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A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal
epithelial cells. This inhibition creates a negative potential in the luminal membranes
of principal cells, located in the distal convoluted tubule and collecting duct. Negative
potential reduces secretion of potassium and hydrogen ions.
Amiloride is used in conjunction with diuretics to spare potassium loss
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References:
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Pharmacologic Action
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Diuretic
(Agents that promote the excretion of urine through their effects on kidney function.)
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Hypokalemia
Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders.
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Edema
Excessive amount of watery fluid accumulated in the intercellular spaces, most commonly present in subcutaneous tissue.
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