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hypertonic saline solution Hypertonic sodium chloride solution. A solution having an osmotic pressure greater than that of physiologic salt solution (0.9 g NaCl in 100 ml purified water).


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PubmedVasal irrigation with sterile water and saline solution for acceleration of postvasectomy azoospermia.
Authors:  Roshani A, Falahatkar S, Khosropanah I, Golbaghi MR, Kiani SA, Akbarpour M
Journal: Urol J

PubmedHypertonic saline after traumatic brain injury in UK neuro-critical care practice.
Authors:  Wenham TN, Hormis AP, Andrzejowski JC
Journal: Anaesthesia

PubmedResuscitation of hypotensive head-injured patients: is hypertonic saline the answer?
Authors:  Pascual JL, Maloney-Wilensky E, Reilly PM, Sicoutris C, Keutmann MK, Stein SC, LeRoux PD, Gracias VH
Journal: Am Surg

PubmedChemical castration with intratesticular injection of 20% hypertonic saline: A minimally invasive method.
Authors:  Emir L, Dadal? M, Sunay M, Erol D, Caydere M, U?stün H
Journal: Urol Oncol

PubmedComparison of induced sputum and bronchoalveolar lavage fluid cell profile during the treatment of pulmonary sarcoidosis.
Authors:  Mroz RM, Korniluk M, Stasiak-Barmuta A, Chyczewska E
Journal: J Physiol Pharmacol

PubmedExperimental jaw-muscle pain has a differential effect on different jaw movement tasks.
Authors:  Sae-Lee D, Whittle T, Peck CC, Forte AR, Klineberg IJ, Murray GM
Journal: J Orofac Pain

PubmedLess impairment of hemostasis and reduced blood loss in pigs after resuscitation from hemorrhagic shock using the small-volume concept with hypertonic saline/hydroxyethyl starch as compared to administration of 4% gelatin or 6% hydroxyethyl starch solution.
Authors:  Haas T, Fries D, Holz C, Innerhofer P, Streif W, Klingler A, Hanke A, Velik-Salchner C
Journal: Anesth Analg

PubmedMore evidence supporting a "brain code" protocol for reversal of transtentorial herniation.
Authors:  Qureshi AI, Suarez JI
Journal: Neurology

Pubmed[Orbital hydatid cyst.]
Authors:  Jeblaoui Y, Bouguila J, Yacoub K, Bouguila H, Ben Neji N, Besbes G
Journal: Rev Stomatol Chir Maxillofac

PubmedHypertonic saline.
Authors:  Bergui M, Bradac GB
Journal: J Neurosurg

Pubmed[Effect of cationic and anionic amphiphilic compounds on hypertonic cryohemolysis of mammalian red blood cells]
Authors:  Iershov SS, Pysarenko NA, Orlova NV, Shpakova NM
Journal: Fiziol Zh

PubmedInfusion of hypertonic saline before elective hysterectomy: effects on cytokines and stress hormones.
Authors:  Kolsen-Petersen JA, Bendtzen K, Tonnesen E
Journal: Br J Anaesth

PubmedEffects of resuscitation fluid on neurologic physiology after cerebral trauma and hemorrhage.
Authors:  Baker AJ, Park E, Hare GM, Liu E, Sikich N, Mazer DC
Journal: J Trauma

PubmedOsmotic demyelination syndrome associated with 3% hypertonic saline administration.
Authors:  Wang AH
Journal: Intern Med J

PubmedClinical efficacy of intravenous hypertonic saline solution or hypertonic bicarbonate solution in the treatment of inappetent calves with neonatal diarrhea.
Authors:  Koch A, Kaske M
Journal: J Vet Intern Med

PubmedVolume and electrolyte management.
Authors:  Tommasino C, Picozzi V
Journal: Best Pract Res Clin Anaesthesiol

PubmedHypertonic resuscitation of hypovolemic shock after blunt trauma: a randomized controlled trial.
Authors:  Bulger EM, Jurkovich GJ, Nathens AB, Copass MK, Hanson S, Cooper C, Liu PY, Neff M, Awan AB, Warner K, Maier RV
Journal: Arch Surg

PubmedReversal of transtentorial herniation with hypertonic saline.
Authors:  Koenig MA, Bryan M, Lewin JL, Mirski MA, Geocadin RG, Stevens RD
Journal: Neurology

PubmedThe effect of 7.2% hypertonic saline solution with 6% dextran 70 on cardiac contractility as observed by an echocardiography in normovolemic and anesthetized dogs.
Authors:  Suzuki K, Otake M, Saida Y, Koie H, Asano R
Journal: J Vet Med Sci

PubmedHyperosmolarity-induced cornification of human corneal epithelial cells is regulated by JNK MAPK.
Authors:  Chen Z, Tong L, Li Z, Yoon KC, Qi H, Farley W, Li DQ, Pflugfelder SC
Journal: Invest Ophthalmol Vis Sci

PubmedHypertonic resuscitation: design and implementation of a prehospital intervention trial.
Authors:  Brasel KJ, Bulger E, Cook AJ, Morrison LJ, Newgard CD, Tisherman SA, Kerby JD, Coimbra R, Hata JS, Hoyt DB,  
Journal: J Am Coll Surg

PubmedUltra-early hyperosmolar treatment in traumatic brain injury: will surgery soon be old-school?
Authors:  Froelich M, Härtl R
Journal: Crit Care Med

PubmedCerebral salt wasting versus SIADH: what difference?
Authors:  Sterns RH, Silver SM
Journal: J Am Soc Nephrol

PubmedEquimolar doses of mannitol and hypertonic saline in the treatment of increased intracranial pressure.
Authors:  Francony G, Fauvage B, Falcon D, Canet C, Dilou H, Lavagne P, Jacquot C, Payen JF
Journal: Crit Care Med

PubmedEffects of small- and large-volume resuscitation on coagulation and electrolytes during experimental endotoxemia in anesthetized horses.
Authors:  Pantaleon LG, Furr MO, McKenzie HC, Donaldson L
Journal: J Vet Intern Med

PubmedReply to: "Amitriptyline-induced Brugada pattern fails to respond to sodium bicarbonate".
Authors:  Bebarta VS, Waksman JC
Journal: Clin Toxicol (Phila)

PubmedEffects of hypertonic/hyperoncotic treatment and surgical evacuation after acute subdural hematoma in rats.
Authors:  Jussen D, Papaioannou C, Heimann A, Kempski O, Alessandri B
Journal: Crit Care Med

PubmedEffect of hypertonic saline concentration on cerebral and visceral organ water in an uninjured rodent model.
Authors:  Toung TJ, Nyquist P, Mirski MA
Journal: Crit Care Med

PubmedSpecies distribution and physiological characterization of Acinetobacter genospecies from healthy human skin of tribal population in India.
Authors:  Yavankar SP, Pardesi KR, Chopade BA
Journal: Indian J Med Microbiol

PubmedCommon toads (Bufo arenarum) learn to anticipate and avoid hypertonic saline solutions.
Authors:  Daneri MF, Papini MR, Muzio RN
Journal: J Comp Psychol

PubmedExhaled nitric oxide for monitoring childhood asthma inflammation compared to sputum analysis, serum interleukins and pulmonary function.
Authors:  Paro-Heitor ML, Bussamra MH, Saraiva-Romanholo BM, Martins MA, Okay TS, Rodrigues JC
Journal: Pediatr Pulmonol

PubmedSilicone Foley catheters outperform latex Foley catheters for post-nasal packing: an in-vitro study.
Authors:  Almeyda R, Shahzad A, Bleach N
Journal: Clin Otolaryngol

PubmedEffect of equiosmolar solutions of mannitol versus hypertonic saline on intraoperative brain relaxation and electrolyte balance.
Authors:  Rozet I, Tontisirin N, Muangman S, Vavilala MS, Souter MJ, Lee LA, Kincaid MS, Britz GW, Lam AM
Journal: Anesthesiology

PubmedHypertonic saline for craniotomy?
Authors:  McDonagh DL, Warner DS
Journal: Anesthesiology

PubmedEndoscopic injection therapy for post-sphincterotomy bleeding: single injection orad to the papilla versus double injection orad to and into the papilla.
Authors:  Matsushita M, Uchida K, Okazaki K
Journal: Endoscopy

PubmedComparison of CT-guided sclerotherapy with using 95% ethanol and 20% hypertonic saline for managing simple renal cyst.
Authors:  Egilmez H, Gok V, Oztoprak I, Atalar M, Cetin A, Arslan M, Gultekin Y, Solak O
Journal: Korean J Radiol

PubmedA pinch of salt for convulsive status epilepticus.
Authors:  Hoption Cann SA
Journal: Lancet

PubmedA randomized comparison of misoprostol to intrauterine instillation of hypertonic saline plus a prostaglandin F2alpha analogue for second-trimester induction termination in Uzbekistan.
Authors:  Kapp N, Todd CS, Yadgarova KT, Alibayeva G, Nazarova D, Loza O, Babadjanova GS
Journal: Contraception

PubmedAcute bronchiolitis. There may be a treatment.
Authors:  Thiessen PN
Journal: BMJ

PubmedEffect of hydroxyethyl starch solution in normal horses and horses with colic or acute colitis.
Authors:  Schusser GF, Rieckhoff K, Ungemach FR, Huskamp NH, Scheidemann W
Journal: J Vet Med A Physiol Pathol Clin Med

PubmedThe pain-induced decrease in low-threshold motor unit discharge rate is not associated with the amount of increase in spike-triggered average torque.
Authors:  Farina D, Arendt-Nielsen L, Roatta S, Graven-Nielsen T
Journal: Clin Neurophysiol

PubmedSerotonergic receptor blockade in the lateral parabrachial nucleus: different effects on hypertonic and isotonic NaCl intake.
Authors:  David RB, Menani JV, De Luca LA
Journal: Brain Res

Pubmedbeta-Endorphin in the median preoptic nucleus modulates the pressor response induced by subcutaneous hypertonic sodium chloride.
Authors:  Ximena C, Laura V
Journal: Exp Neurol

PubmedResuscitation from hemorrhagic shock comparing standard hemoglobin-based oxygen carrier (HBOC)-201 versus 7.5% hypertonic HBOC-201.
Authors:  Rivera-Chavez FA, Huerta S, Brown R, York GB, Minei JP
Journal: J Trauma

PubmedHypertonic saline solution for renal failure prevention in patients with decompensated heart failure.
Authors:  Issa VS, Bacal F, Mangini S, Carneiro RM, Azevedo CH, Chizzola PR, Ferreira SM, Bocchi EA
Journal: Arq Bras Cardiol

PubmedOsmotic cell shrinkage activates ezrin/radixin/moesin (ERM) proteins: activation mechanisms and physiological implications.
Authors:  Rasmussen M, Alexander RT, Darborg BV, Mřbjerg N, Hoffmann EK, Kapus A, Pedersen SF
Journal: Am J Physiol Cell Physiol

PubmedPercutaneous treatment of hepatic hydatid cyst in pregnancy: long-term results.
Authors:  Ustunsoz B, Ugurel MS, Uzar AI, Duru NK
Journal: Arch Gynecol Obstet

PubmedA novel technique for wound irrigation.
Authors:  Ahmad R, Ahmed SM, Radford M
Journal: Ann R Coll Surg Engl

PubmedThe effect of saline solutions on nasal patency and mucociliary clearance in rhinosinusitis patients.
Authors:  Hauptman G, Ryan MW
Journal: Otolaryngol Head Neck Surg

PubmedEndoscopic management of duodenal diverticular bleeding.
Authors:  Onozato Y, Kakizaki S, Ishihara H, Iizuka H, Sohara N, Okamura S, Mori M, Itoh H
Journal: Gastrointest Endosc

PubmedIntravitreal injections of GDNF-loaded biodegradable microspheres are neuroprotective in a rat model of glaucoma.
Authors:  Jiang C, Moore MJ, Zhang X, Klassen H, Langer R, Young M
Journal: Mol Vis

Pubmed[Prevention of perioperative hyperchloremic acidosis]
Authors:  González Suárez S
Journal: Rev Esp Anestesiol Reanim

PubmedEosinophilic airway inflammation and the prognosis of childhood asthma.
Authors:  Lovett CJ, Whitehead BF, Gibson PG
Journal: Clin Exp Allergy

PubmedThe Adrogue-Madias formula revisited.
Authors:  Berl T
Journal: Clin J Am Soc Nephrol

PubmedVariations of p38 MAPK and sICAM-1 with therapeutic effect of different resuscitation fluids on severe traumatic patients.
Authors:  Bing M, Zheng-lu H, Hui C, Xian D, Jian H
Journal: Chin J Traumatol

PubmedProperties of the major classes of mechanoreceptors in the guinea pig bladder.
Authors:  Zagorodnyuk VP, Gibbins IL, Costa M, Brookes SJ, Gregory SJ
Journal: J Physiol

PubmedHypertonic saline for hyponatremia: risk of inadvertent overcorrection.
Authors:  Mohmand HK, Issa D, Ahmad Z, Cappuccio JD, Kouides RW, Sterns RH
Journal: Clin J Am Soc Nephrol

PubmedValidity and reproducibility of morphologic analysis of nasal secretions obtained using ultrasonic nebulization of hypertonic solution.
Authors:  Ventura MT, Toungoussova O, Barbaro MP, Resta O, Carpagnano GE, Dragonieri S, Migliori GB, Neri M, Spanevello A
Journal: Ann Allergy Asthma Immunol

PubmedPharmacotherapy of impaired mucociliary clearance in non-CF pediatric lung disease. A review of the literature.
Authors:  Boogaard R, de Jongste JC, Merkus PJ
Journal: Pediatr Pulmonol

PubmedOrganum vasculosum laminae terminalis contributes to increased sympathetic nerve activity induced by central hyperosmolality.
Authors:  Shi P, Stocker SD, Toney GM
Journal: Am J Physiol Regul Integr Comp Physiol

PubmedHypertonic saline solutions for treatment of intracranial hypertension.
Authors:  Himmelseher S
Journal: Curr Opin Anaesthesiol

PubmedHypertonic saline solution stimulated CLC-3 production in primary cultured human nasal epithelial cells.
Authors:  Li HB, Shi JB, Cao F, Cheng L, Wen WP, Xu G
Journal: Auris Nasus Larynx

PubmedIn-vitro renal shrinkage after hypertonic saline perfusion for organ removal during laparoscopic nephrectomy.
Authors:  Andreoni C, Araujo MB, Bomfim AC, Manzano JP, Silva FD, Scapulatempo-Neto C, Fagundes DJ, Poli-de-Figueiredo L, Ortiz V
Journal: J Endourol

PubmedMarinobacter segnicrescens sp. nov., a moderate halophile isolated from benthic sediment of the South China Sea.
Authors:  Guo B, Gu J, Ye YG, Tang YQ, Kida K, Wu XL
Journal: Int J Syst Evol Microbiol

PubmedThe influence of volume management on outcome.
Authors:  Bagshaw SM, Bellomo R
Journal: Curr Opin Crit Care

Pubmed[Severe hyponatremia with pulmonary and cerebral edema in an Ironman triathlete]
Authors:  Richter S, Betz C, Geiger H
Journal: Dtsch Med Wochenschr

Pubmed[Carbamazepine-induced hyponatremia]
Authors:  Krysiak R, Okopie? B
Journal: Pol Arch Med Wewn

PubmedNebulized hypertonic saline in the treatment of viral bronchiolitis in infants.
Authors:  Kuzik BA, Al-Qadhi SA, Kent S, Flavin MP, Hopman W, Hotte S, Gander S
Journal: J Pediatr

PubmedAcute viral bronchiolitis: to treat or not to treat-that is the question.
Authors:  Calogero C, Sly PD
Journal: J Pediatr

PubmedTRPV1-mediated diuresis and natriuresis induced by hypertonic saline perfusion of the renal pelvis.
Authors:  Zhu Y, Xie C, Wang DH
Journal: Am J Nephrol

PubmedDifferences in osmotolerant and cell-wall properties of two Zygosaccharomyces rouxii strains.
Authors:  Pribylová L, Farkas V, Slaninová I, de Montigny J, Sychrová H
Journal: Folia Microbiol (Praha)

PubmedMutation of a gene encoding a putative ribokinase leads to reduced salt tolerance under potassium limitation in Bacillus subtilis.
Authors:  Ulanova D, Holanová V, Prenosilová L, Náprstek J, Lichá I
Journal: Folia Microbiol (Praha)

PubmedA novel method using fluorescence microscopy for real-time assessment of ATP release from individual cells.
Authors:  Corriden R, Insel PA, Junger WG
Journal: Am J Physiol Cell Physiol

PubmedEnhancement of cerebral blood flow using systemic hypertonic saline therapy improves outcome in patients with poor-grade spontaneous subarachnoid hemorrhage.
Authors:  Tseng MY, Al-Rawi PG, Czosnyka M, Hutchinson PJ, Richards H, Pickard JD, Kirkpatrick PJ
Journal: J Neurosurg

PubmedUse of nuclear magnetic resonance spectroscopy to assess renal dysfunction after hypertonic-hyperoncotic resuscitation in rats.
Authors:  Amathieu R, Racine S, Triba M, Poloujadoff MP, Borron SW, Bouchemal N, Lapostolle F, Merouani M, Le Moyec L, Adnet F
Journal: J Trauma

PubmedThe effects of a novel resuscitation strategy combining pentoxifylline and hypertonic saline on neutrophil MAPK signaling.
Authors:  Deree J, Melbostad H, Loomis WH, Putnam JG, Coimbra R
Journal: Surgery

PubmedEndotoxin removal from albumin and saline solutions.
Authors:  Bell CM, Guo K, Wendel HP
Journal: Int J Artif Organs

PubmedThe effect of hypertonic saline solution on vasodilatation of the superior sagittal sinus using magnetic resonance imaging in normovolemic dogs.
Authors:  Suzuki K, Koie H, Matsumoto T, Asano R
Journal: Res Vet Sci

PubmedA case report of syndrome of inappropriate secretion of antidiuretic hormone with marked edema due to administration of hypertonic saline.
Authors:  Maeda H, Tsuruya K, Yotsueda H, Taniguchi M, Tokumoto M, Hirakata H, Iida M
Journal: Ther Apher Dial

PubmedEffect of osmotherapy with hypertonic saline on regional cerebral edema following experimental stroke: a study utilizing magnetic resonance imaging.
Authors:  Chen CH, Xue R, Zhang J, Li X, Mori S, Bhardwaj A
Journal: Neurocrit Care

PubmedInfluence of plasma osmolality on baroreflex control of sympathetic activity.
Authors:  Wenner MM, Rose WC, Delaney EP, Stillabower ME, Farquhar WB
Journal: Am J Physiol Heart Circ Physiol

PubmedIntravenous hypertonic NaCl acts via cerebral sodium-sensitive and angiotensinergic mechanisms to improve cardiac function in haemorrhaged conscious sheep.
Authors:  Frithiof R, Eriksson S, Bayard F, Svensson T, Rundgren M
Journal: J Physiol

PubmedNasal saline irrigations for the symptoms of chronic rhinosinusitis.
Authors:  Harvey R, Hannan SA, Badia L, Scadding G
Journal: Cochrane Database Syst Rev

Pubmed[Hypotonic swelling activates the Na*/H* exchange in rat brain synaptosomes]
Authors:  Kolos VA, Vasim TV, Fedorovich SV
Journal: Biofizika

PubmedEnhancement of meal-associated hypertonic NaCl intake by moxonidine into the lateral parabrachial nucleus.
Authors:  Andrade CA, De Luca LA, Colombari DS, Menani JV
Journal: Behav Brain Res

PubmedPelagibacillus goriensis gen. nov., sp. nov., a moderately halotolerant bacterium isolated from coastal water off the east coast of Korea.
Authors:  Kim YG, Hwang CY, Yoo KW, Moon HT, Yoon JH, Cho BC
Journal: Int J Syst Evol Microbiol

PubmedA case of persistent hyponatraemia due to reset osmostat.
Authors:  Rohana AG, Norasyikin AW, Suehazlyn Z, Ming W, Norlela S, Norazmi MK
Journal: Med J Malaysia

PubmedRegulation of NaCl solution intake and gastric emptying in adrenalectomized rats.
Authors:  Bykowski MR, Smith JC, Stricker EM
Journal: Physiol Behav

PubmedFibromyalgia patients show an abnormal dopamine response to pain.
Authors:  Wood PB, Schweinhardt P, Jaeger E, Dagher A, Hakyemez H, Rabiner EA, Bushnell MC, Chizh BA
Journal: Eur J Neurosci

PubmedPeptidomic identification and biological validation of neuroendocrine regulatory peptide-1 and -2.
Authors:  Yamaguchi H, Sasaki K, Satomi Y, Shimbara T, Kageyama H, Mondal MS, Toshinai K, Date Y, González LJ, Shioda S, Takao T, Nakazato M, Minamino N
Journal: J Biol Chem

Pubmed[Comparison of sensitivity and specifity of two bronchial provocation tests with methacholine and hypertonic saline in bronchial hyperreactivity evaluation in asthmatics]
Authors:  Piotrowska T, Siergiejko G, Siergiejko Z
Journal: Pol Merkur Lekarski

PubmedEvolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans.
Authors:  Choe KP, Strange K
Journal: Am J Physiol Cell Physiol

PubmedQuality of life in children with undiagnosed and diagnosed asthma.
Authors:  van Gent R, van Essen LE, Rovers MM, Kimpen JL, van der Ent CK, de Meer G
Journal: Eur J Pediatr

PubmedPleural fluid exchange in rabbits.
Authors:  Stashenko GJ, Robichaux A, Lee YC, Sanders JR, Roselli RJ, Light RW
Journal: Respirology

PubmedHypertonic saline: first-line therapy for cerebral edema?
Authors:  Ziai WC, Toung TJ, Bhardwaj A
Journal: J Neurol Sci

PubmedThe effects of normal and hypertonic saline on regional blood flow and oxygen delivery.
Authors:  Wan L, Bellomo R, May CN
Journal: Anesth Analg

PubmedHypertonic saline: a clinical review.
Authors:  Tyagi R, Donaldson K, Loftus CM, Jallo J
Journal: Neurosurg Rev

PubmedInadvertent hyponatremia leading to acute cerebral edema and early evidence of herniation.
Authors:  Carpenter J, Weinstein S, Myseros J, Vezina G, Bell MJ
Journal: Neurocrit Care

PubmedCentrally administered vasopressin cross-sensitizes rats to amphetamine and drinking hypertonic NaCl.
Authors:  McBride SM, Flynn FW
Journal: Am J Physiol Regul Integr Comp Physiol

PubmedRationale for hypertonic saline therapy for cystic fibrosis lung disease.
Authors:  Tarran R, Donaldson S, Boucher RC
Journal: Semin Respir Crit Care Med





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