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   Drugs and Chemicals /  E   Echinacea (Purple Conflower, Black Susans, Indian Head)

A genus of perennial herbs used topically and internally. It contains echinacoside, glycosides; inulin; isobutyl amides, resin, and sesquiterpenes.




  • Glycosides
    Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed.
  • Inulin
    A starch found in the tubers and roots of many plants. Since it is hydrolyzable to fructose, it is classified as a fructosan. It has been used in physiologic investigation for determination of the rate of glomerular function.

Articles


Efficacy and safety of echinacea in treating upper respiratory tract infections in children:
Echinacea is a widely used herbal remedy for treatment of upper respiratory tract infections (URIs). However, there are few data on the efficacy and safety of echinacea in treating URIs in children. Echinacea purpurea, as dosed in this study, was not effective in treating URI symptoms in patients 2 to 11 years old, and its use was associated with an increased risk of rash
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Echinacea and truth in labeling
Echinacea sales represent 10% of the dietary supplement market in the United States, but there is no guarantee as to the content, quality, variability, or contamination in Echinacea preparations. Echinacea from retail stores often does not contain the labeled species. A claim of "standardization" does not mean the preparation is accurately labeled, nor does it indicate less variability in concentration of constituents of the herb.
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The National Toxicology Program : Executive Summary Echinacea
Echinacea is presented to the CSWG as part of a review of botanicals being used as dietary supplements in the United States. Alternative herbal medicines are projected to be a $5 billion market by the turn of the century. Echinacea is an extremely popular herbal supplement; sales are nearly $300 million a year according to the last figures available.
Sweeping deregulation of botanicals now permits echinacea to be sold to the public without proof of safety or efficacy if the merchandiser notes on the label that the product is not intended to diagnose, treat, cure, or prevent any disease. The literature on echinacea clearly showed that it is being used for the treatment of viral and bacterial infections although virtually no information on safety was found.
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What's on a dietary supplement's label may not be what's in the bottle
Echinacea is a commercial success. The dietary supplement—made from the flowers, stems, and leaves of the purple coneflower—has become a popular and lucrative over-the-counter cold remedy. It's also one of the few nutraceuticals—natural products with medicinal reputations—that have substantial scientific evidence to support its purported functions: Various studies suggest that echinacea supplements can boost immunity or shorten the duration of colds.
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Dietary Supplement Use in Children: Concerns of Efficacy and Safety
In a national online survey, 41 percent of 520 adolescents reported that they had used herbal or green tea, zinc, echinacea or echinacea/goldenseal, ginseng, ginger, ginkgo biloba, soy supplements, omega 3 fatty acids or fish oil, creatine, weight loss supplements, St. John's wort, valerian, ephedra, or feverfew. Children with chronic conditions such as cystic fibrosis, attention deficit disorder, asthma, atopic dermatitis, allergic rhinitis, cancer, inflammatory bowel disease, and rheumatoid arthritis have higher dietary supplement use than children without these conditions.
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Use of dietary supplements in cancer patients
In 1996, total sales in dietary supplements were $9.8 billion, and it is estimated that 35–50% of the general public currently use dietary supplements (Nutrition Business Journal 1999 ). Sales are continuing to grow. In 1998, consumers were spending $13.9 billion on supplements, which was 51% of the total sales in the United States nutrition industry. The top five single botanicals sold in the United States in 1997 were echinacea (7%), ginseng (8%), ginkgo (7%), St. John’s wort (6%) and garlic (6%) (Nutrition Business Journal 1997 and 1998 ). Multiherbal products comprised 27% of the total sales.
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Book Reviews 08 Aug 2008

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Categorization derived from National Library of Medicine.
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