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   Drugs and Chemicals /  H   Haloperidol (Haldol)

A phenyl-piperidinyl-butyrophenone that is used primarily to treat schizophrenia and other psychoses. It is also used in schizoaffective disorder, delusional disorders, ballism, and Tourette syndrome (a drug of choice) and occasionally as adjunctive therapy in mental retardation and the chorea of Huntington disease. It is a potent antiemetic and is used in the treatment of intractable hiccups.


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   Related Disorders   

Schizophrenia
A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, hallucinations, emotional disharmony, and regressive behavior.
[ Articles]
Tourette Syndrome
A neuropsychological disorder related to alterations in dopamine metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with tics occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or a general medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning.
[ Articles]




 Pharmacologic Action
  • Antipsychotic Agent
    Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in schizophrenia, senile dementia, transient psychosis following surgery or myocardial infarction, etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.
  • Antiemetic
    Drugs used to prevent nausea or vomiting. Antiemetics act by a wide range of mechanisms. Some act on the medullary control centers (the vomiting center and the chemoreceptive trigger zone) while others affect the peripheral receptors.





Free Full Text 20 Jul 2008
Acute weight gain, gender, and therapeutic response to antipsychotics in the treatment of patients with schizophrenia
Previous research indicated that women are more vulnerable than men to adverse psychological consequences of weight gain. Other research has suggested that weight gain experienced during antipsychotic therapy may also psychologically impact women more negatively. This study assessed the impact of acute treatment-emergent weight gain on clinical and functional outcomes of patients with schizophrenia by patient gender and antipsychotic treatment (olanzapine or haloperidol).
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Relapse in patients with schizophrenia: a comparison between risperidone and haloperidol
Objectives:
To compare rates of rehospitalization and time to relapse in risperidone vs. haloperidol treated schizophrenic patients discharged from the hospital.
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Ethnicity and prescription patterns for haloperidol, risperidone, and olanzapine
Patients with schizophrenia may respond better to second-generation antipsychotics than to older antipsychotics because of their superior efficacy and safety profiles. However, the reduced likelihood among ethnic minority groups of receiving newer antipsychotics may be associated with reduced medication adherence and health service use, potentially contributing to poor response rates. This study examined whether ethnicity helped predict whether patients with schizophrenia were given a first- or a second-generation antipsychotic, haloperidol versus risperidone or olanzapine, and what type of second-generation antipsychotic was prescribed, risperidone or olanzapine, when other factors were controlled for.
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Latest News on Schizophrenia 20 Jul 2008
schizophrenia - Google News
schizophrenia - Google News

Partially Shared Genetic Profile Between Schizophrenia And Bipolar ... - Science Daily (press release)

Partially Shared Genetic Profile Between Schizophrenia And Bipolar ...
Science Daily (press release) - Jul 17, 2008
ScienceDaily (July 17, 2008) ? Both schizophrenia and bipolar disorder can be disabling conditions, and both present clinically with significant mood and ...
Association Between Genetic Variation And Antidepressant Treatment ... Medical News Today (press release)
Using Genetics To Improve Traditional Psychiatric Diagnoses Science Daily (press release)
all 13 news articles

Extended-Release Paliperidone Resolves Schizophrenia Exacerbations ... - DG News

Extended-Release Paliperidone Resolves Schizophrenia Exacerbations ...
DG News - Jul 18, 2008
By Bryan DeBusk, PhD MUNICH, Germany -- July 18, 2008 -- Patients hospitalised for acute exacerbations of schizophrenia who received extended-release ...

Asenapine as Effective as Olanzapine for Treating Schizophrenia ... - DG News

Asenapine as Effective as Olanzapine for Treating Schizophrenia ...
DG News - Jul 18, 2008
By Bryan DeBusk, PhD MUNICH, Germany -- July 18, 2008 -- Asenapine provides results similar to olanzapine in adults with schizophrenia, but patients taking ...

Time to be happy - Business Standard

Time to be happy
Business Standard, India - 12 hours agoPsychiatrists now claim that babies whose mothers have suffered severe stress during pregnancy are at a greater risk of developing schizophrenia in the long ...
Incorrectly Cleaved Protein Leads To Schizophrenia - Science Daily (press release)

Incorrectly Cleaved Protein Leads To Schizophrenia
Science Daily (press release) - Jul 14, 2008
ScienceDaily (July 14, 2008) ? The causes of schizophrenia are not yet clear. But now, VIB researchers connected to the Katholieke Universiteit Leuven have ...

Aripiprazole Safe for Schizophrenia or Bipolar 1 Disorder in ... - DG News

Aripiprazole Safe for Schizophrenia or Bipolar 1 Disorder in ...
DG News - Jul 17, 2008
By Bryan DeBusk ¶ MUNICH, Germany -- July 17, 2008 -- Treatment with aripiprazole 2 to 30 mg daily for 26 weeks is safe in adolescents with schizophrenia or ...

Schizophrenia discovery opens path to new treatments - Telegraph.co.uk

Schizophrenia discovery opens path to new treatments
Telegraph.co.uk, United Kingdom - Jul 14, 2008
By Roger Highfield Schizophrenia has been linked to a split protein, opening a path to a new class of treatments for the common mental illness. ...

Perceptions about the cause of schizophrenia and the subsequent ... - 7thSpace Interactive (press release)

Perceptions about the cause of schizophrenia and the subsequent ...
7thSpace Interactive (press release), NY - Jul 17, 2008
There is a cultural variability around the perception of what causes the syndrome of schizophrenia. Generally patients with schizophrenia are considered ...

Gentry's death horrendous, Bishop's life history tragic - Northeast Mississippi Daily Journal

Gentry's death horrendous, Bishop's life history tragic
Northeast Mississippi Daily Journal, MS - 18 hours ago
Her brother was diagnosed with schizophrenia and her sister suffers from post-traumatic stress disorder. Dale's father, Roy, was an alcoholic who became ...

Association study of polymorphisms inthe neutral amino acid ... - 7thSpace Interactive (press release)

Association study of polymorphisms inthe neutral amino acid ...
7thSpace Interactive (press release), NY - Jul 18, 2008
Based on the glutamatergic dysfunction hypothesis for schizophrenia pathogenesis, we have been performing systematic association studies of schizophrenia ...



 

Book Reviews 20 Jul 2008

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