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psoriasis		A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis. [ Articles | Books | Images | Discussion groups ]
Additional comments : (Palmoplantaris Pustulosis, Pustular Psoriasis of Palms and Soles) Psoriasis is an inflammatory skin disease that affects 2% of the population. It is characterised by red, scaly skin patches which are usually found on the scalp, elbows and knees, and may be associated with severe arthropathy. The lesions are caused by abnormal keratinocyte proliferation, and infiltration of inflammatory cells into the dermis and epidermis. The usual age of onset of psoriasis is between 15 and 30 years, although it can present at any age. Psoriasis is recognised to have a large genetic component. Matthews D, Fry L, Powles A, Weber J, McCarthy M, Fisher E, Davies K, Williamson R. Nat Genet. 1996 Oct;14(2):231-3. Psoriasis is a common and persistent papulosquamous disease of unknown etiology, which affects up to 2% of the population ( Krueger et al. 1984). Psoriasis is a genetically inherited spectrum of skin diseases characterized by epidermal proliferation and inflammation, which are reversible. GG Krueger, M Duvic - Journal of Investigative Dermatology, 1994 Psoriasis is a chronic skin disorder characterized by keratinocyte hyperproliferation, angiogenesis and inflammatory leukocyte infiltrates. K Asumalahti, T Laitinen, R Itkonen-Vatjus, ML … - Human Molecular Genetics, 2000 Psoriasis is a common papulosquamous skin disease. The histopathology is characterized by epidermal hyperplasia and inflammation. Recent studies suggest that keratinocyte proliferation and inflammation in psoriasis are manifestations of the same underlying pathological process. Grossman RM, Krueger J, Yourish D, Granelli-Piperno A, Murphy DP, May LT, Kupper TS, Sehgal PB, Gottlieb AB.

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