Ubiquinone derivative;
(A lipid-soluble benzoquinone which is involved in electron transport in mitochondrial preparations. The compound occurs in the majority of aerobic organisms, from bacteria to higher plants and animals.)
Related Disorders
Oxidative Stress
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading
to potential damage. Indicators of oxidative stress include
damaged DNA bases, protein oxidation products, and lipid peroxidation products.
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Articles]
Articles
Coenzyme Q10 and Cardiovascular Disease: A Review
This article provides a comprehensive review of 30 years of research on the use of coenzyme
Q10 in prevention and treatment of cardiovascular disease. This endogenous antioxidant has
potential for use in prevention and treatment of cardiovascular disease,
particularly hypertension, hyperlipidemia, coronary artery disease, and heart failure.
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Topical vitamins, minerals and botanical ingredients as modulators of environmental and chronological skin damage
Ageing skin is characterized by fine lines, wrinkles, lentigines, dyspigmentation
and increased coarseness. Topical preparations alleged to combat these changes abound
in the over-the-counter market. Some of the most popular
ingredients used in these products are vitamins, minerals and botanical extracts
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Coenzyme Q10, a cutaneous antioxidant and energizer
The processes of aging and photoaging are associated with an increase in cellular oxidation.
This may be in part due to a decline in the levels of the endogenous cellular antioxidant
coenzyme Q10 (ubiquinone, CoQ10). Therefore, we have investigated whether
topical application of CoQ10 has the beneficial effect of preventing photoaging.
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Coenzyme Q10--its importance, properties and use in nutrition and cosmetics
Coenzyme Q10, or ubiquinone, is a nutrient--a vitamin-like substance which plays a crucial
role in the generation of cellular energy an in free radical scavenging in the human body.
After the age of 35 to 40, the organism begins
to lose its ability to synthesize Co Q10 from food and its deficiency develops.
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Modulation of oxidative stresses in human aging skin
Oxidative stress (UV irradiation, free radicals) plays a significant role in aging.
Coenzyme Q10 (CoQ10) and exogenously applied antioxidants
can significantly reduce the formation of oxidative stress with increasing age.
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The role of antioxidants in exercise and disease prevention
Excess free-radical formation has been hypothesized to contribute to cancer, atherosclerosis,
aging, and exercise-associated muscle damage. Antioxidant supplements such as vitamin C,
vitamin E, and beta-carotene have been touted as
beneficial for enhancing exercise performance and for preventing certain diseases.
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Coenzyme Q10 and adverse effects of statins
Several studies have reported a significant reduction in serum coenzyme Q10 in patients
taking statins. Such concern was also expressed by the International College of Cardiology
at their meeting in April 2002; it was proposed that coenzyme Q10 should
be considered in the prevention as well as the treatment of statin intoxication.
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Pharmacologic Action
Antioxidant
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
