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   Drugs and Chemicals /  N   Nalidixic Acid (Nalidixin, NegGram)

A synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial Dna Gyrase.


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Urinary Tract Infections
Infections affecting those structures of the body which participate in the secretion and elimination of urine, i.e., the kidney, the ureters, the urinary bladder, and the urethra.
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 Pharmacologic Action
  • Anti Infective Agent
    Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
  • Enzyme Inhibitor
    Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.



Free Full Text 05 Jul 2008
The quinolones: decades of development and use
The discovery of nalidixic acid in 1962, and its introduction for clinical use in 1967, marks the beginning of five decades of quinolone development and use. It was not until the discovery and licensing of the fluoroquinolones in the 1970s and 1980s that these drugs began to establish their place in the armamentarium of clinically useful antimicrobials.
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Changes in the antimicrobial susceptibility of Escherichia coli isolates from nosocomial versus community-acquired urinary tract infections
Penicillins were the least active antibiotic agents against the E. coli isolated (sensitivity 40.9%), followed by cotrimoxazole (66.4%), nalidixic acid (70.8%) and norfloxacin (76.1%).
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International Note - Antibiotics in the management of shigellosis
Nalidixic acid and ciprofloxacin both belong to a group of antimicrobials known as "quinolones", nalidixic acid being the first antimicrobial agent developed in this family of antibiotics. In a few clinical trials conducted in the 1970s and 1980s, nalidixic acid was shown to be clinically effective against Shigella.
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Aeromonas spp. and traveler's diarrhea: clinical features and antimicrobial resistance
Traveler's diarrhea is the most common health problem of international travelers. We determined the prevalence of Aeromonas spp. associated with traveler's diarrhea and analyzed the geographic distribution, clinical features, and antimicrobial susceptibility.
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Latest News on Urinary Tract Infections 05 Jul 2008
urinary tract infections - Google News
urinary tract infections - Google News

New drug to treat bacteria infections - New Vision

New drug to treat bacteria infections
New Vision, Uganda - Jul 1, 2008
These are acute pneumonia, chronic lower and upper respiratory tract infections and urinary tract infections lik e.coli. Cefodox, available in tablet and ...

Study: Silver-Coated Catheters Reduce Urinary Tract Infections - Nurse.com

Study: Silver-Coated Catheters Reduce Urinary Tract Infections
Nurse.com, VA - Jun 30, 2008
... been found to reduce the number of catheter-associated urinary tract infections (CAUTI) among patients in the hospital as compared to latex catheters. ...

Half of SIUT urological work for kidney stones - Daily Times

Half of SIUT urological work for kidney stones
Daily Times, Pakistan - 1 hour ago
... kidney stones because people are not drinking enough water, have low citrate levels and high oxiate levels in their urine and urinary tract infections. ...

Nipple Discharge Often Has No Significance - RedOrbit

Nipple Discharge Often Has No Significance
RedOrbit, TX - Jul 4, 2008
The subject of urinary tract infections is discussed at length in the booklet on that topic. Readers can obtain a copy by writing: Dr. Donohue - No. ...

Is Burning Love Causing Burning Below? - PR Web (press release)

PR Web (press release)

Is Burning Love Causing Burning Below?
PR Web (press release), WA - Jul 2, 2008
New Jersey (PRWEB) July 2, 2008 -- If you think sex and urinary tract infections (UTI) go together, you're not alone. A Harris Interactive survey conducted ...

Sexually transmitted disease, urinary tract infections may be bad ... - EurekAlert (press release)

Sexually transmitted disease, urinary tract infections may be bad ...
EurekAlert (press release), DC - Jun 20, 2008
SALT LAKE CITY -- Women who reported having both a sexually transmitted disease (STD) and urinary tract infection (UTI) just before or during early ...

Birth defect linked to dual infections - Salt Lake Tribune

Birth defect linked to dual infections
Salt Lake Tribune, United States - Jun 20, 2008
By Heather May As if having a sexually transmitted disease and a urinary tract infection weren't enough of a problem, researchers have found that together, ...

Urine and blood infection a fatal combination - Great Falls Tribune

Urine and blood infection a fatal combination
Great Falls Tribune, MT - Jul 1, 2008
By DAN GOLD ? For the Tribune ? July 1, 2008 Urinary tract infections are a common patient complaint in any primary care medical practice. ...

Screening for Asymptomatic Bacteriuria in Adults: Evidence for the ... - Annals of Internal Medicine

Screening for Asymptomatic Bacteriuria in Adults: Evidence for the ...
Annals of Internal Medicine - Jun 30, 2008
Urinary tract infections are usually easy to treat with antibiotics, but sometimes serious complications can occur, including kidney damage or spread of the ...
USPSTF Reissues Recommendations for Asymptomatic Bacteriuria ... Medscape (subscription)
Screening for Asymptomatic Bacteriuria in Adults: Evidence for the ... Annals of Internal Medicine
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Doctor's Advice: Bladder blues - Jamaica Gleaner

Doctor's Advice: Bladder blues
Jamaica Gleaner, Jamaica - Jun 20, 2008
A Urinary tract infections (UTIs) are extremely common in young women from the time they first start having sex. They are mainly caused from germs getting ...




 

Book Reviews 05 Jul 2008

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Categorization derived from National Library of Medicine.
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