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| ethionamide |
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A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868)
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Additional comments :
(Amidazine, Ethioniamide, Trecator)
Articles
 Ethionamide.
Authors:
Journal: Tuberculosis (Edinb)
Activity of twelve second-line antimicrobial agents against Mycobacterium tuberculosis in Taiwan.
Authors: Lu PL, Peng CF, Hwang JJ, Chen YH
Journal: J Chemother
Gene expression profiling in rat liver treated with compounds inducing phospholipidosis.
Authors: Hirode M, Ono A, Miyagishima T, Nagao T, Ohno Y, Urushidani T
Journal: Toxicol Appl Pharmacol
[A case of multi-drug resistant tuberculosis showing psychiatric adverse effect by cycloserine]
Authors: Fujita J, Sunada K, Hayashi H, Hayashihara K, Saito T
Journal: Kekkaku
Overview of anti-tuberculosis (TB) drugs and their resistance mechanisms.
Authors: Shi R, Itagaki N, Sugawara I
Journal: Mini Rev Med Chem
Organization of the mycobacterial cell wall: a nanoscale view.
Authors: Alsteens D, Verbelen C, Dague E, Raze D, Baulard AR, Dufrêne YF
Journal: Pflugers Arch
Drug resistance in Mycobacterium tuberculosis strains isolated from sputum samples from symptomatic outpatients: Complexo de Manguinhos, Rio de Janeiro, Brazil.
Authors: Mendes JM, Lourenço MC, Ferreira RM, Fonseca Lde S, Saad MH
Journal: J Bras Pneumol
Multidrug-resistant tuberculosis treatment outcomes in Karakalpakstan, Uzbekistan: treatment complexity and XDR-TB among treatment failures.
Authors: Cox HS, Kalon S, Allamuratova S, Sizaire V, Tigay ZN, Rüsch-Gerdes S, Karimovich HA, Kebede Y, Mills C
Journal: PLoS ONE
Type II NADH: menaquinone oxidoreductase of Mycobacterium tuberculosis.
Authors: Teh JS, Yano T, Rubin H
Journal: Infect Disord Drug Targets
Low levels of second-line drug resistance among multidrug-resistant Mycobacterium tuberculosis isolates from Rwanda.
Authors: Umubyeyi A, Rigouts L, Shamputa IC, Dediste A, Struelens M, Portaels F
Journal: Int J Infect Dis
[Case of pulmonary multi-drug resistant tuberculosis with left destroyed lung, treated with pneumonectomy]
Authors: Koyama K, Kawakami K, Harada Y, Yamaryo T, Kimura Y
Journal: Kekkaku
Susceptibility tests to second line drugs and re-treatment of tuberculosis revisiting early experiences.
Authors: de Kantor IN, Barrera L
Journal: Medicina (B Aires)
[Survey of anti-tuberculosis drug-induced severe liver injury in Japan]
Authors: Shigeto E,
Journal: Kekkaku
[Late-occurring cutaneous vasculitis after successful treatment of diffuse lepromatous leprosy: Lucio's phenomenon]
Authors: Fenniche S, Benmously R, Sfia M, Daoud L, Debbiche A, Ben Ayed M, Mokhtar I
Journal: Med Trop (Mars)
[Treatment results of rifampicin (RFP) resistant isoniazid (INH) susceptible tuberculosis, a hospital based study]
Authors: Yoshiyama T, Ogata H, Ito K, Aono A, Wada M
Journal: Kekkaku
[Case of SIADH caused by ethionamide in a patient with pulmonary tuberculosis]
Authors: Nakashita T, Motojima S
Journal: Kekkaku
Mechanism of thioamide drug action against tuberculosis and leprosy.
Authors: Wang F, Langley R, Gulten G, Dover LG, Besra GS, Jacobs WR, Sacchettini JC
Journal: J Exp Med
EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets.
Authors: Dover LG, Alahari A, Gratraud P, Gomes JM, Bhowruth V, Reynolds RC, Besra GS, Kremer L
Journal: Antimicrob Agents Chemother
Absence of an association between Mycobacterium tuberculosis genotype and clinical features in children with tuberculous meningitis.
Authors: Maree F, Hesseling AC, Schaaf HS, Marais BJ, Beyers N, van Helden P, Warren RM, Schoeman JF
Journal: Pediatr Infect Dis J
[A controlled clinical trial of long course chemotherapy regimens containing rifabutin in the treatment of multi-drug resistant pulmonary tuberculosis]
Authors: Zhu LZ, Fu Y, Chu NH, Ye ZZ, Xiao HP, Wang W, Yuan SL, Zhang X, Luo YA, Ma LP
Journal: Zhonghua Jie He He Hu Xi Za Zhi
Molecular characterization of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis from the USA.
Authors: Guo H, Seet Q, Denkin S, Parsons L, Zhang Y
Journal: J Med Microbiol
Metabolism of thioamides by Ralstonia pickettii TA.
Authors: Dodge AG, Richman JE, Johnson G, Wackett LP
Journal: Appl Environ Microbiol
Combinations of R207910 with drugs used to treat multidrug-resistant tuberculosis have the potential to shorten treatment duration.
Authors: Lounis N, Veziris N, Chauffour A, Truffot-Pernot C, Andries K, Jarlier V
Journal: Antimicrob Agents Chemother
Selective intracellular accumulation of the major metabolite issued from the activation of the prodrug ethionamide in mycobacteria.
Authors: Hanoulle X, Wieruszeski JM, Rousselot-Pailley P, Landrieu I, Locht C, Lippens G, Baulard AR
Journal: J Antimicrob Chemother
API TB Consensus Guidelines 2006: Management of pulmonary tuberculosis, extra-pulmonary tuberculosis and tuberculosis in special situations.
Authors:
Journal: J Assoc Physicians India
The efficacy of certain anti-tuberculosis drugs is affected by binding to alpha-1-acid glycoprotein.
Authors: Johnson DA, Smith KD
Journal: Biomed Chromatogr
[The rates of resistance to second-line drugs in multidrug resistant Mycobacterium tuberculosis strains]
Authors: Kayali R, Cöplü N, Ceyhan I, Ocak F, Citil BE, Esen B
Journal: Mikrobiyol Bul
Multidrug-resistant tuberculosis without HIV infection: success with individualised therapy.
Authors: Escudero E, Peña JM, Alvarez-Sala R, Vázquez JJ, Ortega A
Journal: Int J Tuberc Lung Dis
Oxidative activation of thiacetazone by the Mycobacterium tuberculosis flavin monooxygenase EtaA and human FMO1 and FMO3.
Authors: Qian L, Ortiz de Montellano PR
Journal: Chem Res Toxicol
Pulmonary Mycobacterium kansasii infection in Israel, 1999-2004: clinical features, drug susceptibility, and outcome.
Authors: Shitrit D, Baum GL, Priess R, Lavy A, Shitrit AB, Raz M, Shlomi D, Daniele B, Kramer MR
Journal: Chest
A clinical trial of ethionamide and prothionamide for treatment of lepromatous leprosy.
Authors: Fajardo TT, Guinto RS, Cellona RV, Abalos RM, Dela Cruz EC, Gelber RH
Journal: Am J Trop Med Hyg
Multicenter laboratory validation of the BACTEC MGIT 960 technique for testing susceptibilities of Mycobacterium tuberculosis to classical second-line drugs and newer antimicrobials.
Authors: Rüsch-Gerdes S, Pfyffer GE, Casal M, Chadwick M, Siddiqi S
Journal: J Clin Microbiol
A community-based TB drug susceptibility study in Mimika District, Papua Province, Indonesia.
Authors: Kelly PM, Ardian M, Waramori G, Anstey NM, Syahrial H, Tjitra E, Bastian I, Maguire GP, Lumb R
Journal: Int J Tuberc Lung Dis
[Current situation of contacts examination and chemoprophylaxis for persons exposed to multi-drug resistant tuberculosis in ordinance-designated cities in Japan]
Authors: Sasaki Y, Yamagishi F, Yagi T
Journal: Kekkaku
Flux balance analysis of mycolic acid pathway: targets for anti-tubercular drugs.
Authors: Raman K, Rajagopalan P, Chandra N
Journal: PLoS Comput Biol
Exploring drug action on Mycobacterium tuberculosis using affymetrix oligonucleotide genechips.
Authors: Fu LM
Journal: Tuberculosis (Edinb)
Insights into mechanisms of induction and ligands recognition in the transcriptional repressor EthR from Mycobacterium tuberculosis.
Authors: Frénois F, Baulard AR, Villeret V
Journal: Tuberculosis (Edinb)
Simple means to alleviate sensitivity loss by trifluoroacetic acid (TFA) mobile phases in the hydrophilic interaction chromatography-electrospray tandem mass spectrometric (HILIC-ESI/MS/MS) bioanalysis of basic compounds.
Authors: Shou WZ, Naidong W
Journal: J Chromatogr B Analyt Technol Biomed Life Sci
Molecular characterization of isoniazid-resistant Mycobacterium tuberculosis isolates collected in Australia.
Authors: Lavender C, Globan M, Sievers A, Billman-Jacobe H, Fyfe J
Journal: Antimicrob Agents Chemother
Mycobacterium kansasii: antibiotic susceptibility and PCR-restriction analysis of clinical isolates.
Authors: da Silva Telles MA, Chimara E, Ferrazoli L, Riley LW
Journal: J Med Microbiol
Rifapentine, moxifloxacin, or DNA vaccine improves treatment of latent tuberculosis in a mouse model.
Authors: Nuermberger E, Tyagi S, Williams KN, Rosenthal I, Bishai WR, Grosset JH
Journal: Am J Respir Crit Care Med
[Resistance to antituberculous drugs]
Authors: Veziris N, Cambau E, Sougakoff W, Robert J, Jarlier V
Journal: Arch Pediatr
[Extrathoracic tuberculosis in Siberia and the Far East]
Authors: Kul'chavenia EV, Brizhatiuk EV, Khomiakov VT
Journal: Probl Tuberk Bolezn Legk
Hypothyroidism due to ethionamide.
Authors: McDonnell ME, Braverman LE, Bernardo J
Journal: N Engl J Med
Altered expression profile of mycobacterial surface glycopeptidolipids following treatment with the antifungal azole inhibitors econazole and clotrimazole.
Authors: Burguière A, Hitchen PG, Dover LG, Dell A, Besra GS
Journal: Microbiology
Molecular typing of Mycobacterium bovis isolates from south-east Brazil by spoligotyping and RFLP.
Authors: Zanini MS, Moreira EC, Salas CE, Lopes MT, Barouni AS, Roxo E, Telles MA, Zumarraga MJ
Journal: J Vet Med B Infect Dis Vet Public Health
Monitoring of the ethionamide pro-drug activation in mycobacteria by (1)H high resolution magic angle spinning NMR.
Authors: Hanoulle X, Wieruszeski JM, Rousselot-Pailley P, Landrieu I, Baulard AR, Lippens G
Journal: Biochem Biophys Res Commun
Differential network expression during drug and stress response.
Authors: Cabusora L, Sutton E, Fulmer A, Forst CV
Journal: Bioinformatics
[Doping in the peloton of antituberculosis drugs]
Authors: Baulard AR
Journal: Med Sci (Paris)
Resistance of multidrug-resistant strains of Mycobacterium tuberculosis from the Archangel oblast, Russia, to second-line anti-tuberculosis drugs.
Authors: Toungoussova OS, Mariandyshev AO, Bjune G, Caugant DA, Sandven P
Journal: Eur J Clin Microbiol Infect Dis
Second-line drug susceptibilities of Thai multidrug-resistant Mycobacterium tuberculosis isolates.
Authors: Prammananan T, Arjratanakool W, Chaiprasert A, Tingtoy N, Leechawengwong M, Asawapokee N, Leelarasamee A, Dhiraputra C
Journal: Int J Tuberc Lung Dis
Treatment outcome of multidrug-resistant tuberculosis among Vietnamese immigrants.
Authors: Ward HA, Marciniuk DD, Hoeppner VH, Jones W
Journal: Int J Tuberc Lung Dis
Drug resistance in tuberculosis.
Authors: Mitchison DA
Journal: Eur Respir J
[A case of pulmonary multiresistant Mycobacterium bovis tuberculosis in Madagascar]
Authors: Ramarokoto H, Andrianasolo D, Rasolonavalona T, Ramaroson F, Razafitsiarovana I, Vincent V, Ratsimba L, Rasolofo Razanamparany V
Journal: Arch Inst Pasteur Madagascar
Analysis of Mycobacterium tuberculosis isolates from treatment failure patients living in East Timor.
Authors: Kelly PM, Lumb R, Pinto A, da Costa G, Sarmento J, Bastian I
Journal: Int J Tuberc Lung Dis
Altered NADH/NAD+ ratio mediates coresistance to isoniazid and ethionamide in mycobacteria.
Authors: Vilchèze C, Weisbrod TR, Chen B, Kremer L, Hazbón MH, Wang F, Alland D, Sacchettini JC, Jacobs WR
Journal: Antimicrob Agents Chemother
Drug susceptibility of Brazilian strains of Mycobacterium bovis using traditional and molecular techniques.
Authors: Parreiras PM, Lobato FC, Alencar AP, Figueiredo T, Gomes HM, Boéchat N, Lage AP, Assis RA, Pereira MA, Souza PR, Mota PM, Suffys PN
Journal: Mem Inst Oswaldo Cruz
Electron transfer kinetics and mechanistic study of the thionicotinamide coordinated to the pentacyanoferrate(III)/(II) complexes: a model system for the in vitro activation of thioamides anti-tuberculosis drugs.
Authors: Sousa EH, Pontes DL, Diógenes IC, Lopes LG, Oliveira JS, Basso LA, Santos DS, Moreira IS
Journal: J Inorg Biochem
Inhibitory effect of antituberculosis drugs on human cytochrome P450-mediated activities.
Authors: Nishimura Y, Kurata N, Sakurai E, Yasuhara H
Journal: J Pharmacol Sci
Pharmacokinetics and relative bioavailability of clofazimine in relation to food, orange juice and antacid.
Authors: Nix DE, Adam RD, Auclair B, Krueger TS, Godo PG, Peloquin CA
Journal: Tuberculosis (Edinb)
Outcome of treatment of multidrug resistant tuberculosis.
Authors: Senaratne WV
Journal: Ceylon Med J
Adjuvant interferon gamma in patients with drug - resistant pulmonary tuberculosis: a pilot study.
Authors: Suárez-Méndez R, García-García I, Fernández-Olivera N, Valdés-Quintana M, Milanés-Virelles MT, Carbonell D, Machado-Molina D, Valenzuela-Silva CM, López-Saura PA
Journal: BMC Infect Dis
Multidrug resistant miliary tuberculosis and Pott's disease in an immunocompetent patient.
Authors: Shah A, Panjabi C, Maurya V, Khanna P
Journal: Saudi Med J
Structure of EthR in a ligand bound conformation reveals therapeutic perspectives against tuberculosis.
Authors: Frénois F, Engohang-Ndong J, Locht C, Baulard AR, Villeret V
Journal: Mol Cell
Crystal structure of the TetR/CamR family repressor Mycobacterium tuberculosis EthR implicated in ethionamide resistance.
Authors: Dover LG, Corsino PE, Daniels IR, Cocklin SL, Tatituri V, Besra GS, Fütterer K
Journal: J Mol Biol
Antituberculous activity of some aryl semicarbazone derivatives.
Authors: Sriram D, Yogeeswari P, Thirumurugan R
Journal: Bioorg Med Chem Lett
Treatment and follow-up of HIV-negative multidrug-resistant tuberculosis patients in an infectious diseases reference hospital, Buenos Aires, Argentina.
Authors: Palmero DJ, Ambroggi M, Brea A, De Lucas M, Fulgenzi A, Martínez D, Mosca C, Musella R, Natiello M, Gonzalez C, Abbate E
Journal: Int J Tuberc Lung Dis
Surveillance of Mycobacterium tuberculosis susceptibility to second-line drugs in Hong Kong, 1995-2002, after the implementation of DOTS-plus.
Authors: Kam KM, Yip CW
Journal: Int J Tuberc Lung Dis
A microplate indicator-based method for determining the susceptibility of multidrug-resistant Mycobacterium tuberculosis to antimicrobial agents.
Authors: Morcillo N, Di Giulio B, Testani B, Pontino M, Chirico C, Dolmann A
Journal: Int J Tuberc Lung Dis
A case study in Hansen's disease acquired after heart transplant.
Authors: Launius BK, Brown PA, Cush E, Mancini MC
Journal: Crit Care Nurs Q
Use of MGIT 960 for rapid quantitative measurement of the susceptibility of Mycobacterium tuberculosis complex to ciprofloxacin and ethionamide.
Authors: Huang TS, Lee SS, Tu HZ, Huang WK, Chen YS, Huang CK, Wann SR, Lin HH, Liu YC
Journal: J Antimicrob Chemother
EthR, a repressor of the TetR/CamR family implicated in ethionamide resistance in mycobacteria, octamerizes cooperatively on its operator.
Authors: Engohang-Ndong J, Baillat D, Aumercier M, Bellefontaine F, Besra GS, Locht C, Baulard AR
Journal: Mol Microbiol
ethA, inhA, and katG loci of ethionamide-resistant clinical Mycobacterium tuberculosis isolates.
Authors: Morlock GP, Metchock B, Sikes D, Crawford JT, Cooksey RC
Journal: Antimicrob Agents Chemother
Kinetic spectrophotometric determination of some sulfur containing compounds in pharmaceutical preparations and human serum.
Authors: Walash MI, Metwally ME, El-Brashy AM, Abdelal AA
Journal: Farmaco
Lepromatous leprosy in a heart transplant recipient.
Authors: Modi K, Mancini M, Joyce MP
Journal: Am J Transplant
The prodrug activator EtaA from Mycobacterium tuberculosis is a Baeyer-Villiger monooxygenase.
Authors: Fraaije MW, Kamerbeek NM, Heidekamp AJ, Fortin R, Janssen DB
Journal: J Biol Chem
Evaluation of indirect susceptibility testing of Mycobacterium tuberculosis to the first- and second-line, and alternative drugs by the newer MB/BacT system.
Authors: Barreto AM, Araújo JB, de Melo Medeiros RF, de Souza Caldas PC
Journal: Mem Inst Oswaldo Cruz
Resazurin microtiter assay plate testing of Mycobacterium tuberculosis susceptibilities to second-line drugs: rapid, simple, and inexpensive method.
Authors: Martin A, Camacho M, Portaels F, Palomino JC
Journal: Antimicrob Agents Chemother
Comparative roles of levofloxacin and ofloxacin in the treatment of multidrug-resistant tuberculosis: preliminary results of a retrospective study from Hong Kong.
Authors: Yew WW, Chan CK, Leung CC, Chau CH, Tam CM, Wong PC, Lee J
Journal: Chest
Fluoroquinolone-containing third-line regimen against Mycobacterium tuberculosis in vivo.
Authors: Veziris N, Truffot-Pernot C, Aubry A, Jarlier V, Lounis N
Journal: Antimicrob Agents Chemother
Incorporation of antibiotics in liposomes designed for tuberculosis therapy by inhalation.
Authors: Justo OR, Moraes AM
Journal: Drug Deliv
The 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) assay as rapid colorimetric method for determination of antibiotic susceptibility of clinical Mycobacterium tuberculosis isolates in liquid medium.
Authors: De Logu A, Borgna R, Uda P, Sanna A, Pellerano ML, Saddi B
Journal: Clin Lab
Gatifloxacin and ethionamide as the foundation for therapy of tuberculosis.
Authors: Cynamon MH, Sklaney M
Journal: Antimicrob Agents Chemother
Chronic cases of tuberculosis in Casablanca, Morocco.
Authors: El Baghdadi J, Remus N, Laaboudi L, Benslimane A
Journal: Int J Tuberc Lung Dis
Inactivation of mshB, a key gene in the mycothiol biosynthesis pathway in Mycobacterium smegmatis.
Authors: Rawat M, Kovacevic S, Billman-Jacobe H, Av-Gay Y
Journal: Microbiology
Primary MDR-TB of the breast.
Authors: Kumar P, Sharma N
Journal: Indian J Chest Dis Allied Sci
Inhibition of InhA activity, but not KasA activity, induces formation of a KasA-containing complex in mycobacteria.
Authors: Kremer L, Dover LG, Morbidoni HR, Vilchèze C, Maughan WN, Baulard A, Tu SC, Honoré N, Deretic V, Sacchettini JC, Locht C, Jacobs WR, Besra GS
Journal: J Biol Chem
Multidrug-resistant tuberculosis in pregnancy: case report and review of the literature.
Authors: Lessnau KD, Qarah S
Journal: Chest
Activities of moxifloxacin alone and in combination with other antimicrobial agents against multidrug-resistant Mycobacterium tuberculosis infection in BALB/c mice.
Authors: Fattorini L, Tan D, Iona E, Mattei M, Giannoni F, Brunori L, Recchia S, Orefici G
Journal: Antimicrob Agents Chemother
Prevalence of acquired MDR-TB and HIV co-infection.
Authors: Deivanayagam CN, Rajasekaran S, Venkatesan R, Mahilmaran A, Ahmed PR, Annadurai S, Kumar S, Chandrasekar C, Ravichandran N, Pencillaiah R
Journal: Indian J Chest Dis Allied Sci
Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis.
Authors: Larsen MH, Vilchèze C, Kremer L, Besra GS, Parsons L, Salfinger M, Heifets L, Hazbon MH, Alland D, Sacchettini JC, Jacobs WR
Journal: Mol Microbiol
Therapeutic drug monitoring in the treatment of tuberculosis.
Authors: Peloquin CA
Journal: Drugs
Population pharmacokinetics of ethionamide in patients with tuberculosis.
Authors: Zhu M, Namdar R, Stambaugh JJ, Starke JR, Bulpitt AE, Berning SE, Peloquin CA
Journal: Tuberculosis (Edinb)
Comparative study on the use of solid media: Löwenstein-Jensen and Ogawa in the determination of anti-tuberculosis drug susceptibility.
Authors: Tanoue S, Mitarai S, Shishido H
Journal: Tuberculosis (Edinb)
Long-term follow up of childhood tuberculous meningitis.
Authors: Schoeman J, Wait J, Burger M, van Zyl F, Fertig G, van Rensburg AJ, Springer P, Donald P
Journal: Dev Med Child Neurol
Drugs that inhibit mycolic acid biosynthesis in Mycobacterium tuberculosis.
Authors: Schroeder EK, de Souza N, Santos DS, Blanchard JS, Basso LA
Journal: Curr Pharm Biotechnol
Feasibility and cost-effectiveness of standardised second-line drug treatment for chronic tuberculosis patients: a national cohort study in Peru.
Authors: Suárez PG, Floyd K, Portocarrero J, Alarcón E, Rapiti E, Ramos G, Bonilla C, Sabogal I, Aranda I, Dye C, Raviglione M, Espinal MA
Journal: Lancet
[Medication-induced hepatic lesions in patients with pulmonary tuberculosis]
Authors: Gned'ko NI
Journal: Voen Med Zh
Direct sensitivity test of the MB/BacT system.
Authors: Barreto AM, Araujo JB, Medeiros RF, Caldas PC
Journal: Mem Inst Oswaldo Cruz
[Multicenter evaluation of a newly developed microdilution test, brothMIC NTM to determine minimum inhibitory concentrations of antimicrobial agents for nontuberculous mycobacteria]
Authors: Yamane N, Onaga S, Saitoh H, Toyoshima S, Shimojima M, Kawahara S, Takashima T, Yamashita T
Journal: Rinsho Byori
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