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Biaxin ®
Generic : Clarithromycin
Active Ingredients :
> Clarithromycin
A semisynthetic macrolide antibiotic derived from
erythromycin
that is active against a variety of microorganisms. It can inhibit protein synthesis in bacteria by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.
Inactive Ingredients :
Cellulosic polymers, croscarmellose sodium, magnesium stearate, povidone, propylene glycol, silicon dioxide, sorbic acid, sorbitan monooleate, stearic acid, talc, titanium dioxide, and vanillin.
Pharmacologic Action :
> Anti-Bacterial Agent
> Protein Synthesis Inhibitor
- Use in Dentistry :
The treatment of orofacial infections.
- Articles :
Sasaki J, Morishima T, Sakamoto H, Takai H, Ikeshima K, Shiiki K, Uematsu M, Morihana T, Tomita F, Noma H, et al.
Clinical evaluation of clarithromycin in treatment of acute dental infections. Comparative double-blind study using josamycin as the control.
(Jpn J Antibiot. 1989 Apr;42(4):983-1013.)
>Abstract
Inoue K, Kumakura S, Uchida M, Tsutsui T.
Effects of eight antibacterial agents on cell survival and expression of epithelial-cell- or cell-adhesion-related genes in human gingival epithelial cells.
(J Periodontal Res. 2004 Feb;39(1):50-8.)
>Full Text
Moore PA.
Dental therapeutic indications for the newer long-acting macrolide antibiotics.
(J Am Dent Assoc. 1999 Sep;130(9):1341-3.)
>Abstract
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