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   Drugs and Chemicals /  V   Vitamin E (Aquasol E, Softgels, Vitec)

A generic descriptor for all Tocopherols and Tocotrienols that exhibit Alpha-Tocopherol activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of isoprenoid.


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Vitamin E Deficiency
A nutritional condition produced by a deficiency of Vitamin E in the diet, characterized by posterior column and spinocerebellar tract abnormalities, areflexia, ophthalmoplegia, and disturbances of gait, proprioception, and vibration. In premature infants vitamin E deficiency is associated with hemolytic anemia, thrombocytosis, edema, intraventricular hemorrhage, and increasing risk of retrolental fibroplasia and bronchopulmonary dysplasia. An apparent inborn error of vitamin E metabolism, named familial isolated vitamin E deficiency, has recently been identified.
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 Pharmacologic Action
  • Antioxidant
    Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.






Free Full Text 05 Jul 2008
High Vitamin E Intake among U.S. Adults
Vitamin E is in many foods, including nuts, oils, and vegetables. People in western countries usually consume small amounts of this vitamin in their diets. People also can buy multivitamins and supplements that contain vitamin E. Each multivitamin often contains about 30 international units (IU) of vitamin E. Many experts recommend this daily amount for adults. Supplements often contain much larger amounts, such as 200, 400, or 1,000 IU.
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Vitamin E in plant seeds could halt prostate, lung cancer, says Purdue scientist
The form of vitamin E found in many plant seeds – but not in most manufactured nutritional supplements – might halt the growth of prostate and lung cancer cells, according to a Purdue University study.
A team led by Qing Jiang (pronounced "ching zhang") has found that gamma-tocopherol, which occurs naturally in walnuts, pecans, sesame seeds, and in corn and sesame oils, inhibits the proliferation of lab-cultured human prostate and lung cancer cells. The vitamin's presence interrupts the synthesis of certain fatty molecules called sphingolipids, important components of cell membranes. However, the gamma-tocopherol leaves healthy human prostate cells unaffected, which could give it value as an anticancer agent.
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Do vitamins C and E protect against the development of carotid stenosis and cardiovascular disease?
Some observational and randomized, clinical interventional studies have indicated that the antioxidative vitamins C (ascorbic acid) and E (alpha-tocopherol) can reduce intima-media thickness of the carotid arteries. It is, however, not clarified whether these vitamins may have a preventive effect against cardiovascular events.
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Advances in diabetes for the millennium: vitamins and oxidant stress in diabetes and its complications
Hyperinduced oxidant stress may have a role in the pathogenesis of diabetes and its micro- and macrovascular complications. Attaining euglycemia and the use of antioxidant vitamins could reduce oxidant stress and complications. In general, evidence does not support the use of supplements, and supplements are not recommended unless patients are deficient. Use of vitamins in excess may have adverse effects.
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Study finds huge variability in Vitamin E absorption
Scientists tested the results of four different types of breakfasts: a pill of 400 I.U. of vitamin E with skim milk; a serving of a wheat breakfast cereal fortified with 30 I.U. of vitamin E; a serving of wheat breakfast cereal fortified with 400 I.U. of vitamin E; and a serving of wheat breakfast cereal with a pill of 400 I.U. vitamin E taken separately.
The pill of 400 I.U. vitamin E taken with just a glass of milk, in theory, should have provided more than 13 times the RDA of this nutrient. But, in fact, it raised the level of new vitamin E in the blood by only 3 percent. By comparison, the cereal fortified with 30 I.U. vitamin E raised the blood plasma level of new vitamin E five times higher than that, and the cereal fortified with 400 I.U. raised the new blood plasma level 30 times higher.
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Nutritional support for wound healing
Vitamin A is required for epithelial and bone formation, cellular differentiation, and immune function. Vitamin C is necessary for collagen formation, proper immune function, and as a tissue antioxidant. Vitamin E is the major lipid-soluble antioxidant in the skin; however, the effect of vitamin E on surgical wounds is inconclusive.
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Book Reviews 05 Jul 2008

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Categorization derived from National Library of Medicine.
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