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   Drugs and Chemicals /  A   Aspirin (Polopiryna, Solprin, Solupsan, Zorprin )

The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis.


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Thrombosis
Formation and development of a thrombus or blood clot in the blood vessel.
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 Pharmacologic Action
  • Non-Steroidal Anti-Inflammatory Agent
    (Anti-inflammatory agents that are not steroids. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They are used primarily in the treatment of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. Certain NSAIDs also may inhibit lipoxygenase enzymes or phospholipase C or may modulate T-cell function.)
  • Cyclooxygenase Inhibitor
    (Compounds or agents that combine with cyclooxygenase and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.)
  • Fibrinolytic Agent
    (Fibrinolysin or agents that convert plasminogen to fibrinolysin.)
  • Platelet Aggregation Inhibitor
    (Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.)
Latest News on Aspirin 17 May 2008
aspirin - Google News
aspirin - Google News

Aspirin at Bedtime Lowers Blood Pressure - Washington Post

MSN India

Aspirin at Bedtime Lowers Blood Pressure
Washington Post, United States - May 14, 2008
By Ed Edelson WEDNESDAY, May 14 (HealthDay News) -- A daily aspirin can control prehypertension, but only if it is taken at bedtime, a Spanish study shows. ...
Sleeping On It Really Can Relieve the Pressure Newswise (press release)
Music eases blood pressure, say researchers Hindu
Relax To Music, Ease Blood Pressure CBS News
U.S. News & World Report - Washington Post
all 53 news articles

ASH: Bedtime Aspirin Lowers Blood Pressure - MedPage Today

ASH: Bedtime Aspirin Lowers Blood Pressure
MedPage Today, NJ - May 16, 2008
By Peggy Peck, Executive Editor, MedPage Today NEW ORLEANS, May 16 -- A low-dose aspirin taken at bedtime was associated with significant 24-hour reductions ...

Regular Aspirin Intake Cuts Breast Cancer Risk - Medi News Direct

dBTechno

Regular Aspirin Intake Cuts Breast Cancer Risk
Medi News Direct, India - May 16, 2008
Daily intake of aspirin reduces the risk of developing estrogen receptor (ER) - positive breast cancer, according to a study published in the recent issue ...
Omega-3 linked to lower colorectal cancer risk NutraIngredients.com
all 560 news articles

Cholesterol-lowering drugs may protect against cancer - The Post

Cholesterol-lowering drugs may protect against cancer
The Post, Pakistan - 7 hours ago
We need to look at this drug, it might be the next wonder drug after aspirin." In fact, the Alzheimer's Association notes that some studies have found a ...

Daily Aspirin May Reduce Breast Cancer Risk - Atlanta Journal Constitution

Daily Aspirin May Reduce Breast Cancer Risk
Atlanta Journal Constitution,  USA - May 1, 2008
THURSDAY, May 1 (HealthDay News) -- Women who take an aspirin each day may reduce their risk of developing the most common type of breast cancer by 16 ...
'An aspirin a day can keep breast cancer away' Telegraph.co.uk
Aspirin 'may help cut cancer risk' The Press Association
Aspirin seen cutting risk of type of breast cancer Reuters
guardian.co.uk - CTV.ca
all 108 news articles

Mini aspirin taken at night cuts risk of heart attacks, say ... - Daily Mail

Daily Mail

Mini aspirin taken at night cuts risk of heart attacks, say ...
Daily Mail, UK - May 13, 2008
A small dose of aspirin may cut the risk of heart attack or stroke in those with rising blood pressure - but only if it is taken at night. ...
New Data Shows 45 Percent of Patients With Stage 1 Hypertension ... Earthtimes (press release)
all 15 news articles

Overdosed to death - Winnipeg Sun

Overdosed to death
Winnipeg Sun, Canada - 20 hours ago
She wouldn't take Aspirin for a headache," he said. "That's why this is quite a shock. I still wait for her, hoping that it's a mistake, but I know she's ...

Combination therapy falls short of noninferiority vs clopidogrel - TheHeart.Org

Combination therapy falls short of noninferiority vs clopidogrel
TheHeart.Org, NY - May 16, 2008
Nice, France - Results of the largest secondary stroke-prevention trial comparing the combination of aspirin and extended-release dipyridamole ...

No Functional, Cognitive Benefits Achieved With PROFESS Regimens ... - DG News

No Functional, Cognitive Benefits Achieved With PROFESS Regimens ...
DG News - 19 hours ago
"There was no significant difference in the Modified Rankin Scale at 3 months post-stroke between extended-release dipyridamole plus aspirin versus ...

PRoFESSŪ results announced at XVII European Stroke Conference - WebWire (press release)

PRoFESSŪ results announced at XVII European Stroke Conference
WebWire (press release), GA - May 16, 2008
Across an average observation time of 2.5 years the rates of first recurrent stroke were similar for the two treatments (9.0% ER-DP plus aspirin, ...



 

Book Reviews 17 May 2008

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Categorization derived from National Library of Medicine.
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