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An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking
the production of adrenal steroids. It also blocks the conversion of androgens to estrogens.
Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer.
It was formerly used for its weak anticonvulsant properties.
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References:
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Pharmacologic Action
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Aromatase Inhibitor
(Compounds that inhibit aromatase in order to reduce production of estrogenic steroid hormones.)
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Hormonal Antineoplastic Agent
(Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias.)
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Adrenergic Agent
(Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.)
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