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whipple disease A chronic systemic infection by a gram-positive bacterium, Tropheryma whippelii, mainly affecting the small intestine but also the joints; cardiovascular system;and the central nervous system. The disease is characterized by fat deposits in the intestinal mucosa and lymph nodes, malabsorption, diarrhea with fatty stools, malnutrition, and arthritis.


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(Intestinal Lipodystrophy)

Articles



PubmedPrevalence of asymptomatic Tropheryma whipplei carriage among humans and nonhuman primates.
Authors:  Fenollar F, Trani M, Davoust B, Salle B, Birg ML, Rolain JM, Raoult D
Journal: J Infect Dis

PubmedRecurrent orbital inflammation and Whipple disease.
Authors:  Huerva V, Espinet R, Galindo C
Journal: Ocul Immunol Inflamm

Pubmed[Whipple's disease with segmental lesions in the proximal small intestine]
Authors:  Prassler R, Kempmann T, Vierling P
Journal: Dtsch Med Wochenschr

PubmedWhipple disease.
Authors:  Marth T, Schneider T
Journal: Curr Opin Gastroenterol

PubmedWhipple's disease: new aspects of pathogenesis and treatment.
Authors:  Schneider T, Moos V, Loddenkemper C, Marth T, Fenollar F, Raoult D
Journal: Lancet Infect Dis

PubmedProsthetic hip infection caused by Tropheryma whipplei.
Authors:  Cremniter J, Bauer T, Lortat-Jacob A, Vodovar D, Le Parc JM, Emile JF, Franc B, Sebbag P, Gaillard JL, Heym B
Journal: J Clin Microbiol

PubmedComment on: therapy for Whipple's disease.
Authors:  Bakkali N, Fenollar F, Rolain JM, Raoult D
Journal: J Antimicrob Chemother

PubmedTeaching NeuroImage: Oculomasticatory myorhythmia: pathognomonic phenomenology of Whipple disease.
Authors:  Revilla FJ, de la Cruz R, Khardori N, Espay AJ
Journal: Neurology

PubmedGenotyping reveals a wide heterogeneity of Tropheryma whipplei.
Authors:  Li W, Fenollar F, Rolain JM, Fournier PE, Feurle GE, Müller C, Moos V, Marth T, Altwegg M, Calligaris-Maibach RC, Schneider T, Biagi F, La Scola B, Raoult D
Journal: Microbiology

Pubmed[Wipple's disease: 100 years since description]
Authors:  Parfenov AI
Journal: Ter Arkh

PubmedPremature ovarian failure in suspected Whipple's disease.
Authors:  Ferrari S, Di Puppo F, Persico P, Ferrari A
Journal: Fertil Steril

PubmedAdvances in Tropheryma whipplei research: the rush to find biomarkers for Whipple's disease.
Authors:  Kowalczewska M, Raoult D
Journal: Future Microbiol

PubmedOrbital manifestation of whipple's disease: an atypical case.
Authors:  Lieger O, Otto S, Clemetson IA, Arnold M, Iizuka T
Journal: J Craniomaxillofac Surg

Pubmed[Aortic and mitral valve infective endocarditis caused by Tropheryma whipplei and with no gastrointestinal manifestations of Whipple's disease]
Authors:  Kolek M, Zaloudíková B, Freiberger T, Brát R
Journal: Klin Mikrobiol Infekc Lek

PubmedMycobacterium avium duodenal infection mimicking Whipple's disease in a patient with AIDS.
Authors:  Dray X, Vahedi K, Delcey V, Lavergne-Slove A, Raskine L, Bergmann JF, Marteau P
Journal: Endoscopy

PubmedCase studies to explore the pitfalls in the diagnosis of sarcoidosis.
Authors:  Schilstra A, Rottoli P, Jacobs JA, van Suylen RJ, Galluzzi P, Drent M
Journal: Sarcoidosis Vasc Diffuse Lung Dis

Pubmed[Whipple's disease]
Authors:  Seguy D
Journal: Gastroenterol Clin Biol

PubmedDiffuse cortical lesions with hemorrhage in cerebral Whipple's disease.
Authors:  Wu L, Wang X, Wei H, Li C, Jia J
Journal: Clin Neurol Neurosurg

PubmedWhipple disease revealed by musculocutaneous symptoms, with muscle biopsy cultures positive for Tropheryma whipplei.
Authors:  Vincent V, Zabraniecki L, Uro-Coste E, Lemaire O, Fournié B
Journal: Joint Bone Spine

PubmedWhipple's disease in mentally retarded patients: report of two cases.
Authors:  Pettersson A, van Winsen L, van Oosten B, Kramers C, van de Ven A, Savelkoul P, van Agtmael M
Journal: Scand J Infect Dis

PubmedIsolated CNS Whipple disease with a variant of oculofacial-skeletal myorhythmia (OFSM).
Authors:  de Andrade DC, Nogueira RC, Lucato LT, Marchiori PE, Machado LR, Teixeira MJ, Scaff M
Journal: Neurology

PubmedWhipple's disease and sarcoidosis.
Authors:  Heffner DK
Journal: Lancet

Pubmed[Tonsillar hypertrophy and mesenteric adenopathies as the main manifestations in a patient with Whipple's disease]
Authors:  Cosme Jiménez A, Ojeda Pérez E, Neira F, Vaquero Pérez M, Bujanda Fernández de Piérola L, Montalvo I, Muro Carral N
Journal: Gastroenterol Hepatol

Pubmed[Extraintestinal manifestations in Whipple's disease]
Authors:  Ynfante Ferrús M, Rodríguez Ortega P, Pallarés Manrique H, Domínguez Macías A
Journal: Gastroenterol Hepatol

PubmedTherapy for Whipple's disease.
Authors:  Knaapen HK, Barrera P
Journal: J Antimicrob Chemother

PubmedCapsule endoscopic appearance of the small-intestinal mucosa in Whipple's disease and the changes that occur during antibiotic therapy.
Authors:  Dzirlo L, Blaha B, Müller C, Hubner M, Kneussl M, Huber K, Gschwantler M
Journal: Endoscopy

PubmedUltrastructural evidence of Tropheryma whippelii in PAS-negative granulomatous lymph nodes.
Authors:  Finzi G, Franzi F, Sessa F, Mastaglio C, Capella C
Journal: Ultrastruct Pathol

Pubmed[Whipple's disease: current problems]
Authors:  Muzes G, Székely H, Tulassay Z
Journal: Orv Hetil

PubmedIsolated CNS Whipple disease: acute onset and relapsing-remitting course.
Authors:  Benito-León J, Arpa J, Louis ED, Herrera I, De La Loma A
Journal: Scand J Infect Dis

PubmedA systematic literature review of psychological factors and the development of late whiplash syndrome.
Authors:  Williamson E, Williams M, Gates S, Lamb SE
Journal: Pain

PubmedWhipple of the Whipple operation.
Authors:  Haubrich WS
Journal: Gastroenterology

PubmedFalse positive PCR detection of Tropheryma whipplei in the saliva of healthy people.
Authors:  Rolain JM, Fenollar F, Raoult D
Journal: BMC Microbiol

PubmedA mimic of sarcoidosis.
Authors:  Dzirlo L, Hubner M, Müller C, Blaha B, Formann E, Dellinger C, Petzelbauer P, Müllauer L, Huber K, Kneussl M, Gschwantler M
Journal: Lancet

Pubmed[Refractory intermediate uveitis in the presence of unexplained joint disease. Diagnosis: Tropheryma whipplei (Morbus Whipple)]
Authors:  Mennel S, Schubert S, Müller C
Journal: Ophthalmologe

PubmedRe: "Whipple's disease redux.
Authors:  Sataline L
Journal: Conn Med

PubmedCultivation of Tropheryma whipplei from the synovial fluid in Whipple's arthritis.
Authors:  Puéchal X, Fenollar F, Raoult D
Journal: Arthritis Rheum

PubmedTropheryma whipplei infective endocarditis as the only manifestation of Whipple's disease.
Authors:  Marín M, Muñoz P, Sánchez M, del Rosal M, Rodríguez-Créixems M, Bouza E,  
Journal: J Clin Microbiol

PubmedWhipple's disease.
Authors:  Bramkamp M, Ruggieri F, Schneemann M
Journal: N Engl J Med

PubmedWhipple's disease.
Authors:  Williams OM, Nightingale AK, Hartley J
Journal: N Engl J Med

Pubmed"Whipple's disease".
Authors:  Spiro H
Journal: Conn Med

PubmedEosinophilic vasculitis: a rare presentation of Whipple's disease.
Authors:  Al-Hamoudi W, Habbab F, Nudo C, Nahal A, Flegel K
Journal: Can J Gastroenterol

PubmedA patient with cerebral Whipple disease with gastric involvement but no gastrointestinal symptoms: a consequence of local protective immunity?
Authors:  Prüss H, Katchanov J, Zschenderlein R, Loddenkemper C, Schneider T, Moos V
Journal: J Neurol Neurosurg Psychiatry

PubmedNeck pain in chronic whiplash syndrome treated with botulinum toxin. A double-blind, placebo-controlled clinical trial.
Authors:  Padberg M, de Bruijn SF, Tavy DL
Journal: J Neurol

PubmedTwo common reasons of malabsorption syndromes: celiac disease and Whipple's disease.
Authors:  Sun DF, Fang JY
Journal: Digestion

PubmedRefractory Whipple's disease.
Authors:  Fernandez-Urien I, Carretero C, Sola JJ, Muñoz-Navas M, Betes M, Subtil JC, Armendariz R
Journal: Gastrointest Endosc

PubmedWhipple's disease redux.
Authors:  Sataline L
Journal: Conn Med

Pubmed[Potentially reversible dementia]
Authors:  Sellal F, Becker H
Journal: Presse Med

Pubmed[Whipple's disease]
Authors:  Marth T
Journal: Schweiz Rundsch Med Prax

PubmedSerial imaging changes of cerebral Whipple's disease: from onset to the end.
Authors:  Yu C, Jiang A, Yu Y
Journal: J Neuroimaging

PubmedClinical problem-solving. A stain in time.
Authors:  Jones J, Vellend H, Detsky AS, Mourad O
Journal: N Engl J Med

PubmedWhipple's disease.
Authors:  Fenollar F, Puéchal X, Raoult D
Journal: N Engl J Med

PubmedEducation and imaging. Gastrointestinal: Whipple's disease.
Authors:  Coli MV, Chebli JM, Gaburri PD
Journal: J Gastroenterol Hepatol

PubmedA case of Whipple disease with pleural effusion diagnosed by means of PCR.
Authors:  Garcia-Porrua C, Arias C, Veiga JA, Santos E, Gonzalez-Gay MA
Journal: Clin Exp Rheumatol

Pubmed[Scurvy and acquired ichthyosis associated to Whipple's disease]
Authors:  Juárez Y, España S, Fernández-Díaz ML, Lueiro M
Journal: Actas Dermosifiliogr

PubmedEndoscopic retrograde cholangiopancreatography in post-Whipple patients.
Authors:  Chahal P, Baron TH, Topazian MD, Petersen BT, Levy MJ, Gostout CJ
Journal: Endoscopy

PubmedWhipple's disease in a father-son pair.
Authors:  Ponz de Leon M, Borghi A, Ferrara F, Contri M, Roncucci L
Journal: Intern Emerg Med

Pubmed18F-fluorodeoxyglucose positron emission tomography in Whipple's disease.
Authors:  André MF, Delèvaux I, Cachin F, Fenollar F, Raoult D, Maublant J, Aumaître O
Journal: Scand J Gastroenterol

PubmedCurrent concepts of immunopathogenesis, diagnosis and therapy in Whipple's disease.
Authors:  Deriban G, Marth T
Journal: Curr Med Chem

PubmedProgressive supranuclear gaze palsy without parkinsonism: a case of neuro-Whipple.
Authors:  Magherini A, Pentore R, Grandi M, Leone ME, Nichelli PF
Journal: Parkinsonism Relat Disord

PubmedHypersomnia in Whipple disease: case report.
Authors:  Maia LF, Marta M, Lopes V, Rocha N, Lopes C, Martins-da-Silva A, Monteiro L
Journal: Arq Neuropsiquiatr

PubmedWhipple disease revisited: radiographic features of a patient with 35 years of undiagnosed arthritis.
Authors:  Scheib JS
Journal: J Clin Rheumatol

PubmedCulture of T. whipplei from the stool of a patient with Whipple's disease.
Authors:  Raoult D, Fenollar F, Birg ML
Journal: N Engl J Med

PubmedAnti-Ma2-associated encephalitis with normal FDG-PET: a case of pseudo-Whipple's disease.
Authors:  Castle J, Sakonju A, Dalmau J, Newman-Toker DE
Journal: Nat Clin Pract Neurol

PubmedProduction of monoclonal antibodies to Tropheryma whipplei and identification of recognized epitopes by two-dimensional electrophoresis and mass spectrometry.
Authors:  Yu Y, Kowalczewska M, Decloquement P, Nappez C, La Scola B
Journal: J Clin Microbiol

Pubmed[Whipple's disease and central nervous system]
Authors:  Bermejo P, Burgos A
Journal: Med Clin (Barc)

PubmedWhipple's disease with muscle impairment.
Authors:  Puget M, Iwaz J, Tristan A, Streichenberger N
Journal: Muscle Nerve

PubmedPrimary Whipple's disease of the brain: characterization of the clinical syndrome and molecular diagnosis.
Authors:  Panegyres PK, Edis R, Beaman M, Fallon M
Journal: QJM

PubmedMurine model of infection by Tropheryma whipplei.
Authors:  Genot S, Stein A, Lepidi H, Ihrig M, Raoult D, Mege JL
Journal: Infect Immun

PubmedReduced peripheral and mucosal Tropheryma whipplei-specific Th1 response in patients with Whipple's disease.
Authors:  Moos V, Kunkel D, Marth T, Feurle GE, LaScola B, Ignatius R, Zeitz M, Schneider T
Journal: J Immunol

Pubmed[At first joint pain, then diarrhea and under certain conditions dementia also: Whipple's disease is a chameleon]
Authors:  Stiefelhagen P
Journal: MMW Fortschr Med

PubmedGlobal transcriptome analysis of Tropheryma whipplei in response to temperature stresses.
Authors:  Crapoulet N, Barbry P, Raoult D, Renesto P
Journal: J Bacteriol

PubmedA case of cerebral Whipple's disease initially presenting with isolated focal myoclonus.
Authors:  Henning S, Tings T, Schmidt H, Tergau F, Wolf S, Scholz K, Knauth M, Buchner H, Gold R, Paulus W
Journal: Eur J Neurol

PubmedTropical sprue in two foreign residents, with evidence of Tropheryma whippelii in one case.
Authors:  Prendki V, Grandière-Perez L, Ansart S, Fenollar F, Bricaire F, Caumes E
Journal: J Travel Med

PubmedReversible hypothyroidism and Whipple's disease.
Authors:  Tran HA
Journal: BMC Endocr Disord

PubmedIdentification of candidate antigen in Whipple's disease using a serological proteomic approach.
Authors:  Kowalczewska M, Fenollar F, Lafitte D, Raoult D
Journal: Proteomics

PubmedDecision analysis: an aid to the diagnosis of Whipple's disease.
Authors:  Olmos M, Smecuol E, Mauriño E, Bai JC
Journal: Aliment Pharmacol Ther

PubmedWhipple's disease: a macrophage disease.
Authors:  Desnues B, Ihrig M, Raoult D, Mege JL
Journal: Clin Vaccine Immunol

Pubmed[Whipple's disease/Morbus Whipple. Main symptoms: fever, lymphadenopathy, arthralgia, weight loss, chronic diarrhea]
Authors:  Haltinner K, Nigg C, Kolyvanos Naumann U, Käser L, Vetter W
Journal: Schweiz Rundsch Med Prax

PubmedUnusual endoscopic presentation of Whipple's disease.
Authors:  Nahon S, Lesgourgues B, Delas N
Journal: Clin Gastroenterol Hepatol

PubmedIntestinal histoplasmosis mimicking Whipple's disease.
Authors:  McCullough K, Damjanov I
Journal: Histopathology

Pubmed[Whipple disease, initially diagnosed as sarcoidosis]
Authors:  Saba M, Rollot F, Park S, Grimaldi D, Sicard D, Abad S, Blanche P
Journal: Presse Med

Pubmed[Fever of unknown origin in the 21st century: infectious diseases]
Authors:  Schneider T, Loddenkemper C, Rudwaleit M, Lode H, Zeitz M
Journal: Dtsch Med Wochenschr

Pubmed[Whipple disease as a cause of fever of unknown origin]
Authors:  García A, Batlle C, Losada E, Selva A
Journal: Med Clin (Barc)

PubmedSmall-intestinal pathology on capsule endoscopy: miscellaneous.
Authors:  Pennazio M
Journal: Endoscopy

PubmedAssociation between Whipple's disease and Giardia lamblia infection.
Authors:  Gil Ruiz JA, Gil Simón P, Aparicio Duque R, Mayor Jerez JL
Journal: Rev Esp Enferm Dig

PubmedWhipple's DNA is not Whipple's disease.
Authors:  Schneemann M, Schoedon G
Journal: J Clin Microbiol

Pubmed[Whipple disease and central nervous system]
Authors:  Abreu P, Azevedo E, Lobo L, Moura CS, Pontes C
Journal: Acta Med Port

PubmedWhipple disease: intestinal infiltrating cells exhibit a transcriptional pattern of M2/alternatively activated macrophages.
Authors:  Desnues B, Lepidi H, Raoult D, Mege JL
Journal: J Infect Dis

Pubmed[Whipple's disease--a challenging diagnosis]
Authors:  Carneiro AC, Lima P, Barbosa IP, Chaves FC
Journal: Acta Med Port

PubmedSynchronous malakoplakia and Whipple's disease.
Authors:  Cachia AR, Eshoo S, Kench J, Fung C, Jones A, Iredell J, Don G
Journal: Pathology

PubmedIL-16 is critical for Tropheryma whipplei replication in Whipple's disease.
Authors:  Desnues B, Raoult D, Mege JL
Journal: J Immunol

Pubmed[Whipple's disease endocarditis: report of 5 cases and review of the literature]
Authors:  Aïouaz H, Célard M, Puget M, Vandenesch F, Mercusot A, Fenollar F, Delahaye F, Obadia JF, Tebib J, Rousset H
Journal: Rev Med Interne

PubmedModels for estimating bayes factors with applications to phylogeny and tests of monophyly.
Authors:  Suchard MA, Weiss RE, Sinsheimer JS
Journal: Biometrics

Pubmed[The farmer's wife will not exceed the limit!]
Authors:  Geffray L, Artigues N, Boutemy J, Poynard JP, Paris C, Armand P, Bonnefoy L, Alric L
Journal: Rev Med Interne

Pubmed[One name, two physicians. About Whipple's procedure and Whipple's disease]
Authors:  Wysocki WM, Komorowski AL, Wysocki A
Journal: Przegl Lek

PubmedExacerbation of Whipple's disease associated with infliximab treatment.
Authors:  Kneitz C, Suerbaum S, Beer M, Müller J, Jahns R, Tony HP
Journal: Scand J Rheumatol

PubmedAn unusual case of insomnia associated with Whipple encephalopathy: first case reported from Greece.
Authors:  Papadopoulou M, Rentzos M, Vagiakis E, Zouvelou V, Potagas C, Bonakis A, Chatzipanagiotou S, Ioannidis A, Nicolaou C, Vassilopoulos D
Journal: Neurol Sci

PubmedWhipple's endocarditis.
Authors:  West D, Hutcheon S, Kain R, Reid T, Walton S, Buchan K
Journal: J R Soc Med

PubmedWhipple's disease: multiple hospital admissions of a man with diarrhoea, fever and arthralgia.
Authors:  Magira EE, Gounaris T, Sioula E
Journal: J Infect

PubmedA patient with cerebral Whipple's disease and a stroke-like syndrome.
Authors:  Famularo G, Minisola G, De Simone C
Journal: Scand J Gastroenterol





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