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An antianginal and antiarrhythmic drug. It increases the duration of ventricular and
atrial muscle action by inhibiting Na,K-activated myocardial adenosine triphosphatase.
There is a resulting decrease in heart rate and in vascular resistance.
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References:
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The symptom of paroxysmal pain consequent to myocardial ischemia usually of distinctive
character, location and radiation.
It is thought to be provoked by a transient stressful situation during which the oxygen
requirements of the myocardium exceed that supplied by the coronary circulation.
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Articles]
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Pharmacologic Action
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Anti-Arrhythmia Agent
(Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.)
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Vasodilator Agent
(Drugs used to cause dilation of the blood vessels.)
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Enzyme Inhibitor
(Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.)
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