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  Drugs and Chemicals /  A   Atenolol (ICI-66082, Tenormin , Tenormine)

A cardioselective beta-adrenergic blocker possessing properties and potency similar to Propranolol, but without a negative inotropic effect.

References:
   Related Disorders   

Hypertension
Persistently high systemic arterial blood pressure. Based on multiple readings , hypertension is currently defined as when systolic pressure is consistently greater than 140 mm Hg or when diastoloc pressure is consistently 90 mm Hg or more.
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 Pharmacologic Action
  • Adrenergic Beta Antagonist
    (Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.)
  • Anti Arrhythmia Agent
    (Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.)
  • Antihypertensive Agent
    (Drugs used in the treatment of acute or chronic hypertension regardless of pharmacological mechanism. Among the antihypertensive agents are Diuretics (especially Thiazide Diuretics), Adrenergic Beta Antagonists; Adrenergic Alpha Antagonists; Angiotensin Converting Enzyme Inhibitors; Calcium Channel Blockers; Ganglionic Blockers; and Vasodilator Agents.)
  • Sympatholytic
    (Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the Adrenergic Antagonists and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals. Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists,) are included here.)

   Tenormin Tablets   

Active Ingredients :
Atenolol
Inactive Ingredients :
Magnesium Stearate
(Belongs to Stearic Acids -> A group of compounds that are derivatives of octadecanoic acid which is one of the most abundant fatty acids found in animal lipids)
Microcrystalline Cellulose
Sodium Starch Glycolate
(Act as excipients -> Usually inert substances added to a prescription in order to provide suitable consistency to the dosage form. These include binders, matrix, base or diluent in pills, tablets, creams, salves, etc.)
Povidone
(A polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle for pharmaceuticals; also used as blood volume expander.)

Free Full Text 17 May 2008
Critical appraissal: Should atenolol be the first choice for primary hypertension?
Atenolol is one of the most widely used beta blockers clinically, and has often been used as a reference drug in randomized controlled trials of hypertension. However, questions have been raised about atenolol as the best reference drug for comparisons with other antihypertensives. Thus, our aim was to systematically review the effect of atenolol on cardiovascular morbidity and mortality in hypertensive patients.
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Health and Personal Care Shop 17 May 2008

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Categorization derived from National Library of Medicine.
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