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| wallerian degeneration |
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Degeneration of distal aspects of a nerve axon following injury to the cell body or proximal portion of the axon.
The process is characterized by fragmentation of the axon and its myelin sheath.
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Additional comments :
Nerve Degeneration
Retrograde Degeneration
Subacute Combined Degeneration
Wallerian Degeneration
Articles
Nmnat delays axonal degeneration caused by mitochondrial and oxidative stress. Authors: Press C, Milbrandt J Journal: J Neurosci
Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling. Authors: Ziegenfuss JS, Biswas R, Avery MA, Hong K, Sheehan AE, Yeung YG, Stanley ER, Freeman MR Journal: Nature
An autopsy case of Fabry disease with neuropathological investigation of the pathogenesis of associated dementia. Authors: Okeda R, Nisihara M Journal: Neuropathology
Syncytial coupling of neurons in tissue culture and early ontogenesis. Authors: Sotnikov OS, Malashko VV, Rybakova GI Journal: Neurosci Behav Physiol
High resolution X-ray phase contrast synchrotron imaging of normal and ligation damaged rat sciatic nerves. Authors: Kim BI, Kim KH, Youn HS, Jheon S, Kim JK, Kim H Journal: Microsc Res Tech
Synapse involvement of the dorsal horn in experimental lumbar nerve root compression: a light and electron microscopic study. Authors: Kobayashi S, Uchida K, Kokubo Y, Takeno K, Yayama T, Miyazaki T, Nakajima H, Nomura E, Mwaka E, Baba H Journal: Spine
Schwann cell proliferation during Wallerian degeneration is not necessary for regeneration and remyelination of the peripheral nerves: axon-dependent removal of newly generated Schwann cells by apoptosis. Authors: Yang DP, Zhang DP, Mak KS, Bonder DE, Pomeroy SL, Kim HA Journal: Mol Cell Neurosci
Soluble complement receptor 1 protects the peripheral nerve from early axon loss after injury. Authors: Ramaglia V, Wolterman R, de Kok M, Vigar MA, Wagenaar-Bos I, King RH, Morgan BP, Baas F Journal: Am J Pathol
Autosomal dominant sensory ataxia: a neuroaxonal dystrophy. Authors: Moeller JJ, Macaulay RJ, Valdmanis PN, Weston LE, Rouleau GA, Dupré N Journal: Acta Neuropathol
Changes in excitability properties associated with axonal regeneration in human neuropathy and mouse Wallerian degeneration. Authors: Sawai S, Kanai K, Nakata M, Hiraga A, Misawa S, Isose S, Hattori T, Kuwabara S Journal: Clin Neurophysiol
Retrograde Wallerian degeneration of cranial corticospinal tracts in cervical spinal cord injury patients using diffusion tensor imaging. Authors: Guleria S, Gupta RK, Saksena S, Chandra A, Srivastava RN, Husain M, Rathore R, Narayana PA Journal: J Neurosci Res
Neurogenic bladder due to hypoxic-ischemic demyelination. Authors: Ramchandren S, Liebeskind DS Journal: J Neuroimaging
Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice with a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene. Authors: Sakurai M, Sekiguchi M, Zushida K, Yamada K, Nagamine S, Kabuta T, Wada K Journal: Eur J Neurosci
Teaching NeuroImage: Cervical cord atrophy with dorsal root ganglionopathy in Sjögren syndrome. Authors: Lin CC, Chiu MJ Journal: Neurology
Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degeneration. Authors: Palin K, Cunningham C, Forse P, Perry VH, Platt N Journal: Neurobiol Dis
Longitudinal investigations on the anterograde and retrograde degeneration in the pyramidal tract following pontine infarction with diffusion tensor imaging. Authors: Liang Z, Zeng J, Zhang C, Liu S, Ling X, Xu A, Ling L, Wang F, Pei Z Journal: Cerebrovasc Dis
Contuse lesion of the rat spinal cord of moderate intensity leads to a higher time-dependent secondary neurodegeneration than severe one. An open-window for experimental neuroprotective interventions. Authors: Andrade MS, Hanania FR, Daci K, Leme RJ, Chadi G Journal: Tissue Cell
Postnatal Schwann cell proliferation but not myelination is strictly and uniquely dependent on cyclin-dependent kinase 4 (cdk4). Authors: Atanasoski S, Boentert M, De Ventura L, Pohl H, Baranek C, Beier K, Young P, Barbacid M, Suter U Journal: Mol Cell Neurosci
Nerve allograft transplantation: a review. Authors: Siemionow M, Sonmez E Journal: J Reconstr Microsurg
Evolving Wallerian degeneration after transient retinal ischemia in mice characterized by diffusion tensor imaging. Authors: Sun SW, Liang HF, Cross AH, Song SK Journal: Neuroimage
Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma. Authors: Howell GR, Libby RT, Jakobs TC, Smith RS, Phalan FC, Barter JW, Barbay JM, Marchant JK, Mahesh N, Porciatti V, Whitmore AV, Masland RH, John SW Journal: J Cell Biol
[In vivo characterization of sonic hedgehog in the peripheral nerve regeneration] Authors: Akazawa C, Kohsaka S Journal: Brain Nerve
Phagocytes of the transected feline optic nerve: an ultrastructural study. Authors: Chew S Journal: J Electron Microsc (Tokyo)
GJA12 mutations are a rare cause of Pelizaeus-Merzbacher-like disease. Authors: Henneke M, Combes P, Diekmann S, Bertini E, Brockmann K, Burlina AP, Kaiser J, Ohlenbusch A, Plecko B, Rodriguez D, Boespflug-Tanguy O, Gärtner J Journal: Neurology
Positive and negative implications of tumor necrosis factor neutralization for the pathogenesis of multiple sclerosis. Authors: Taoufik E, Tseveleki V, Euagelidou M, Emmanouil M, Voulgari-Kokota A, Haralambous S, Probert L Journal: Neurodegener Dis
Comparison of cytokine expression profile during Wallerian degeneration of myelinated and unmyelinated peripheral axons. Authors: Cheepudomwit T, Güzelsu E, Zhou C, Griffin JW, Höke A Journal: Neurosci Lett
Gadofluorine M-enhanced magnetic resonance nerve imaging: comparison between acute inflammatory and chronic degenerative demyelination in rats. Authors: Wessig C, Jestaedt L, Sereda MW, Bendszus M, Stoll G Journal: Exp Neurol
Calpain-mediated cleavage of collapsin response mediator protein(CRMP)-2 during neurite degeneration in mice. Authors: Touma E, Kato S, Fukui K, Koike T Journal: Eur J Neurosci
Role of immunity in recovery from a peripheral nerve injury. Authors: Sanders VM, Jones KJ Journal: J Neuroimmune Pharmacol
TGF-beta1 and TGF-beta2 expression after traumatic human spinal cord injury. Authors: Buss A, Pech K, Kakulas BA, Martin D, Schoenen J, Noth J, Brook GA Journal: Spinal Cord
Axon & dendrite degeneration: its mechanisms and protective experimental paradigms. Authors: Koike T, Yang Y, Suzuki K, Zheng X Journal: Neurochem Int
Prion propagation in a nerve conduit model containing segments devoid of axons. Authors: Kratzel C, Krüger D, Beekes M Journal: J Gen Virol
Poststroke cerebral peduncular atrophy correlates with a measure of corticospinal tract injury in the cerebral hemisphere. Authors: Mark VW, Taub E, Perkins C, Gauthier LV, Uswatte G, Ogorek J Journal: AJNR Am J Neuroradiol
Hyperglycaemia inhibits Schwann cell proliferation and migration and restricts regeneration of axons and Schwann cells from adult murine DRG. Authors: Gumy LF, Bampton ET, Tolkovsky AM Journal: Mol Cell Neurosci
Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury. Authors: Boivin A, Pineau I, Barrette B, Filali M, Valličres N, Rivest S, Lacroix S Journal: J Neurosci
Design of a novel quantitative PCR (QPCR)-based protocol for genotyping mice carrying the neuroprotective Wallerian degeneration slow (Wlds) gene. Authors: Wishart TM, Macdonald SH, Chen PE, Shipston MJ, Coleman MP, Gillingwater TH, Ribchester RR Journal: Mol Neurodegener
Morphology and morphometry in chronic spinal cord injury assessed using diffusion tensor imaging and fuzzy logic. Authors: Ellingson BM, Ulmer JL, Prost RW, Schmit BD Journal: Conf Proc IEEE Eng Med Biol Soc
Increased invasion of ED-1 positive macrophages in both ipsi- and contralateral dorsal root ganglia following unilateral nerve injuries. Authors: Dubový P, Tucková L, Jancálek R, Svízenská I, Klusáková I Journal: Neurosci Lett
Diffusion tensor imaging in patients with essential tremor. Authors: Shin DH, Han BS, Kim HS, Lee PH Journal: AJNR Am J Neuroradiol
Wallerian degeneration of the corticospinal tract in a middle cerebral artery infarction. Authors: Fleck JD, Azzarelli B, Biller J Journal: J Stroke Cerebrovasc Dis
Patients with capsular infarct and Wallerian degeneration show persistent regional premotor cortex activation on functional magnetic resonance imaging. Authors: Miyai I, Suzuki T, Mikami A, Kubota K, Volpe BT Journal: J Stroke Cerebrovasc Dis
Multiple system atrophy (MSA) with massive macrophage infiltration in the ponto-cerebellar afferent system. Authors: Yokoyama T, Hasegawa K, Horiuchi E, Yagishita S Journal: Neuropathology
Development of a cell transducible RhoA inhibitor TAT-C3 transferase and its encapsulation in biocompatible microspheres to promote survival and enhance regeneration of severed neurons. Authors: Tan EY, Law JW, Wang CH, Lee AY Journal: Pharm Res
Denervation of skin in neuropathies: the sequence of axonal and Schwann cell changes in skin biopsies. Authors: Ebenezer GJ, McArthur JC, Thomas D, Murinson B, Hauer P, Polydefkis M, Griffin JW Journal: Brain
Dynamic remodelling of synapses can occur in the absence of the parent cell body. Authors: Bettini NL, Moores TS, Baxter B, Deuchars J, Parson SH Journal: BMC Neurosci
Local tissue reactions after nerve repair with ethyl-cyanoacrylate compared with epineural sutures. Authors: Landegren T, Risling M, Persson JK Journal: Scand J Plast Reconstr Surg Hand Surg
CCL5 and CCR5 genotypes modify clinical, radiological and pathological features of multiple sclerosis. Authors: van Veen T, Nielsen J, Berkhof J, Barkhof F, Kamphorst W, Bö L, Ravid R, Verweij CL, Huitinga I, Polman CH, Uitdehaag BM Journal: J Neuroimmunol
Distinct types of microglial activation in white and grey matter of rat lumbosacral cord after mid-thoracic spinal transection. Authors: McKay SM, Brooks DJ, Hu P, McLachlan EM Journal: J Neuropathol Exp Neurol
The morbidity and outcome of patients with Guillain-Barré syndrome admitted to the intensive care unit. Authors: Dhar R, Stitt L, Hahn AF Journal: J Neurol Sci
Prominent brain axonal damage and functional reorganization in "pure" adrenomyeloneuropathy. Authors: Marino S, De Luca M, Dotti MT, Stromillo ML, Formichi P, Galluzzi P, Mondelli M, Bramanti P, Federico A, De Stefano N Journal: Neurology
Lack of adrenoleukodystrophy protein enhances oligodendrocyte disturbance and microglia activation in mice with combined Abcd1/Mag deficiency. Authors: Dumser M, Bauer J, Lassmann H, Berger J, Forss-Petter S Journal: Acta Neuropathol
PD-L1 (B7-H1) regulation in zones of axonal degeneration. Authors: Lipp M, Brandt C, Dehghani F, Kwidzinski E, Bechmann I Journal: Neurosci Lett
Targeting inflammatory demyelinating lesions to sites of Wallerian degeneration. Authors: Tsunoda I, Tanaka T, Saijoh Y, Fujinami RS Journal: Am J Pathol
Mechanisms of axon degeneration: from development to disease. Authors: Saxena S, Caroni P Journal: Prog Neurobiol
Changes in mRNA for CAPON and Dexras1 in adult rat following sciatic nerve transection. Authors: Shen A, Chen M, Niu S, Sun L, Gao S, Shi S, Li X, Lv Q, Guo Z, Cheng C Journal: J Chem Neuroanat
Time course of preferential motor unit loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis. Authors: Hegedus J, Putman CT, Gordon T Journal: Neurobiol Dis
Rho kinase inhibitor improves motor dysfunction and hypoalgesia in a rat model of lumbar spinal canal stenosis. Authors: Ito T, Ohtori S, Hata K, Inoue G, Moriya H, Takahashi K, Yamashita T Journal: Spine
Small-fiber involvement in spinobulbar muscular atrophy (Kennedy's disease). Authors: Manganelli F, Iodice V, Provitera V, Pisciotta C, Nolano M, Perretti A, Santoro L Journal: Muscle Nerve
Spinal cord injury-induced expression of the antiangiogenic endostatin/collagen XVIII in areas of vascular remodelling. Authors: Mueller CA, Conrad S, Schluesener HJ, Pietsch T, Schwab JM Journal: J Neurosurg Spine
Antibodies against light neurofilaments in multiple sclerosis patients. Authors: Bartos A, Fialová L, Soukupová J, Kukal J, Malbohan I, Pitha J Journal: Acta Neurol Scand
Chemotherapy-evoked neuropathic pain: Abnormal spontaneous discharge in A-fiber and C-fiber primary afferent neurons and its suppression by acetyl-L-carnitine. Authors: Xiao WH, Bennett GJ Journal: Pain
Inhibiting effect of minocycline on the regeneration of peripheral nerves. Authors: Keilhoff G, Langnaese K, Wolf G, Fansa H Journal: Dev Neurobiol
The membrane attack complex of the complement system is essential for rapid Wallerian degeneration. Authors: Ramaglia V, King RH, Nourallah M, Wolterman R, de Jonge R, Ramkema M, Vigar MA, van der Wetering S, Morgan BP, Troost D, Baas F Journal: J Neurosci
The relationship between white matter brain metabolites and cognition in normal aging: the GENIE study. Authors: Charlton RA, McIntyre DJ, Howe FA, Morris RG, Markus HS Journal: Brain Res
Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury. Authors: Terayama R, Bando Y, Murakami K, Kato K, Kishibe M, Yoshida S Journal: Neuroscience
The mRNA of transferrin is expressed in Schwann cells during their maturation and after nerve injury. Authors: Salis C, Setton CP, Soto EF, Pasquini JM Journal: Exp Neurol
Extent of nerve cell injury in Marmarou's model compared to other brain trauma models. Authors: Rafols JA, Morgan R, Kallakuri S, Kreipke CW Journal: Neurol Res
Wallerian degeneration of the corticospinal tracts: postmortem MR-pathologic correlations. Authors: Matsusue E, Sugihara S, Fujii S, Kinoshita T, Ohama E, Ogawa T Journal: Acta Radiol
Augustus Waller and the case of the disappearing axon. Authors: Griffin JW Journal: Nat Clin Pract Neurol
Spinal pathways involved in the control of forelimb motor function in rats. Authors: Anderson KD, Gunawan A, Steward O Journal: Exp Neurol
Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury. Authors: Ai J, Liu E, Wang J, Chen Y, Yu J, Baker AJ Journal: J Neurotrauma
Wallerian-like degeneration after ischemic stroke revealed by diffusion--weighted imaging. Authors: Sylaja RN, Goyal M, Watson T, Hill MD Journal: Can J Neurol Sci
Contribution of calcium channel subtypes to the intracellular calcium signal in sensory neurons: the effect of injury. Authors: Fuchs A, Rigaud M, Sarantopoulos CD, Filip P, Hogan QH Journal: Anesthesiology
Painful nerve injury shortens the intracellular Ca2+ signal in axotomized sensory neurons of rats. Authors: Fuchs A, Rigaud M, Hogan QH Journal: Anesthesiology
[Wallerian degeneration after stroke: a new prognostic factor?] Authors: Soares-Fernandes J, Beleza P, Ribeiro M, Maré R, Almeida F, Rocha J Journal: Acta Med Port
[Syncytial coupling of neurons in tissue culture and in early ontogenesis] Authors: Sotnikov OS, Malashko VV, Rybakova GI Journal: Morfologiia
Mammalian Sir2-related protein (SIRT) 2-mediated modulation of resistance to axonal degeneration in slow Wallerian degeneration mice: a crucial role of tubulin deacetylation. Authors: Suzuki K, Koike T Journal: Neuroscience
Resveratrol abolishes resistance to axonal degeneration in slow Wallerian degeneration (WldS) mice: activation of SIRT2, an NAD-dependent tubulin deacetylase. Authors: Suzuki K, Koike T Journal: Biochem Biophys Res Commun
Neuroimaging in multiple sclerosis. Authors: Zivadinov R, Cox JL Journal: Int Rev Neurobiol
Longitudinal changes in global brain volume between 79 and 409 days after traumatic brain injury: relationship with duration of coma. Authors: Trivedi MA, Ward MA, Hess TM, Gale SD, Dempsey RJ, Rowley HA, Johnson SC Journal: J Neurotrauma
Bilateral white matter diffusion changes persist after epilepsy surgery. Authors: Concha L, Beaulieu C, Wheatley BM, Gross DW Journal: Epilepsia
Wallerian degeneration of the corticofugal tracts in chronic stroke: a pilot study relating diffusion tensor imaging, transcranial magnetic stimulation, and hand function. Authors: Lindberg PG, Skejř PH, Rounis E, Nagy Z, Schmitz C, Wernegren H, Bring A, Engardt M, Forssberg H, Borg J Journal: Neurorehabil Neural Repair
Why is Wallerian degeneration in the CNS so slow? Authors: Vargas ME, Barres BA Journal: Annu Rev Neurosci
Enhanced visualization of axonopathy in EAE using thy1-YFP transgenic mice. Authors: Bannerman PG, Hahn A Journal: J Neurol Sci
Amyloid fibrils of mammalian prion protein induce axonal degeneration in NTERA2-derived terminally differentiated neurons. Authors: Novitskaya V, Makarava N, Sylvester I, Bronstein IB, Baskakov IV Journal: J Neurochem
Differential proteomics analysis of synaptic proteins identifies potential cellular targets and protein mediators of synaptic neuroprotection conferred by the slow Wallerian degeneration (Wlds) gene. Authors: Wishart TM, Paterson JM, Short DM, Meredith S, Robertson KA, Sutherland C, Cousin MA, Dutia MB, Gillingwater TH Journal: Mol Cell Proteomics
Early effects of neuropathy-inducing organophosphates on in vivo concentrations of three neurotrophins. Authors: Pomeroy-Black MJ, Jortner BS, Ehrich MF Journal: Neurotox Res
The neuroprotective effects of the WldS gene are correlated with proteasome expression rather than apoptosis. Authors: Simonin Y, Ferrer-Alcon M, Ferri A, Kato AC Journal: Eur J Neurosci
Hyperbaric oxygenation in peripheral nerve repair and regeneration. Authors: Sanchez EC Journal: Neurol Res
Compressive cervical myelopathy in young Texel and Beltex sheep. Authors: Penny C, Macrae A, Hagen R, Hahn C, Sargison N, Scott P, Smith S, Wilson D, Mayhew J Journal: J Vet Intern Med
Correlation of diffusion tensor and dynamic perfusion MR imaging metrics in normal-appearing corpus callosum: support for primary hypoperfusion in multiple sclerosis. Authors: Saindane AM, Law M, Ge Y, Johnson G, Babb JS, Grossman RI Journal: AJNR Am J Neuroradiol
The effect of low-dose insulin on mechanical sensitivity and allodynia in type I diabetes neuropathy. Authors: Hoybergs YM, Meert TF Journal: Neurosci Lett
Origin of fatigue in multiple sclerosis: review of the literature. Authors: Kos D, Kerckhofs E, Nagels G, D'hooghe MB, Ilsbroukx S Journal: Neurorehabil Neural Repair
Axonal involvement in the Wlds neuroprotective effect: analysis of pure motoneurons in a mouse model protected from motor neuron disease at a pre-symptomatic age. Authors: Simonin Y, Perrin FE, Kato AC Journal: J Neurochem
SIRT1 and neuronal diseases. Authors: Tang BL, Chua CE Journal: Mol Aspects Med
Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing. Authors: White SR, Evans KJ, Lary J, Cole JL, Lauring B Journal: J Cell Biol
Nogo-A is involved in secondary axonal degeneration of thalamus in hypertensive rats with focal cortical infarction. Authors: Wang F, Liang Z, Hou Q, Xing S, Ling L, He M, Pei Z, Zeng J Journal: Neurosci Lett
Assessing "occult" cervical cord damage in patients with neuropsychiatric systemic lupus erythematosus using diffusion tensor MRI. Authors: Benedetti B, Rovaris M, Judica E, Donadoni G, Ciboddo G, Filippi M Journal: J Neurol Neurosurg Psychiatry
Acupuncture treatment improves nerve conduction in peripheral neuropathy. Authors: Schröder S, Liepert J, Remppis A, Greten JH Journal: Eur J Neurol
Ventricular cerebrospinal fluid neurofilament protein levels decrease in parallel with white matter pathology after shunt surgery in normal pressure hydrocephalus. Authors: Tullberg M, Blennow K, Mĺnsson JE, Fredman P, Tisell M, Wikkelsö C Journal: Eur J Neurol
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