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A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues.
It is an inhibitor of proteolytic enzymes including chymotrypsin, kallikrein, plasmin, and
trypsin. It is used in the treatment of hemorrhage associated with raised plasma
concentrations of plasmin. It is also used to reduce blood loss and transfusion
requirements in patients at high risk of major blood
loss during and following open heart surgery with extracorporeal circulation.
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References:
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Coronary Artery Bypass Surgery
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of
saphenous vein, internal mammary artery, or other substitute between the aorta
and the obstructed coronary artery distal to the obstructive lesion.
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Articles]
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Pharmacologic Action
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Hemostatic
(Agents acting to arrest the flow of blood. Absorbable hemostatics arrest bleeding
either by the formation of an artificial clot or by providing a mechanical matrix that
facilitates clotting when applied directly to the bleeding surface. These agents function
more at the capillary level and are not effective at stemming
arterial or venous bleeding under any significant intravascular pressure.)
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Antiviral Agent
(Agents used in the prophylaxis or therapy of virus diseases. Some of the ways they
may act include preventing viral replication by inhibiting viral DNA polymerase; binding
to specific cell-surface receptors and inhibiting viral penetration or uncoating;
inhibiting viral protein synthesis; or blocking late stages of virus assembly.)
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Serine Proteinase Inhibitor
(Exogenous or endogenous compounds which inhibit serine endopeptidases.)
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Trypsin Inhibitor
(Serine proteinase inhibitors which inhibit trypsin. They may be endogenous or exogenous compounds.)
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