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   Drugs and Chemicals /  O   Ofloxacin (Tarivid, Floxin, Ocuflox)

A synthetic fluoroquinolone (A group of quinolones with at least one fluorine atom and a piperazinyl group) antibacterial agent that inhibits the supercoiling activity of bacterial Dna gyrase, halting Dna replication.


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Urinary Tract Infections
Infections affecting those structures of the body which participate in the secretion and elimination of urine, i.e., the kidney, the ureters, the urinary bladder, and the urethra.
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 Pharmacologic Action
  • Anti Infective Agent
    Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
  • Urinary Anti Infective Agent
    Substances capable of killing agents causing urinary tract infections or of preventing them from spreading.



Free Full Text 07 Oct 2008
Susceptibility patterns of enterococci causing infections
Enterococci are among the common organisms associated with hospital-acquired infections. We examined in vitro activities of different antibiotics to 103 enterococcal isolates. Minimal inhibitory concentrations (MICs) of penicillin G, ampicillin, gentamicin, ciprofloxacin, ofloxacin, levofloxacin, grepafloxacin, trovafloxacin and gemifloxacin were determined by broth microdilution testing method.
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Topical ciprofloxacin/dexamethasone otic suspension is superior to ofloxacin otic solution in the treatment of children with acute otitis media with otorrhea through tympanostomy tubes
Objective:
To determine the efficacy and safety of topical ciprofloxacin/dexamethasone otic suspension compared with ofloxacin otic solution in the treatment of acute otitis media with otorrhea through tympanostomy tubes (AOMT) in pediatric patients.
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Evaluation of ofloxacin penetration into the skin after a single oral dose assessed by cutaneous microdialysis
An antibacterial drug can exert its therapeutic action if it is present in target tissue at proper concentration. Cutaneous microdialysis is a relatively new technique, which allows to determine drug concentration in the skin. The aim of the study was to evaluate the ofloxacin concentrations in plasma and skin following a single oral dose of 0.4 g. Drug concentration in the skin was assessed by applying cutaneous microdialysis.
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Book Reviews 07 Oct 2008

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Categorization derived from National Library of Medicine.
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