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| doxepin |
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A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
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Additional comments :
(Apo-Doxepin, Aponal, Deptran, Desidox, Doneurin, Doxepia, Espadox, Mareen, Novo-Doxepin, Prudoxin, Quitaxon, Sinequan, Xepin, Zonalon)
Articles
 Brain histamine H1 receptor occupancy of orally administered antihistamines, bepotastine and diphenhydramine, measured by PET with 11C-doxepin.
Authors: Tashiro M, Duan X, Kato M, Miyake M, Watanuki S, Ishikawa Y, Funaki Y, Iwata R, Itoh M, Yanai K
Journal: Br J Clin Pharmacol
Doxepin rinse for management of mucositis pain in patients with cancer: one week follow-up of topical therapy.
Authors: Epstein JB, Epstein JD, Epstein MS, Oien H, Truelove EL
Journal: Spec Care Dentist
Microwave-assisted extraction of tricyclic antidepressants from human serum followed by high performance liquid chromatography determination.
Authors: Wo?niakiewicz M, Wietecha-Pos?uszny R, Garbacik A, Ko?cielniak P
Journal: J Chromatogr A
Treatment options for the relief of chronic idiopathic urticaria symptoms.
Authors: Fromer L
Journal: South Med J
[Spectrometric study on the interaction of doxepin hydrochloride and fast green and its application]
Authors: Wu CK, Feng SL, Fan J
Journal: Guang Pu Xue Yu Guang Pu Fen Xi
[Potentially inappropriate drugs for geriatric patients]
Authors: Kosi?ska K, Brandys J
Journal: Przegl Lek
Efficacy and safety of doxepin 1 mg, 3 mg, and 6 mg in adults with primary insomnia.
Authors: Roth T, Rogowski R, Hull S, Schwartz H, Koshorek G, Corser B, Seiden D, Lankford A
Journal: Sleep
Recent advances in pathophysiology and current management of itch.
Authors: Greaves MW
Journal: Ann Acad Med Singapore
Simultaneous determination of psychotropic drugs in human urine by capillary electrophoresis with electrochemiluminescence detection.
Authors: Li J, Zhao F, Ju H
Journal: Anal Chim Acta
A fatal doxepin poisoning associated with a defective CYP2D6 genotype.
Authors: Koski A, Ojanperä I, Sistonen J, Vuori E, Sajantila A
Journal: Am J Forensic Med Pathol
Cetirizine, doxepine, and hydroxyzine in the treatment of pruritus due to sulfur mustard: a randomized clinical trial.
Authors: Shohrati M, Davoudi SM, Keshavarz S, Sadr B, Tajik A
Journal: Cutan Ocul Toxicol
Novel therapeutic usage of low-dose doxepin hydrochloride.
Authors: Singh H, Becker PM
Journal: Expert Opin Investig Drugs
Development, validation and application of the HPLC method for determination of mianserin in human serum.
Authors: ?ukaszkiewicz J, Piwowarska J, Skarzy?ska E, ?ojewska MS, Pachecka J
Journal: Acta Pol Pharm
Development of an HPLC method for the monitoring of tricyclic antidepressants in biofluids.
Authors: Samanidou VF, Nika MK, Papadoyannis IN
Journal: J Sep Sci
Supported liquid membranes in hollow fiber liquid-phase microextraction (LPME)--practical considerations in the three-phase mode.
Authors: Bårdstu KF, Ho TS, Rasmussen KE, Pedersen-Bjergaard S, Jönsson JA
Journal: J Sep Sci
Frequency of different anti-depressants associated with suicides and drug deaths.
Authors: Drasch G, Dahlmann F, von Meyer L, Roider G, Eisenmenger W
Journal: Int J Legal Med
Interpreting tricyclic antidepressant measurements in urine in an emergency department setting: comparison of two qualitative point-of-care urine tricyclic antidepressant drug immunoassays with quantitative serum chromatographic analysis.
Authors: Melanson SE, Lewandrowski EL, Griggs DA, Flood JG
Journal: J Anal Toxicol
Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin.
Authors: Duncan RS, McPate MJ, Ridley JM, Gao Z, James AF, Leishman DJ, Leaney JL, Witchel HJ, Hancox JC
Journal: Biochem Pharmacol
Treating the health, quality of life, and functional impairments in insomnia.
Authors: Krystal AD
Journal: J Clin Sleep Med
Quantification of tricyclic antidepressants and monoamine oxidase inhibitors by high-performance liquid chromatography-tandem mass spectrometry in whole blood.
Authors: Titier K, Castaing N, Le-Déodic M, Le-Bars D, Moore N, Molimard M
Journal: J Anal Toxicol
Potentially inappropriate prescribing among Australian veterans and war widows/widowers.
Authors: Roughead EE, Anderson B, Gilbert AL
Journal: Intern Med J
[Intoxication with a tricyclic antidepressant]
Authors: Sakka SG, Kuethe F, Demme U, Hüttemann E
Journal: Anaesthesist
Correlates of low-dosage treatment with antidepressants by psychiatrists and general practitioners.
Authors: Schotte K, Linden M
Journal: Pharmacoepidemiol Drug Saf
A randomized controlled clinical trial comparing "guideline exposed" and "guideline naive" physicians in respect to dosage selection and treatment outcome with doxepin in depressive disorders.
Authors: Linden M, Schotte K
Journal: Pharmacopsychiatry
Patterns and prevalence of antidepressant drug use in the German state of Baden-Wuerttemberg: a prescription-based analysis.
Authors: Ufer M, Meyer SA, Junge O, Selke G, Volz HP, Hedderich J, Gleiter CH
Journal: Pharmacoepidemiol Drug Saf
Differential neurotoxicity of tricyclic antidepressants and novel derivatives in vitro in a dorsal root ganglion cell culture model.
Authors: Haller I, Lirk P, Keller C, Wang GK, Gerner P, Klimaschewski L
Journal: Eur J Anaesthesiol
Motor cortex excitability after vagus nerve stimulation in major depression.
Authors: Bajbouj M, Gallinat J, Lang UE, Hellen F, Vesper J, Lisanby SH, Danker-Hopfe H, Neu P
Journal: J Clin Psychopharmacol
[Molecular imaging of histamine receptors in the human brain]
Authors: Tashiro M, Yanai K
Journal: Brain Nerve
Comparison of hydroxyzine and doxepin in treatment of pruritus due to sulfur mustard.
Authors: Shohrati M, Tajik A, Harandi AA, Davoodi SM, Akmasi M
Journal: Skinmed
Management of pain in cancer patients with oral mucositis: follow-up of multiple doses of doxepin oral rinse.
Authors: Epstein JB, Epstein JD, Epstein MS, Oien H, Truelove EL
Journal: J Pain Symptom Manage
Release of non-neuronal acetylcholine from the isolated human placenta is affected by antidepressants.
Authors: Wessler I, Herschel S, Bittinger F, Kirkpatrick CJ
Journal: Life Sci
Antidepressants for smoking cessation.
Authors: Hughes JR, Stead LF, Lancaster T
Journal: Cochrane Database Syst Rev
[Cenesthesia as a rare differential diagnosis of persistent idiopathic facial pain]
Authors: Steiner J, Bogerts B, Hoffmeyer D, Brinkers M
Journal: Nervenarzt
Simultaneous determination of psychoactive drugs and their metabolites in aqueous matrices by liquid chromatography mass Spectrometry.
Authors: Hummel D, Löffler D, Fink G, Ternes TA
Journal: Environ Sci Technol
Anticonvulsant hypersensitivity syndrome: cross-reactivity with tricyclic antidepressant agents.
Authors: Seitz CS, Pfeuffer P, Raith P, Bröcker EB, Trautmann A
Journal: Ann Allergy Asthma Immunol
Delusional denial of pregnancy as a special form of Cotard's syndrome: case report and review of the literature.
Authors: Walloch JE, Klauwer C, Lanczik M, Brockington IF, Kornhuber J
Journal: Psychopathology
Consequences of treated water recycling as regards pharmaceuticals and drugs in surface and ground waters of a medium-sized Mediterranean catchment.
Authors: Rabiet M, Togola A, Brissaud F, Seidel JL, Budzinski H, Elbaz-Poulichet F
Journal: Environ Sci Technol
Antidepressant therapy in tinnitus.
Authors: Robinson SK, Viirre ES, Stein MB
Journal: Hear Res
Parkinsonism-hyperpyrexia syndrome: the role of electroconvulsive therapy.
Authors: Meagher LJ, McKay D, Herkes GK, Needham M
Journal: J Clin Neurosci
The physiological and pathophysiological roles of neuronal histamine: an insight from human positron emission tomography studies.
Authors: Yanai K, Tashiro M
Journal: Pharmacol Ther
The complexity of active metabolites in therapeutic drug monitoring of psychotropic drugs.
Authors: Hendset M, Haslemo T, Rudberg I, Refsum H, Molden E
Journal: Pharmacopsychiatry
Oral doxepin rinse: the analgesic effect and duration of pain reduction in patients with oral mucositis due to cancer therapy.
Authors: Epstein JB, Epstein JD, Epstein MS, Oien H, Truelove EL
Journal: Anesth Analg
Management of sleep disturbance associated with atopic dermatitis.
Authors: Kelsay K
Journal: J Allergy Clin Immunol
Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach.
Authors: Kirchherr H, Kühn-Velten WN
Journal: J Chromatogr B Analyt Technol Biomed Life Sci
Study of the interaction between doxepin hydrochloride and bovine serum albumin by spectroscopic techniques.
Authors: Kandagal PB, Seetharamappa J, Ashoka S, Shaikh SM, Manjunatha DH
Journal: Int J Biol Macromol
Increased BDNF serum concentration in fibromyalgia with or without depression or antidepressants.
Authors: Laske C, Stransky E, Eschweiler GW, Klein R, Wittorf A, Leyhe T, Richartz E, Köhler N, Bartels M, Buchkremer G, Schott K
Journal: J Psychiatr Res
Doxepin has a potent and long-acting spinal anesthetic effect in rats.
Authors: Cheng BC, Chan BR, Chen YW, Chu KS, Cheng KI, Wang JJ, Chu CC
Journal: Kaohsiung J Med Sci
Novel two-stage screening procedure leads to the identification of a new class of transfection enhancers.
Authors: Neukamm B, Weimann A, Wu S, Danevad M, Lang C, Gessner R
Journal: J Gene Med
Use of psychotropic medications in treating mood disorders during lactation : practical recommendations.
Authors: Eberhard-Gran M, Eskild A, Opjordsmoen S
Journal: CNS Drugs
Nephrogenic fibrosing dermopathy in a patient with acute renal failure never requiring dialysis.
Authors: Cassis TB, Jackson JM, Sonnier GB, Callen JP
Journal: Int J Dermatol
A fully automated turbulent-flow liquid chromatography-tandem mass spectrometry technique for monitoring antidepressants in human serum.
Authors: Sauvage FL, Gaulier JM, Lachâtre G, Marquet P
Journal: Ther Drug Monit
Brain histamine H receptor occupancy of orally administered antihistamines measured by positron emission tomography with (11)C-doxepin in a placebo-controlled crossover study design in healthy subjects: a comparison of olopatadine and ketotifen.
Authors: Tashiro M, Mochizuki H, Sakurada Y, Ishii K, Oda K, Kimura Y, Sasaki T, Ishiwata K, Yanai K
Journal: Br J Clin Pharmacol
The management of tricyclic antidepressant poisoning : the role of gut decontamination, extracorporeal procedures and fab antibody fragments.
Authors: Dargan PI, Colbridge MG, Jones AL
Journal: Toxicol Rev
Doxepin by topical application and intrathecal route in rats.
Authors: Gerner P, Srinivasa V, Zizza AM, Zhuang ZY, Luo S, Zurakowski D, Eappen S, Wang G
Journal: Anesth Analg
Excess fatality from desipramine in children and adolescents.
Authors: Amitai Y, Frischer H
Journal: J Am Acad Child Adolesc Psychiatry
Adult unilateral periventricular pseudocysts with ipsilateral headache.
Authors: Finsterer J, Kopsa W
Journal: Clin Neurol Neurosurg
Tissue injury from tricyclic antidepressants used as local anesthetics.
Authors: Barnet CS, Louis DN, Kohane DS
Journal: Anesth Analg
Itch in systemic disease: therapeutic options.
Authors: Greaves MW
Journal: Dermatol Ther
Influence of the structure of the hydrophobe on the ideality of mixing in micelles in binary mixtures of amphiphilic tricyclic drugs.
Authors: Taboada P, Attwood D, Mosquera V
Journal: J Colloid Interface Sci
Use of reference tissue models for quantification of histamine H1 receptors in human brain by using positron emission tomography and [11c]doxepin.
Authors: Suzuki A, Tashiro M, Kimura Y, Mochizuki H, Ishii K, Watabe H, Yanai K, Ishiwata K, Ishii K
Journal: Ann Nucl Med
Pharmacologic and nonpharmacologic treatments of insomnia.
Authors: Becker PM
Journal: Neurol Clin
High-performance liquid chromatography of some basic drugs on a n-octadecylphosphonic acid modified magnesia-zirconia stationary phase.
Authors: He HB, Feng YQ, Da SL, Hu ZX, Qu L
Journal: J Sep Sci
QT prolongation and syncope with methadone, doxepin, and a beta-blocker.
Authors: Rademacher S, Dietz R, Haverkamp W
Journal: Ann Pharmacother
On-line pretreatment using methylcellulose-immobilized cation-exchange restricted access media for direct liquid chromatography/mass spectrometric determination of basic drugs in plasma.
Authors: Kawano S, Takahashi M, Hine T, Yamamoto E, Asakawa N
Journal: Rapid Commun Mass Spectrom
Studies of the inhibition of serum pseudocholinesterase activity in vitro by commonly used drugs.
Authors: Bailey DN, Briggs JR
Journal: Am J Clin Pathol
Differential block of N-propyl derivatives of amitriptyline and doxepin for sciatic nerve block in rats.
Authors: Gerner P, Luo SH, Zhuang ZY, Djalali AG, Zizza AM, Myers RR, Wang GK
Journal: Reg Anesth Pain Med
[Clinical observation on treatment of dysthymia with combined use of Xiaochaihu Decoction and doxepin]
Authors: Zhang XZ, Li ZJ
Journal: Zhong Xi Yi Jie He Xue Bao
Impact of the CYP2D6 ultra-rapid metabolizer genotype on doxepin pharmacokinetics and serotonin in platelets.
Authors: Kirchheiner J, Henckel HB, Franke L, Meineke I, Tzvetkov M, Uebelhack R, Roots I, Brockmöller J
Journal: Pharmacogenet Genomics
Treatment of polypharmacy overdose with multimodality extracorporeal life support.
Authors: Maclaren G, Butt W, Cameron P, Preovolos A, McEgan R, Marasco S
Journal: Anaesth Intensive Care
Approach to therapy in chronic urticaria: when benadryl is not enough.
Authors: Tilles SA
Journal: Allergy Asthma Proc
Intrathecal administration of doxepin attenuated development of formalin-induced pain in rats.
Authors: Wordliczek J, Banach M, Labuz D, Przewlocka B
Journal: J Neural Transm
Densitometric high performance thin-layer chromatography identification and quantitative analysis of psychotropic drugs.
Authors: Ma?lanka A, Krzek J
Journal: J AOAC Int
Histamine H1 receptors in schizophrenic patients measured by positron emission tomography.
Authors: Iwabuchi K, Ito C, Tashiro M, Kato M, Kano M, Itoh M, Iwata R, Matsuoka H, Sato M, Yanai K
Journal: Eur Neuropsychopharmacol
Extractive spectrophotometric methods for the determination of doxepin hydrochloride in pharmaceutical preparations using titanium (IV) and iron (III) thiocyanate complexes.
Authors: Misiuk W
Journal: Farmaco
Simplified PET measurement for evaluating histamine H1 receptors in human brains using [11C]doxepin.
Authors: Mochizuki H, Kimura Y, Ishii K, Oda K, Sasaki T, Tashiro M, Yanai K, Ishiwata K
Journal: Nucl Med Biol
Application of copper (II) in spectrophotometric determination of some drugs of aliphatic amine nature.
Authors: Somogyi E, Piotrowska J, Rzeszutko W
Journal: Acta Pol Pharm
Current use of selective serotonin reuptake inhibitors and risk of acute myocardial infarction.
Authors: Schlienger RG, Fischer LM, Jick H, Meier CR
Journal: Drug Saf
Doxepin inhibits CYP2D6 activity in vivo.
Authors: Szewczuk-Bogus?awska M, Kiejna A, Besz?ej JA, Orzechowska-Juzwenko K, Milejski P
Journal: Pol J Pharmacol
Risk of fetal exposure to tricyclic antidepressants.
Authors: Wen SW, Walker M
Journal: J Obstet Gynaecol Can
Antidepressants for smoking cessation.
Authors: Hughes J, Stead L, Lancaster T
Journal: Cochrane Database Syst Rev
Intrathecal tri-cyclic antidepressants produce spinal anesthesia.
Authors: Chen YW, Huang KL, Liu SY, Tzeng JI, Chu KS, Lin MT, Wang JJ
Journal: Pain
The role of metabolites in bioequivalence.
Authors: Midha KK, Rawson MJ, Hubbard JW
Journal: Pharm Res
Elevated quetiapine serum concentrations in a patient treated concomitantly with doxepin, lorazepam, and pantoprazole.
Authors: Härtter S, Connemann B, Schönfeldt-Lecuona C, Sachse J, Hiemke C
Journal: J Clin Psychopharmacol
'Hypnotic' prescription patterns in a large managed-care population.
Authors: Roehrs T, Roth T
Journal: Sleep Med
Inappropriate prescribing for elderly Americans in a large outpatient population.
Authors: Curtis LH, Østbye T, Sendersky V, Hutchison S, Dans PE, Wright A, Woosley RL, Schulman KA
Journal: Arch Intern Med
A comparison of side effects of selective serotonin reuptake inhibitors and tricyclic antidepressants in older depressed patients: a meta-analysis.
Authors: Wilson K, Mottram P
Journal: Int J Geriatr Psychiatry
Central effects of fexofenadine and cetirizine: measurement of psychomotor performance, subjective sleepiness, and brain histamine H1-receptor occupancy using 11C-doxepin positron emission tomography.
Authors: Tashiro M, Sakurada Y, Iwabuchi K, Mochizuki H, Kato M, Aoki M, Funaki Y, Itoh M, Iwata R, Wong DF, Yanai K
Journal: J Clin Pharmacol
Site 1 sodium channel blockers prolong the duration of sciatic nerve blockade from tricyclic antidepressants.
Authors: Barnet CS, Tse JY, Kohane DS
Journal: Pain
Decreased histamine H1 receptor binding in the brain of depressed patients.
Authors: Kano M, Fukudo S, Tashiro A, Utsumi A, Tamura D, Itoh M, Iwata R, Tashiro M, Mochizuki H, Funaki Y, Kato M, Hongo M, Yanai K
Journal: Eur J Neurosci
Topical application of the tricyclic antidepressant doxepin can reduce dysuria and frequency.
Authors: McCleane G
Journal: Scand J Urol Nephrol
Impact of polymorphisms of cytochrome-P450 isoenzymes 2C9, 2C19 and 2D6 on plasma concentrations and clinical effects of antidepressants in a naturalistic clinical setting.
Authors: Grasmäder K, Verwohlt PL, Rietschel M, Dragicevic A, Müller M, Hiemke C, Freymann N, Zobel A, Maier W, Rao ML
Journal: Eur J Clin Pharmacol
A comparative solid-phase extraction study for the simultaneous determination of fluvoxamine, mianserin, doxepin, citalopram, paroxetine, and etoperidone in whole blood by capillary gas-liquid chromatography with nitrogen-phosphorus detection.
Authors: Martínez MA, Sánchez de la Torre C, Almarza E
Journal: J Anal Toxicol
Glutathione S-transferase pi as a target for tricyclic antidepressants in human brain.
Authors: Bara?czyk-Ku?ma A, Ku?ma M, Gutowicz M, Ka?mierczak B, Sawicki J
Journal: Acta Biochim Pol
Evaluation of in vivo selective binding of [11C]doxepin to histamine H1 receptors in five animal species.
Authors: Ishiwata K, Kawamura K, Wang WF, Tsukada H, Harada N, Mochizuki H, Kimura Y, Ishii K, Iwata R, Yanai K
Journal: Nucl Med Biol
Impact of hydroxychloroquine therapy on chronic urticaria: chronic autoimmune urticaria study and evaluation.
Authors: Reeves GE, Boyle MJ, Bonfield J, Dobson P, Loewenthal M
Journal: Intern Med J
Are selective serotonin re-uptake inhibitors associated with an increased risk of self-harm by antidepressant overdose?
Authors: Bateman DN, Chick J, Good AM, Kelly CA, Masterton G
Journal: Eur J Clin Pharmacol
Severe adverse drug reactions of antidepressants: results of the German multicenter drug surveillance program AMSP.
Authors: Degner D, Grohmann R, Kropp S, Rüther E, Bender S, Engel RR, Schmidt LG
Journal: Pharmacopsychiatry
Psychotropic drug use in psychiatric inpatients: recent trends and changes over time-data from the AMSP study.
Authors: Grohmann R, Engel RR, Geissler KH, Rüther E
Journal: Pharmacopsychiatry
[Treatment of solar urticaria by intravenous immunoglobulins and PUVA therapy]
Authors: Darras S, Ségard M, Mortier L, Bonnevalle A, Thomas P
Journal: Ann Dermatol Venereol
National Patterns of Medication Treatment for Depression, 1987 to 2001.
Authors: Stafford RS, MacDonald EA, Finkelstein SN
Journal: Prim Care Companion J Clin Psychiatry
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