flecainide - Medical Dictionary

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flecainide		A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial arrhythmias and tachycardias. Paradoxically, however, in myocardial infarct patients with either symptomatic or asymptomatic arrhythmia, flecainide exacerbates the arrhythmia and is not recommended for use in these patients. [ Books \| Images \| Discussion groups ]

Additional comments : (Flecainide Acetate, Apocard, Flecadura, Flecatab, Tambocor) Articles The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome. Authors: Makita N, Behr E, Shimizu W, Horie M, Sunami A, Crotti L, Schulze-Bahr E, Fukuhara S, Mochizuki N, Makiyama T, Itoh H, Christiansen M, McKeown P, Miyamoto K, Kamakura S, Tsutsui H, Schwartz PJ, George AL, Roden DM Journal: J Clin Invest Treatment of new-onset atrial fibrillation in noncardiac intensive care unit patients: a systematic review of randomized controlled trials. Authors: Kanji S, Stewart R, Fergusson DA, McIntyre L, Turgeon AF, Hébert PC Journal: Crit Care Med Pharmacological therapy in children with nodal reentry tachycardia: when, how and how long to treat the affected patients. Authors: Bouhouch R, El Houari T, Fellat I, Arharbi M Journal: Curr Pharm Des Pharmacological therapy in children with atrioventricular reentry: which drug? Authors: Ratnasamy C, Rossique-Gonzalez M, Young ML Journal: Curr Pharm Des Induced Brugada-type electrocardiogram, a sign for imminent malignant arrhythmias. Authors: Junttila MJ, Gonzalez M, Lizotte E, Benito B, Vernooy K, Sarkozy A, Huikuri HV, Brugada P, Brugada J, Brugada R Journal: Circulation Paroxysmal reciprocating supraventricular tachycardia in infants: electrophysiologically guided medical treatment and long-term evolution of the re-entry circuit. Authors: Drago F, Silvetti MS, De Santis A, Marcora S, Fazio G, Anaclerio S, Versacci P, Iodice F, Di Ciommo V Journal: Europace Verapamil-sensitive ventricular tachycardia in an infant. Authors: Snyder C, Bishara J, Darling R, Lucas V Journal: Congenit Heart Dis Paranoid Psychosis and Myoclonus: Flecainide Toxicity in Renal Failure. Authors: Ting SM, Lee D, Maclean D, Sheerin NS Journal: Cardiology Flecainide: Safety and Efficacy. Authors: Somberg JC Journal: Cardiology Effect of drugs on defibrillation capacity. Authors: Dopp AL, Miller JM, Tisdale JE Journal: Drugs Spontaneous alternans in Brugada ST-segment morphology within minutes. Authors: Ariyarajah V, Smith H, Hodge S, Khadem A Journal: J Electrocardiol [Clinical case of the month. Atrial flutter with rapid ventricular response (1:1 atrioventricular conduction) caused by flecaïnide] Authors: Robinet S, Melon R, Piérard L Journal: Rev Med Liege [Drug-related neuropathies: Analysis of the French Adverse Drug Reaction Database 1995-2005.] Authors: Durrieu G, Lacroix I, Olivier P, Sommet A, Sénard JM, Montastruc JL, Journal: Presse Med The challenge of fetal dysrhythmias: echocardiographic diagnosis and clinical management. Authors: D'Alto M, Russo MG, Paladini D, Di Salvo G, Romeo E, Ricci C, Felicetti M, Tartaglione A, Cardaropoli D, Pacileo G, Sarubbi B, Calabrò R Journal: J Cardiovasc Med (Hagerstown) A case of Commotio cordis in a young child caused by a fall. Authors: Tibballs J, Thiruchelvam T Journal: Resuscitation Neonatal rat cardiac fibroblasts express three types of voltage-gated K+ channels: regulation of a transient outward current by protein kinase C. Authors: Walsh KB, Zhang J Journal: Am J Physiol Heart Circ Physiol A randomized comparison of amiodarone and class IC antiarrhythmic drugs to treat atrial fibrillation in patients paced for sinus node disease: the Prevention Investigation and Treatment: A Group for Observation and Research on Atrial arrhythmias (PITAGORA) trial. Authors: Gulizia M, Mangiameli S, Orazi S, Chiarandà G, Piccione G, Di Giovanni N, Colletti A, Pensabene O, Lisi F, Vasquez L, Grammatico A, Boriani G, Journal: Am Heart J Flecainide for the treatment of chronic neuropathic pain: a Phase II trial. Authors: von Gunten CF, Eappen S, Cleary JF, Taylor SG, Moots P, Regevik N, Cleeland C, Cella D Journal: Palliat Med The cardiac persistent sodium current: an appealing therapeutic target? Authors: Saint DA Journal: Br J Pharmacol [New strategies in the treatment of atrial fibrillation] Authors: Tamargo Menéndez J Journal: An R Acad Nac Med (Madr) A novel and lethal de novo LQT-3 mutation in a newborn with distinct molecular pharmacology and therapeutic response. Authors: Bankston JR, Yue M, Chung W, Spyres M, Pass RH, Silver E, Sampson KJ, Kass RS Journal: PLoS ONE Mechanisms underlying increased right ventricular conduction sensitivity to flecainide challenge. Authors: Veeraraghavan R, Poelzing S Journal: Cardiovasc Res Different effects of antiarrhythmic drugs on the rate-dependency of QT interval: a study with amiodarone and flecainide. Authors: Malfatto G, Zaza A, Facchini M Journal: J Cardiovasc Pharmacol ECG findings in fatal flecainide intoxication. Authors: Airaksinen KE, Koistinen MJ Journal: Heart Choice of cardiac tissue in vitro plays an important role in assessing the risk of drug-induced cardiac arrhythmias in human: Beyond QT prolongation. Authors: Lu HR, Vlaminckx E, Gallacher DJ Journal: J Pharmacol Toxicol Methods Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation. Authors: Lafuente-Lafuente C, Mouly S, Longas-Tejero MA, Bergmann JF Journal: Cochrane Database Syst Rev Treatment of chronic atrial fibrillation in the horse with flecainide: personal observation. Authors: Birettoni F, Porciello F, Rishniw M, della Rocca G, Di Salvo A, Sgorbini M Journal: Vet Res Commun [Brugada syndrome and work place: two case report] Authors: Martini A, Signorini S, Jannone V, Riservato R, Fantini S Journal: G Ital Med Lav Ergon The molecular basis of high-affinity binding of the antiarrhythmic compound vernakalant (RSD1235) to Kv1.5 channels. Authors: Eldstrom J, Wang Z, Xu H, Pourrier M, Ezrin A, Gibson K, Fedida D Journal: Mol Pharmacol Criteria for arrhythmogenicity in genetically-modified Langendorff-perfused murine hearts modelling the congenital long QT syndrome type 3 and the Brugada syndrome. Authors: Sabir IN, Li LM, Jones VJ, Goddard CA, Grace AA, Huang CL Journal: Pflugers Arch Simultaneous separation of 14 antiarrhythmic drugs and determination of mexiletine and flecainide by capillary zone electrophoresis. Authors: Pietra? R, Kowalczuk D, Hopka?a H Journal: J AOAC Int Novel mutation in the SCN5A gene associated with arrhythmic storm development during acute myocardial infarction. Authors: Hu D, Viskin S, Oliva A, Carrier T, Cordeiro JM, Barajas-Martinez H, Wu Y, Burashnikov E, Sicouri S, Brugada R, Rosso R, Guerchicoff A, Pollevick GD, Antzelevitch C Journal: Heart Rhythm Gender-associated differences in pharmacokinetics and anti-arrhythmic effects of flecainide in Japanese patients with supraventricular tachyarrhythmia. Authors: Doki K, Homma M, Kuga K, Aonuma K, Sakai S, Yamaguchi I, Kohda Y Journal: Eur J Clin Pharmacol Flecainide suppresses bidirectional ventricular tachycardia and reverses tachycardia-induced cardiomyopathy in Andersen-Tawil syndrome. Authors: Pellizzón OA, Kalaizich L, Ptácek LJ, Tristani-Firouzi M, Gonzalez MD Journal: J Cardiovasc Electrophysiol Impact of serum flecainide level on control of atrial fibrillation in a case treated with cardiac resynchronization therapy. Authors: Doki K, Homma M, Kuga K, Kawano S, Aonuma K, Yamaguchi I, Kohda Y Journal: J Clin Pharm Ther Action potential experiments complete hERG assay and QT-interval measurements in cardiac preclinical studies. Authors: Ducroq J, Printemps R, Guilbot S, Gardette J, Salvetat C, Le Grand M Journal: J Pharmacol Toxicol Methods Quinidine in short QT syndrome: an old drug for a new disease. Authors: Kaufman ES Journal: J Cardiovasc Electrophysiol Reduction of dispersion of repolarization and prolongation of postrepolarization refractoriness explain the antiarrhythmic effects of quinidine in a model of short QT syndrome. Authors: Milberg P, Tegelkamp R, Osada N, Schimpf R, Wolpert C, Breithardt G, Borggrefe M, Eckardt L Journal: J Cardiovasc Electrophysiol Observations on the safety and effectiveness of dofetilide in patients with paroxysmal atrial fibrillation and normal left ventricular function. Authors: Mykytsey A, Bauman JL, Razminia M, Zheutlin T, Wang T, Saleem M, Leal S, Kehoe RF Journal: J Cardiovasc Pharmacol Ther Further evidence of inherited long QT syndrome gene mutations in antiarrhythmic drug-associated torsades de pointes. Authors: Lehtonen A, Fodstad H, Laitinen-Forsblom P, Toivonen L, Kontula K, Swan H Journal: Heart Rhythm Flecainide cardiotoxicity precipitated by electrolyte imbalance. Caution with thiazide diuretics. Authors: Khavandi A, Walker PR Journal: Emerg Med J Managing cardiovascular collapse in severe flecainide overdose without recourse to extracorporeal therapy. Authors: Devin R, Garrett P, Anstey C Journal: Emerg Med Australas Drug-induced yawning: a review of the French pharmacovigilance database. Authors: Sommet A, Desplas M, Lapeyre-Mestre M, Montastruc JL, Journal: Drug Saf Haemolysis alters plasma flecainide levels in newborn infants. Authors: Vento M, Tudela BF, Escrig R, Sáenz P, Sánchez A, Cano A Journal: Acta Paediatr Flecainide for recurrent malignant ventricular arrhythmias in two siblings with Andersen-Tawil syndrome. Authors: Bökenkamp R, Wilde AA, Schalij MJ, Blom NA Journal: Heart Rhythm [Effect of flecainide on longitudinal and transverse conduction velocities in ventricular myocardium. An experimental study] Authors: Ferrero A, Chorro FJ, Cánoves J, Mainar L, Blasco E, Such L Journal: Rev Esp Cardiol Some patients with paroxysmal atrial fibrillation should carry flecainide or propafenone to self treat. Authors: Camm AJ, Savelieva I Journal: BMJ The cutaneous analgesic effect of class I antiarrhythmic drugs. Authors: Tzeng JI, Cheng KI, Huang KL, Chen YW, Chu KS, Chu CC, Wang JJ Journal: Anesth Analg Anti-arrhythmic effects of I (Na), I (Kr), and combined I (Kr)-I (CaL) blockade in an experimental model of acute stretch-related atrial fibrillation. Authors: Kalifa J, Bernard M, Gout B, Bril A, Cozma D, Laurent P, Chalvidan T, Deharo JC, Djiane P, Cozzone P, Maixent JM Journal: Cardiovasc Drugs Ther Brugada-like electrocardiographic pattern and ventricular fibrillation in a patient with primary hyperparathyroidism. Authors: Wu LS, Wu CT, Hsu LA, Luqman N, Kuo CT Journal: Europace A common SCN5A variant alters the responsiveness of human sodium channels to class I antiarrhythmic agents. Authors: Shuraih M, Ai T, Vatta M, Sohma Y, Merkle EM, Taylor E, Li Z, Xi Y, Razavi M, Towbin JA, Cheng J Journal: J Cardiovasc Electrophysiol Dose-response effect of flecainide in patients with symptomatic paroxysmal atrial fibrillation and/or flutter monitored with trans-telephonic electrocardiography: a multicenter, placebo-controlled, double-blind trial. Authors: Atarashi H, Ogawa S, Inoue H, Hamada C, Journal: Circ J The pharmacological response of ischemia-related atrial fibrillation in dogs: evidence for substrate-specific efficacy. Authors: Rivard L, Sinno H, Shiroshita-Takeshita A, Schram G, Leung TK, Nattel S Journal: Cardiovasc Res Simultaneous ST-segment elevation in the right precordial and inferior leads in Brugada syndrome. Authors: Lombardi F, Potenza S, Beltrami A, Verzoni A, Brugada P, Brugada R Journal: J Cardiovasc Med (Hagerstown) Effects of flecainide and quinidine on arrhythmogenic properties of Scn5a+/- murine hearts modelling the Brugada syndrome. Authors: Stokoe KS, Balasubramaniam R, Goddard CA, Colledge WH, Grace AA, Huang CL Journal: J Physiol Torsades de pointes complicating atrioventricular block: evidence for a genetic predisposition. Authors: Chevalier P, Bellocq C, Millat G, Piqueras E, Potet F, Schott JJ, Baró I, Lemarec H, Barhanin J, Rousson R, Rodriguez-Lafrasse C Journal: Heart Rhythm Familial clustering of lone atrial fibrillation in patients with saddleback-type ST-segment elevation in right precordial leads. Authors: Junttila MJ, Raatikainen MJ, Perkiömäki JS, Hong K, Brugada R, Huikuri HV Journal: Eur Heart J Effect of amiodarone on the serum concentration/dose ratio of metoprolol in patients with cardiac arrhythmia. Authors: Fukumoto K, Kobayashi T, Tachibana K, Kato R, Tanaka K, Komamura K, Kamakura S, Kitakaze M, Ueno K Journal: Drug Metab Pharmacokinet Use of telemedicine in the diagnosis of paroxysmal atrial fibrillation and to monitor the effect of antiarrhythmic drug therapy. Authors: Klingenheben T, Israel CW Journal: Herzschrittmacherther Elektrophysiol Auto-intoxication with flecainide and quinapril: ECG-changes, symptoms and treatment. Authors: Van Reet B, Dens J Journal: Acta Cardiol [Be careful in using flecainide by hemodialyzed patients] Authors: Montagnac R, Schoen E, Aliouche CP, Schillinger F Journal: Nephrol Ther Simultaneous determination of 6 beta-blockers, 3 calcium-channel antagonists, 4 angiotensin-II antagonists and 1 antiarrhythmic drug in post-mortem whole blood by automated solid phase extraction and liquid chromatography mass spectrometry. Method development and robustness testing by experimental design. Authors: Kristoffersen L, Øiestad EL, Opdal MS, Krogh M, Lundanes E, Christophersen AS Journal: J Chromatogr B Analyt Technol Biomed Life Sci [What is your diagnosis? Brugada syndrome] Authors: Kobza R, Zuber M, Erne P Journal: Schweiz Rundsch Med Prax A randomized trial of circumferential pulmonary vein ablation versus antiarrhythmic drug therapy in paroxysmal atrial fibrillation: the APAF Study. Authors: Pappone C, Augello G, Sala S, Gugliotta F, Vicedomini G, Gulletta S, Paglino G, Mazzone P, Sora N, Greiss I, Santagostino A, LiVolsi L, Pappone N, Radinovic A, Manguso F, Santinelli V Journal: J Am Coll Cardiol Overlap syndrome of cardiac sodium channel disease in mice carrying the equivalent mutation of human SCN5A-1795insD. Authors: Remme CA, Verkerk AO, Nuyens D, van Ginneken AC, van Brunschot S, Belterman CN, Wilders R, van Roon MA, Tan HL, Wilde AA, Carmeliet P, de Bakker JM, Veldkamp MW, Bezzina CR Journal: Circulation Altered Na+ channels promote pause-induced spontaneous diastolic activity in long QT syndrome type 3 myocytes. Authors: Fredj S, Lindegger N, Sampson KJ, Carmeliet P, Kass RS Journal: Circ Res Torsade-de-pointes in a patient under flecainide treatment, an unusual case of proarrhythmicity. Authors: Nogales Asensio JM, Moreno Sánchez N, Doncel Vecino LJ, Villar Mariscal C, López-Mínguez JR, Merchán Herrera A Journal: Int J Cardiol Kv1.5 is a major component underlying the A-type potassium current in retinal arteriolar smooth muscle. Authors: McGahon MK, Dawicki JM, Arora A, Simpson DA, Gardiner TA, Stitt AW, Scholfield CN, McGeown JG, Curtis TM Journal: Am J Physiol Heart Circ Physiol Effects of flecainide and quinidine on arrhythmogenic properties of Scn5a+/Delta murine hearts modelling long QT syndrome 3. Authors: Stokoe KS, Thomas G, Goddard CA, Colledge WH, Grace AA, Huang CL Journal: J Physiol Fetal and maternal magnetocardiography during flecainide therapy for supraventricular tachycardia. Authors: Campbell JQ, Best TH, Eswaran H, Lowery CL Journal: Obstet Gynecol Pharmacological and molecular evidence for the involvement of Kv4.3 in ultra-fast activating K+ currents in murine portal vein myocytes. Authors: Yeung SY, Ohya S, Sergeant GP, Pucovský V, Greenwood IA Journal: Br J Pharmacol [Atrioventricular nodal reentry tachycardia in children] Authors: Vislie CH, Mikkelsen RB, Hoff PI, Greve G Journal: Tidsskr Nor Laegeforen Determinants of sudden cardiac death in patients with persistent atrial fibrillation in the rate control versus electrical cardioversion (RACE) study. Authors: Hagens VE, Rienstra M, Van Veldhuisen DJ, Crijns HJ, Van Gelder IC Journal: Am J Cardiol In silico assessment of Y1795C and Y1795H SCN5A mutations: implication for inherited arrhythmogenic syndromes. Authors: Vecchietti S, Grandi E, Severi S, Rivolta I, Napolitano C, Priori SG, Cavalcanti S Journal: Am J Physiol Heart Circ Physiol Transthoracic tissue Doppler imaging of the atria: a novel method to determine the atrial fibrillation cycle length. Authors: Duytschaever M, Heyse A, de Sutter J, Crijns H, Gillebert T, Tavernier R, Tieleman R Journal: J Cardiovasc Electrophysiol Atrial fibrillation: choosing an antiarrhythmic drug. Authors: Rudo T, Kowey P Journal: Curr Cardiol Rep Effect of CYP2D6 genotype on flecainide pharmacokinetics in Japanese patients with supraventricular tachyarrhythmia. Authors: Doki K, Homma M, Kuga K, Kusano K, Watanabe S, Yamaguchi I, Kohda Y Journal: Eur J Clin Pharmacol Cardiac effects of ST-6, a novel cyclohexane dicarboximide derivative. Authors: Takeo S, Tanonaka K Journal: Cardiovasc Drug Rev Diabetes mellitus reduces the antiarrhythmic effect of ion channel blockers. Authors: Ito I, Hayashi Y, Kawai Y, Iwasaki M, Takada K, Kamibayashi T, Yamatodani A, Mashimo T Journal: Anesth Analg Long-term protection of central axons with phenytoin in monophasic and chronic-relapsing EAE. Authors: Black JA, Liu S, Hains BC, Saab CY, Waxman SG Journal: Brain Combined use of 1C and III agents for highly symptomatic, refractory atrial fibrillation. Authors: Narayan G, Akhtar M, Sra J Journal: J Interv Card Electrophysiol Properties of a time-dependent potassium current in pig atrium: evidence for a role of kv1.5 in repolarization. Authors: Ehrlich JR, Hoche C, Coutu P, Metz-Weidmann C, Dittrich W, Hohnloser SH, Nattel S, Gögelein H Journal: J Pharmacol Exp Ther Negative flecainide test in Brugada syndrome patients with previous positive response. Authors: Abello M, Merino JL, Peinado R, Gnoatto M Journal: Europace Too little, too late: chasing atrial fibrillation with sodium channel antagonists. Authors: Anderson ME Journal: J Cardiovasc Electrophysiol Serial cardioversion by class IC Drugs during 4 months of persistent atrial fibrillation in the goat. Authors: Eijsbouts S, Ausma J, Blaauw Y, Schotten U, Duytschaever M, Allessie MA Journal: J Cardiovasc Electrophysiol [Intravenous flecainide administration for conversion of paroxysmal atrial fibrillation in the emergency room] Authors: Antonelli D, Feldman A, Freedberg NA, Darawsha A, Rosenfeld T Journal: Harefuah [Flecainide acetate utilisation review among general practitioners and hospital or office-based cardiologists in France. Obepine: observational study of flecainide] Authors: Liard F, Le Heuzey JY, Jaillon P, Lièvre M, Danchin N Journal: Ann Cardiol Angeiol (Paris) [Permanent His-bundle pacing in patients with infra-Hisian atrioventricular block] Authors: Barba-Pichardo R, Moriña-Vázquez P, Venegas-Gamero J, Maroto-Monserrat F, Cid-Cumplido M, Herrera-Carranza M Journal: Rev Esp Cardiol Diagnostic value of flecainide testing in unmasking SCN5A-related Brugada syndrome. Authors: Meregalli PG, Ruijter JM, Hofman N, Bezzina CR, Wilde AA, Tan HL Journal: J Cardiovasc Electrophysiol Flecainide treatment of fetal tachycardia and hydrops fetalis in a twin pregnancy. Authors: Gerli S, Clerici G, Mattei A, Di Renzo GC Journal: Ultrasound Obstet Gynecol [Life-threatening ventricular tachycardia during flecainide treatment for symptomatic atrial fibrillation in a patient with a structural cardiac disorder] Authors: Rienstra M, Wiesfeld AC, van Veldhuisen DJ, van Gelder IC Journal: Ned Tijdschr Geneeskd [Drug treatment of atrial fibrillation] Authors: Janko S, Hoffmann E Journal: MMW Fortschr Med Brugada-like electrocardiogram pattern: how to stratify the risk for sudden cardiac death. Is sports activity contraindicated? Authors: Delise P, Marras E, Bocchino M Journal: J Cardiovasc Med (Hagerstown) Atrial fibrillation (recent onset). Authors: Lip GY Journal: Clin Evid Antiarrhythmic drugs for maintaining sinus rhythm after cardioversion of atrial fibrillation: a systematic review of randomized controlled trials. Authors: Lafuente-Lafuente C, Mouly S, Longás-Tejero MA, Mahé I, Bergmann JF Journal: Arch Intern Med Effects of gap geometry on conduction through discontinuous radiofrequency lesions. Authors: Pérez FJ, Wood MA, Schubert CM Journal: Circulation [Flecainide controlled-release for prevention of atrial fibrillation relapse] Authors: Simon T, Mary-Krause M, Chatelin A, Thuault M, Jaillon P, Journal: Arch Mal Coeur Vaiss A case of acute ventricular capture threshold rise associated with flecainide acetate. Authors: Kang TS, Yoon YW, Park S, Hong BK, Kim D, Kwon HM, Kim HS Journal: Yonsei Med J Flecainide sensitivity of a Na channel long QT mutation shows an open-channel blocking mechanism for use-dependent block. Authors: Zhu Y, Kyle JW, Lee PJ Journal: Am J Physiol Heart Circ Physiol Successful conversion of equine atrial fibrillation using oral flecainide. Authors: Risberg AI, McGuirk SM Journal: J Vet Intern Med

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