Drugs and Chemicals /
PPromethazine
(Phenergan, Prothazin, Pyrethia, Remsed, Rumergan)
A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
Motion Sickness
Disorder caused by motion, as sea sickness, train sickness, car sickness, air sickness, or space motion sickness. It may include nausea, vomiting and dizziness.
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Pharmacologic Action
Anti Allergic Agent (Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells.)
Antipruritic (Agents, usually topical, that relieve itching (pruritus).)
Histamine H1 Antagonist (Drugs that selectively bind to but do not activate histamine H1 receptors,
thereby blocking the actions of endogenous histamine. Included here are the classical
antihistaminics that antagonize or prevent the action of histamine mainly in immediate
hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles,
and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic
dermatitis and to induce somnolence.
The effects of blocking central nervous system H1 receptors are not as well understood.)
