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Drugs and Chemicals /
Z
Zileuton
(Zyflo) |
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Pharmacologic Action
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| Free Full Text | 03 Jul 2008 |
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Zileuton: the first 5-lipoxygenase inhibitor for the treatment of asthma
Zileuton represents the first drug of a new treatment category for asthma, the 5-lipoxygenase inhibitors. Some people with asthma may receive considerable benefit, but as it is an entirely new drug entity, zileuton's final place in the hierarchy of asthma medications remains to be determined. Read more Anti-inflammatory effects of Zileuton in a subpopulation of allergic asthmatics For the first time in 20 yr, a new class of drugs has been developed to treat asthma. These novel compounds act by either inhibiting the synthesis of leukotrienes or by blocking their biologic activity. Thus, leukotriene inhibition may offer a more specific mechanism to block inflammatory responses in asthma than currently available therapeutic interventions. Read more Safety and clinical efficacy of zileuton in patients with chronic asthma Zileuton, a leukotriene pathway inhibitor used to treat asthma, improves lung function, relieves symptoms, and is well tolerated. The purpose of this 12-month, parallel-group, open-label study was to assess the efficacy of zileuton and evaluate liver function in patients treated with this drug (approximately 2% of patients treated with zileuton in controlled trials had reversible liver enzyme elevations). Read more Management of asthma in children The prevalence of asthma in children has increased 160 percent since 1980, and the disease currently affects nearly 5 million children in the United States. The National Asthma Education and Prevention Program provides guidelines for improved asthma care. The goals of this program are to limit the frequency, severity and costliness of asthma exacerbations through extensive education of physicians, children and caregivers Read more New strategies in the medical management of asthma Asthma, a common chronic inflammatory disease of the airways, may be classified as mild intermittent or mild, moderate, or severe persistent. Patients with persistent asthma require medications that provide long-term control of their disease and medications that provide quick relief of symptoms. Medications for long-term control of asthma include inhaled corticosteroids, cromolyn, nedocromil, leukotriene modifiers and long-acting bronchodilators. Inhaled corticosteroids remain the most effective anti-inflammatory medications in the treatment of asthma. Read more Asthma therapy during pregnancy Numerous pregnant women suffer from asthma and the use of asthma medications during pregnancy may be a necessity. Although some information is known about the effects of asthma medications during pregnancy, there is still a significant amount of information to learn and particular attention is required when prescribing drugs to these patients. Read more The role of leukotriene modifiers in the treatment of asthma The recent U.S. Food and Drug Administration (FDA) approval of a leukotriene-receptor antagonist, zafirlukast (Accolate), and a leukotriene synthesis inhibitor, zileuton (Zyflo), provides the first mediator-specific therapy for asthma. This review will consider the biochemistry of the leukotrienes, their biologic role in asthma, and the therapeutic potential of drugs that alter the production or action of leukotrienes, as well as provide guidelines for the use of leukotriene modifiers in patients with asthma. Read more |
| Book Reviews | 03 Jul 2008 |
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