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| tanacetum parthenium |
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An aromatic perennial plant species that has been used to treat migraines, arthritis, and as a febrifuge. It contains tannins, volatile oils, and sesquiterpene lactones, especially parthenolide.
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Additional comments :
(Chrysanthemum parthenium, Feverfew)
Articles
 Selected Physical and Chemical Properties of Feverfew (Tanacetum parthenium) Extracts Important for Formulated Product Quality and Performance.
Authors: Jin P, Madieh S, Augsburger LL
Journal: AAPS PharmSciTech
Parthenolide induces apoptosis in glioblastomas without affecting NF-kappaB.
Authors: Anderson KN, Bejcek BE
Journal: J Pharmacol Sci
The solution and solid state stability and excipient compatibility of parthenolide in feverfew.
Authors: Jin P, Madieh S, Augsburger LL
Journal: AAPS PharmSciTech
Parthenolide-depleted Feverfew (Tanacetum parthenium) protects skin from UV irradiation and external aggression.
Authors: Martin K, Sur R, Liebel F, Tierney N, Lyte P, Garay M, Oddos T, Anthonavage M, Shapiro S, Southall M
Journal: Arch Dermatol Res
Gene response of human monocytic cells for the detection of antimigraine activity of feverfew extracts.
Authors: Chen CF, Leung AY
Journal: Can J Physiol Pharmacol
Two cases of compositae dermatitis exacerbated by moisturizer containing feverfew.
Authors: Killoran CE, Crawford GH, Pedvis-Leftick A
Journal: Dermatitis
Parthenium dermatitis.
Authors: Sharma VK, Sethuraman G
Journal: Dermatitis
Trypanosoma cruzi: antiprotozoal activity of parthenolide obtained from Tanacetum parthenium (L.) Schultz Bip. (Asteraceae, Compositae) against epimastigote and amastigote forms.
Authors: Izumi E, Morello LG, Ueda-Nakamura T, Yamada-Ogatta SF, Filho BP, Cortez DA, Ferreira IC, Morgado-Díaz JA, Nakamura CV
Journal: Exp Parasitol
Antiapoptotic proteins as targets for bioactive compounds.
Authors: Pajak B
Journal: Pol J Vet Sci
Identification of antioxidant phenolic compounds in feverfew (Tanacetum parthenium) by HPLC-ESI-MS/MS and NMR.
Authors: Wu C, Chen F, Wang X, Wu Y, Dong M, He G, Galyean RD, He L, Huang G
Journal: Phytochem Anal
Antiproliferative activity of parthenolide against three human cancer cell lines and human umbilical vein endothelial cells.
Authors: Parada-Turska J, Paduch R, Majdan M, Kandefer-Szersze? M, Rzeski W
Journal: Pharmacol Rep
Parthenolide induces significant apoptosis and production of reactive oxygen species in high-risk pre-B leukemia cells.
Authors: Zunino SJ, Ducore JM, Storms DH
Journal: Cancer Lett
Analyzing factors that influence the folk use and phytonomy of 18 medicinal plants in Navarra.
Authors: Akerreta S, Cavero RY, López V, Calvo MI
Journal: J Ethnobiol Ethnomed
Quantitative estimation of parthenolide in Tanacetum parthenium (L.) Schultz-Bip. cultivated in Egypt.
Authors: El-Shamy AM, El-Hawary SS, Rateb ME
Journal: J AOAC Int
Compositae dermatitis from airborne parthenolide.
Authors: Paulsen E, Christensen LP, Andersen KE
Journal: Br J Dermatol
Tanacetum parthenium and Salix alba (Mig-RL) combination in migraine prophylaxis: a prospective, open-label study.
Authors: Shrivastava R, Pechadre JC, John GW
Journal: Clin Drug Investig
Are extraction methods in quantitative assays of pharmacopoeia monographs exhaustive? A comparison with pressurized liquid extraction.
Authors: Basalo C, Mohn T, Hamburger M
Journal: Planta Med
Quantification of parthenolide in Tanacetum species by LC-UV/LC-MS and microscopic comparison of Mexican/US feverfew samples.
Authors: Avula B, Navarrete A, Joshi VC, Khan IA
Journal: Pharmazie
A reproductive screening test of feverfew: is a full reproductive study warranted?
Authors: Yao M, Ritchie HE, Brown-Woodman PD
Journal: Reprod Toxicol
Parthenium dermatitis treated with azathioprine weekly pulse doses.
Authors: Srinivas CR
Journal: Indian J Dermatol Venereol Leprol
"Natural" or alternative medications for migraine prevention.
Authors: Evans RW, Taylor FR
Journal: Headache
Dereplication of pentacyclic triterpenoids in plants by GC-EI/MS.
Authors: Gu JQ, Wang Y, Franzblau SG, Montenegro G, Timmermann BN
Journal: Phytochem Anal
Feverfew for migraine prophylaxis.
Authors: Henneicke-von Zepelin HH
Journal: Headache
Antiproliferative activities of parthenolide and golden feverfew extract against three human cancer cell lines.
Authors: Wu C, Chen F, Rushing JW, Wang X, Kim HJ, Huang G, Haley-Zitlin V, He G
Journal: J Med Food
Parthenium dermatitis treated with azathioprine weekly pulse doses.
Authors: Verma KK, Bansal A, Sethuraman G
Journal: Indian J Dermatol Venereol Leprol
Treatment of rosacea with herbal ingredients.
Authors: Wu J
Journal: J Drugs Dermatol
Screening of plants used in Danish folk medicine to treat epilepsy and convulsions.
Authors: Jäger AK, Gauguin B, Adsersen A, Gudiksen L
Journal: J Ethnopharmacol
Efficacy and safety of 6.25 mg t.i.d. feverfew CO2-extract (MIG-99) in migraine prevention--a randomized, double-blind, multicentre, placebo-controlled study.
Authors: Diener HC, Pfaffenrath V, Schnitker J, Friede M, Henneicke-von Zepelin HH
Journal: Cephalalgia
Gelstat Migraine (sublingually administered feverfew and ginger compound) for acute treatment of migraine when administered during the mild pain phase.
Authors: Cady RK, Schreiber CP, Beach ME, Hart CC
Journal: Med Sci Monit
Feverfew: weeding out the root of leukaemia.
Authors: Guzman ML, Jordan CT
Journal: Expert Opin Biol Ther
Migraine and tension headache--a complementary and alternative medicine approach.
Authors: Woolhouse M
Journal: Aust Fam Physician
Parthenolide sensitizes ultraviolet (UV)-B-induced apoptosis via protein kinase C-dependent pathways.
Authors: Won YK, Ong CN, Shen HM
Journal: Carcinogenesis
Parthenolide is the component of tanacetum parthenium that inhibits nitroglycerin-induced Fos activation: studies in an animal model of migraine.
Authors: Tassorelli C, Greco R, Morazzoni P, Riva A, Sandrini G, Nappi G
Journal: Cephalalgia
Determination of aflatoxins in medicinal herbs by HPLC. An efficient method for routine analysis.
Authors: Gómez-Catalán J, Piqué E, Falcó G, Borrego N, Rodamilans M, Llobet JM
Journal: Phytochem Anal
Herbal medications commonly used in the practice of rheumatology: mechanisms of action, efficacy, and side effects.
Authors: Setty AR, Sigal LH
Journal: Semin Arthritis Rheum
Parthenolide and abscisic acid synthesis in feverfew are associated but environmental factors affect them dissimilarly.
Authors: Fonseca JM, Rushing JW, Rajapakse NC, Thomas RL, Riley MB
Journal: J Plant Physiol
Antileishmanial activity of parthenolide, a sesquiterpene lactone isolated from Tanacetum parthenium.
Authors: Tiuman TS, Ueda-Nakamura T, Garcia Cortez DA, Dias Filho BP, Morgado-Díaz JA, de Souza W, Nakamura CV
Journal: Antimicrob Agents Chemother
Feverfew for headaches.
Authors:
Journal: Consum Rep
Contact allergy to Compositae plants in patients with atopic dermatitis.
Authors: Jovanovi? M, Poljacki M, Duran V, Vujanovi? L, Sente R, Stojanovi? S
Journal: Med Pregl
Microtubule-interfering activity of parthenolide.
Authors: Miglietta A, Bozzo F, Gabriel L, Bocca C
Journal: Chem Biol Interact
A combination of riboflavin, magnesium, and feverfew for migraine prophylaxis: a randomized trial.
Authors: Maizels M, Blumenfeld A, Burchette R
Journal: Headache
Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction.
Authors: Unger M, Frank A
Journal: Rapid Commun Mass Spectrom
Biology of weed pollen allergens.
Authors: Gadermaier G, Dedic A, Obermeyer G, Frank S, Himly M, Ferreira F
Journal: Curr Allergy Asthma Rep
Evidenced-based use of botanicals, minerals, and vitamins in the prophylactic treatment of migraines.
Authors: Rios J, Passe MM
Journal: J Am Acad Nurse Pract
Involvement of proapoptotic Bcl-2 family members in parthenolide-induced mitochondrial dysfunction and apoptosis.
Authors: Zhang S, Ong CN, Shen HM
Journal: Cancer Lett
Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer.
Authors: Curry EA, Murry DJ, Yoder C, Fife K, Armstrong V, Nakshatri H, O'Connell M, Sweeney CJ
Journal: Invest New Drugs
In vitro behaviour of sesquiterpene lactones and sesquiterpene lactone-containing plant preparations in human blood, plasma and human serum albumin solutions.
Authors: Wagner S, Kratz F, Merfort I
Journal: Planta Med
Managing migraine in children.
Authors:
Journal: Drug Ther Bull
Feverfew for preventing migraine.
Authors: Pittler MH, Ernst E
Journal: Cochrane Database Syst Rev
Transport of parthenolide across human intestinal cells (Caco-2).
Authors: Khan SI, Abourashed EA, Khan IA, Walker LA
Journal: Planta Med
Commonly used herbs.
Authors: Cuddy ML
Journal: J Pract Nurs
Bioactive flavonoids of Tanacetum parthenium revisited.
Authors: Long C, Sauleau P, David B, Lavaud C, Cassabois V, Ausseil F, Massiot G
Journal: Phytochemistry
Modulation of lipopolysaccharide-induced proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin (chamomile), ginsenoside Rb(1) (ginseng) and parthenolide (feverfew).
Authors: Smolinski AT, Pestka JJ
Journal: Food Chem Toxicol
Herbal medicine.
Authors: Goadsby PJ
Journal: N Engl J Med
Migraine: preventive treatment.
Authors: Silberstein SD
Journal: Curr Med Res Opin
New medications show promise for migraine sufferers.
Authors:
Journal: Dent Today
The efficacy and safety of Tanacetum parthenium (feverfew) in migraine prophylaxis--a double-blind, multicentre, randomized placebo-controlled dose-response study.
Authors: Pfaffenrath V, Diener HC, Fischer M, Friede M, Henneicke-von Zepelin HH,
Journal: Cephalalgia
Do monoterpenes released from feverfew (Tanacetum parthenium) plants cause airborne Compositae dermatitis?
Authors: Paulsen E, Christensen LP, Andersen KE
Journal: Contact Dermatitis
Multi-component metabolic classification of commercial feverfew preparations via high-field 1H-NMR spectroscopy and chemometrics.
Authors: Bailey NJ, Sampson J, Hylands PJ, Nicholson JK, Holmes E
Journal: Planta Med
Variations in parthenolide content and daily dose of feverfew products.
Authors: Nelson MH, Cobb SE, Shelton J
Journal: Am J Health Syst Pharm
A herb for migraine.
Authors: Donaldson C
Journal: Nurs Times
Enhancement of 1 alpha,25-dihydroxyvitamin D(3)-induced differentiation of human leukaemia HL-60 cells into monocytes by parthenolide via inhibition of NF-kappa B activity.
Authors: Kang SN, Kim SH, Chung SW, Lee MH, Kim HJ, Kim TS
Journal: Br J Pharmacol
GC determination of parthenolide in feverfew products.
Authors: Abourashed EA, Khan IA
Journal: Pharmazie
5-Hydroxytryptamine-inhibiting property of Feverfew: role of parthenolide content.
Authors: Mittra S, Datta A, Singh SK, Singh A
Journal: Acta Pharmacol Sin
Comparative study of Tanacetum species growing in Bulgaria.
Authors: Todorova MN, Evstatieva LN
Journal: Z Naturforsch [C]
The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase.
Authors: Kwok BH, Koh B, Ndubuisi MI, Elofsson M, Crews CM
Journal: Chem Biol
Assessment of mutagenicity in Parthenium hysterophorus L.
Authors: Ramos A, Rivero R, Victoria MC, Visozo A, Piloto J, García A
Journal: J Ethnopharmacol
Pesticidal properties of parthenin (from Parthenium hysterophorus) and related compounds.
Authors: Datta S, Saxena DB
Journal: Pest Manag Sci
Feverfew extracts and the sesquiterpene lactone parthenolide inhibit intercellular adhesion molecule-1 expression in human synovial fibroblasts.
Authors: Piela-Smith TH, Liu X
Journal: Cell Immunol
Medicinal herbs: answers and advice, part 1.
Authors: Petry JJ, Hadley SK
Journal: Hosp Pract (Minneap)
Inhibition of interleukin-12 production in lipopolysaccharide-activated mouse macrophages by parthenolide, a predominant sesquiterpene lactone in Tanacetum parthenium: involvement of nuclear factor-kappaB.
Authors: Kang BY, Chung SW, Kim TS
Journal: Immunol Lett
The efficacy and safety of feverfew (Tanacetum parthenium L.): an update of a systematic review.
Authors: Ernst E, Pittler MH
Journal: Public Health Nutr
Exposure to Parthenium hysterophorous pollen extract leads to bronchospasm in stable patients of bronchial asthma.
Authors: Gupta D, Suresh PV, Behera D, Jindal SK
Journal: J Assoc Physicians India
Intra-specific variability of feverfew: correlations between parthenolide, morphological traits and seed origin.
Authors: Cutlan AR, Bonilla LE, Simon JE, Erwin JE
Journal: Planta Med
Determination of parthenolide in selected feverfew products by liquid chromatography.
Authors: Abourashed EA, Khan IA, Abourashed EA, Khan IA
Journal: J AOAC Int
Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide.
Authors: Patel NM, Nozaki S, Shortle NH, Bhat-Nakshatri P, Newton TR, Rice S, Gelfanov V, Boswell SH, Goulet RJ, Sledge GW, Nakshatri H
Journal: Oncogene
Feverfew for preventing migraine.
Authors: Pittler MH, Vogler BK, Ernst E
Journal: Cochrane Database Syst Rev
Inhibition by parthenolide of phorbol ester-induced transcriptional activation of inducible nitric oxide synthase gene in a human monocyte cell line THP-1.
Authors: Fukuda K, Hibiya Y, Mutoh M, Ohno Y, Yamashita K, Akao S, Fujiwara H
Journal: Biochem Pharmacol
Prurigo-nodularis-like lesion in parthenium dermatitis.
Authors: Sharma VK, Sahoo B
Journal: Contact Dermatitis
Azathioprine as a corticosteroid sparing agent for the treatment of dermatitis caused by the weed Parthenium.
Authors: Verma KK, Manchanda Y, Pasricha JS
Journal: Acta Derm Venereol
[Feverfew as a prophylactic treatment of migraine]
Authors: Prusi?ski A, Durko A, Niczyporuk-Turek A
Journal: Neurol Neurochir Pol
Antinociceptive and anti-inflammatory effects of Tanacetum parthenium L. extract in mice and rats.
Authors: Jain NK, Kulkarni SK
Journal: J Ethnopharmacol
Rapid extraction and high-performance liquid chromatographic determination of parthenolide in feverfew (Tanacetum parthenium).
Authors: Zhou JZ, Kou X, Stevenson D
Journal: J Agric Food Chem
T-lymphocyte cytokine profiles in compositae airborne dermatitis.
Authors: Stingeni L, Agea E, Lisi P, Spinozzi F
Journal: Br J Dermatol
Cranberry, feverfew, horse chestnut, and kava.
Authors: Rotblatt MD
Journal: West J Med
Airborne Compositae dermatitis: monoterpenes and no parthenolide are released from flowering Tanacetum parthenium (feverfew) plants.
Authors: Christensen LP, Jakobsen HB, Paulsen E, Hodal L, Andersen KE
Journal: Arch Dermatol Res
The flavonoids of Tanacetum parthenium and T. vulgare and their anti-inflammatory properties.
Authors: Williams CA, Harborne JB, Geiger H, Hoult JR
Journal: Phytochemistry
Low concentrations of the feverfew component parthenolide inhibit in vitro growth of tumor lines in a cytostatic fashion.
Authors: Ross JJ, Arnason JT, Birnboim HC
Journal: Planta Med
Feverfew as a preventive treatment for migraine: a systematic review.
Authors: Vogler BK, Pittler MH, Ernst E
Journal: Cephalalgia
Is feverfew a pharmacologic agent?
Authors: Wong HC
Journal: CMAJ
A review of 12 commonly used medicinal herbs.
Authors: O'Hara M, Kiefer D, Farrell K, Kemper K
Journal: Arch Fam Med
Anti-inflammatory effects of South American Tanacetum vulgare.
Authors: Schinella GR, Giner RM, Recio MC, Mordujovich de Buschiazzo P, Ríos JL, Máñez S
Journal: J Pharm Pharmacol
Chemical composition and antimicrobial activity of Tanacetum parthenium essential oil.
Authors: Kalodera Z, Pepeljnjak S, Blazevi? N, Petrak T
Journal: Pharmazie
Melatonin in feverfew and other medicinal plants.
Authors: Murch SJ, Simmons CB, Saxena PK
Journal: Lancet
The content of parthenolide and its yield per plant during the growth of Tanacetum parthenium.
Authors: Hendricks H, Anderson-Wildeboer Y, Engels G, Bos R, Woerdenbag HJ
Journal: Planta Med
Pharmacological activity of feverfew (Tanacetum parthenium (L.) Schultz-Bip.): assessment by inhibition of human polymorphonuclear leukocyte chemiluminescence in-vitro.
Authors: Brown AM, Edwards CM, Davey MR, Power JB, Lowe KC
Journal: J Pharm Pharmacol
The antimicrobial activity of Tanacetum parthenium extract.
Authors: Kalodera Z, Pepeljnjak S, Petrak T
Journal: Pharmazie
Inhibition of the expression of inducible cyclooxygenase and proinflammatory cytokines by sesquiterpene lactones in macrophages correlates with the inhibition of MAP kinases.
Authors: Hwang D, Fischer NH, Jang BC, Tak H, Kim JK, Lee W
Journal: Biochem Biophys Res Commun
Esoteric contact dermatitis. Part IV: Devastating contact dermatitis in India produced by American parthenium weed (the scourge of India).
Authors: Fisher AA
Journal: Cutis
Parthenolide inhibits the contractile responses of rat stomach fundus to fenfluramine and dextroamphetamine but not serotonin.
Authors: Béjar E
Journal: J Ethnopharmacol
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