of leukocytes and their precursors in the blood and bone marrow.
It is classified according to degree of cell differentiation as acute or chronic,
and according to predominant type of cell involved as myelogenous or lymphocytic.
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Pharmacologic Action
Antineoplastic Antimetabolite
Antimetabolites that are useful in cancer chemotherapy.
Enzyme Inhibitor
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
