dna vaccines - Medical Dictionary

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dna vaccines		Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers. [ Books \| Images \| Discussion groups ]

Additional comments : (Naked DNA Vaccines, Nucleic Acid Vaccines, Polynucleotide Vaccines) Articles Immunogenicity of novel consensus-based DNA vaccines against Chikungunya virus. Authors: Muthumani K, Lankaraman KM, Laddy DJ, Sundaram SG, Chung CW, Sako E, Wu L, Khan A, Sardesai N, Kim JJ, Vijayachari P, Weiner DB Journal: Vaccine The first antibody responses to DNA vaccines in humans. Authors: Rottinghaus ST, Poland GA Journal: J Infect Dis Evaluation of the anti-tuberculosis activity generated by different multigene DNA vaccine constructs. Authors: Sali M, Clarizio S, Pusceddu C, Zumbo A, Pecorini G, Rocca S, Zanetti S, Delogu G, Fadda G Journal: Microbes Infect Increased immune responses in rhesus macaques by DNA vaccination combined with electroporation. Authors: Rosati M, Valentin A, Jalah R, Patel V, von Gegerfelt A, Bergamaschi C, Alicea C, Weiss D, Treece J, Pal R, Markham PD, Marques ET, August JT, Khan A, Draghia-Akli R, Felber BK, Pavlakis GN Journal: Vaccine Improved HIV-1 specific T-cell responses by short-interval DNA tattooing as compared to intramuscular immunization in non-human primates. Authors: Verstrepen BE, Bins AD, Rollier CS, Mooij P, Koopman G, Sheppard NC, Sattentau Q, Wagner R, Wolf H, Schumacher TN, Heeney JL, Haanen JB Journal: Vaccine DNA Vaccines 2008 - A marcus evans Forum Bridging the Gap Between Technology and Application. Authors: Ulmer JB Journal: IDrugs Mucosal immunity elicited by DNA vaccines. Authors: Jones T Journal: IDrugs [Effect of modified NDV F48E9 strain HN gene and in vitro expression of its DNA vaccine] Authors: He S, Shi X, Wang Y, Wang M, Ran D, Tong G Journal: Sheng Wu Gong Cheng Xue Bao Potentiation of an anthrax DNA vaccine with electroporation. Authors: Luxembourg A, Hannaman D, Nolan E, Ellefsen B, Nakamura G, Chau L, Tellez O, Little S, Bernard R Journal: Vaccine The ability of Hepatitis B surface antigen DNA vaccine to elicit cell-mediated immune responses, but not antibody responses, was affected by the deglysosylation of S antigen. Authors: Xing Y, Huang Z, Lin Y, Li J, Chou TH, Lu S, Wang S Journal: Vaccine DNA fusion vaccines incorporating IL-23 or RANTES for use in immunization against influenza. Authors: Williman J, Young S, Buchan G, Slobbe L, Wilson M, Pang P, Austyn J, Preston S, Baird M Journal: Vaccine Chemokine receptor-mediated delivery of mycobacterial MPT51 protein efficiently induces antigen-specific T-cell responses. Authors: Uchijima M, Nagata T, Koide Y Journal: Vaccine Enhancement of DNA Vaccine Potency through Coadministration of CIITA DNA with DNA Vaccines via Gene Gun. Authors: Kim D, Hoory T, Monie A, Ting JP, Hung CF, Wu TC Journal: J Immunol In vivo hierarchy of individual T-cell epitope-specific helper T-cell subset against an intracellular bacterium. Authors: Nagata T, Aoshi T, Uchijima M, Koide Y Journal: Vaccine Parameters for DNA vaccination using adaptive constant-current electroporation in mouse and pig models. Authors: Draghia-Akli R, Khan AS, Brown PA, Pope MA, Wu L, Hirao L, Weiner DB Journal: Vaccine Multifunctional T cell characteristics induced by a polyvalent DNA prime/protein boost HIV-1 vaccine regimen given to healthy adults are dependant upon the route and dose of administration. Authors: Bansal A, Jackson B, West K, Wang S, Lu S, Kennedy JS, Goepfert PA Journal: J Virol What happens to the DNA vaccine in fish? A review of current knowledge. Authors: Tonheim TC, Bøgwald J, Dalmo RA Journal: Fish Shellfish Immunol Various carrier system(s)- mediated genetic vaccination strategies against malaria. Authors: Tyagi RK, Sharma PK, Vyas SP, Mehta A Journal: Expert Rev Vaccines Immunogenicity of DNA Vaccines in Humans: It Takes Two to Tango. Authors: Lu S Journal: Hum Vaccin Novel linear DNA vaccines induce protective immune responses against lethal infection with influenza virus type A/H5N1. Authors: Kendirgi F, Yun NE, Linde NS, Zacks MA, Smith JN, Smith JK, McMicken H, Chen Y, Paessler S Journal: Hum Vaccin DNA vaccine therapy for Alzheimer's disease: present status and future direction. Authors: Okura Y, Matsumoto Y Journal: Rejuvenation Res Search for potential target site of nucleocapsid gene for the design of an epitope-based SARS DNA vaccine. Authors: Dutta NK, Mazumdar K, Lee BH, Baek MW, Kim DJ, Na YR, Park SH, Lee HK, Kariwa H, Mai LQ, Park JH Journal: Immunol Lett Antitumor activity of DNA vaccines based on the human papillomavirus-16 e7 protein genetically fused to a plant virus coat protein. Authors: Massa S, Simeone P, Muller A, Benvenuto E, Venuti A, Franconi R Journal: Hum Gene Ther Multi-antigenic DNA immunization using Herpes Simplex Virus type 2 genomic fragments. Authors: Braun RP, Dong L, Jerome S, Herber R, Roberts LK, Payne LG Journal: Hum Vaccin [Construction of DNA vaccines containing C3d-P29 against Newcastle disease] Authors: Chu X, Peng J, Weng L, Zhu R, Niu Z Journal: Wei Sheng Wu Xue Bao Combined effects of IL-12 and electroporation enhances the potency of DNA vaccination in macaques. Authors: Hirao LA, Wu L, Khan AS, Hokey DA, Yan J, Dai A, Betts MR, Draghia-Akli R, Weiner DB Journal: Vaccine DNA vaccination. Authors: Ulmer JB, Rappuoli R Journal: Curr Protoc Hum Genet DNA vaccines and their applications in veterinary practice: current perspectives. Authors: Dhama K, Mahendran M, Gupta PK, Rai A Journal: Vet Res Commun Single-round infectious particles enhance immunogenicity of a DNA vaccine against West Nile virus. Authors: Chang DC, Liu WJ, Anraku I, Clark DC, Pollitt CC, Suhrbier A, Hall RA, Khromykh AA Journal: Nat Biotechnol Chimeric vapA/groEL2 DNA vaccines enhance clearance of Rhodococcus equi in aerosol challenged C3H/He mice. Authors: Phumoonna T, Barton MD, Vanniasinkam T, Heuzenroeder MW Journal: Vaccine Food allergies and hypersensitivity: a review of pharmacotherapy and therapeutic strategies. Authors: Burks W, Kulis M, Pons L Journal: Expert Opin Pharmacother Immune responses induced by DNA vaccines encoding Newcastle virus haemagglutinin and/or fusion proteins in maternal antibody-positive commercial broiler chicken. Authors: Rajawat YS, Sundaresan NR, Ravindra PV, Kantaraja C, Ratta B, Sudhagar M, Rai A, Saxena VK, Palia SK, Tiwari AK Journal: Br Poult Sci Novel chemotactic-antigen DNA vaccine against cancer. Authors: Zhang S, Zhang Y Journal: Future Oncol The Leishmania HSP20 is antigenic during natural infections, but, as DNA vaccine, it does not protect BALB/c mice against experimental L. amazonensis infection. Authors: Montalvo-Alvarez AM, Folgueira C, Carrión J, Monzote-Fidalgo L, Cañavate C, Requena JM Journal: J Biomed Biotechnol Cluster intradermal DNA vaccination rapidly induces E7-specific CD8(+) T-cell immune responses leading to therapeutic antitumor effects. Authors: Peng S, Trimble C, Alvarez RD, Huh WK, Lin Z, Monie A, Hung CF, Wu TC Journal: Gene Ther Expression of interferon and interferon-induced genes in salmonids in response to virus infection, interferon-inducing compounds and vaccination. Authors: Robertsen B Journal: Fish Shellfish Immunol Enhancement of poly(orthoester) microspheres for DNA vaccine delivery by blending with poly(ethylenimine). Authors: Nguyen DN, Raghavan SS, Tashima LM, Lin EC, Fredette SJ, Langer RS, Wang C Journal: Biomaterials [Immunocontraceptive effect of DNA vaccines of Lagurus lagurus zona pellucida 3 fusioned with C-terminal of HSP70.] Authors: Zhang Y, Li YJ, Ma ZH, Chen X, Pan XY, Zhang FC Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi Induction of T cell-mediated immunity using a c-Myb DNA vaccine in a mouse model of colon cancer. Authors: Williams BB, Wall M, Miao RY, Williams B, Bertoncello I, Kershaw MH, Mantamadiotis T, Haber M, Norris MD, Gautam A, Darcy PK, Ramsay RG Journal: Cancer Immunol Immunother Skewing the T-cell repertoire by combined DNA vaccination, host conditioning, and adoptive transfer. Authors: Jorritsma A, Bins AD, Schumacher TN, Haanen JB Journal: Cancer Res The relative immunogenicity of DNA vaccines delivered by the intramuscular needle injection, electroporation and gene gun methods. Authors: Wang S, Zhang C, Zhang L, Li J, Huang Z, Lu S Journal: Vaccine Electroporation-mediated HBV DNA vaccination in primate models. Authors: Zhao YG, Xu Y Journal: Methods Mol Biol Construction of sperm-specific lactate dehydrogenase DNA vaccine and experimental study of its immunocontraceptive effect on mice. Authors: Chen Y, Zhang D, Xin N, Xiong Y, Chen P, Li B, Tu X, Lan F Journal: Sci China C Life Sci Anti-tumor immunity induced by CDR3-based DNA vaccination in a murine B-cell lymphoma model. Authors: Rinaldi M, Fioretti D, Iurescia S, Signori E, Pierimarchi P, Seripa D, Tonon G, Fazio VM Journal: Biochem Biophys Res Commun Oral DNA vaccines target the tumor vasculature and microenvironment and suppress tumor growth and metastasis. Authors: Xiang R, Luo Y, Niethammer AG, Reisfeld RA Journal: Immunol Rev DNA vaccination during TB treatment generates super-protective immunity. Authors: Lowrie DB Journal: Gene Ther PMMA particle-mediated DNA vaccine for cervical cancer. Authors: Lou PJ, Cheng WF, Chung YC, Cheng CY, Chiu LH, Young TH Journal: J Biomed Mater Res A Recruitment of Antigen-Presenting Cells to the Site of Inoculation and Augmentation of HIV-1 DNA Vaccine Immunogenicity by In Vivo Electroporation. Authors: Liu J, Kjeken R, Mathiesen I, Barouch DH Journal: J Virol DNA-based vaccines: the future of multiple sclerosis therapy? Authors: Stüve O, Cravens PD, Eagar TN Journal: Expert Rev Neurother Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria. Authors: Wells JM, Mercenier A Journal: Nat Rev Microbiol Intranasal delivery of DNA encoding antigens of Mycobacterium tuberculosis by non-pathogenic invasive Escherichia coli. Authors: Brun P, Zumbo A, Castagliuolo I, Delogu G, Manfrin F, Sali M, Fadda G, Grillot-Courvalin C, Palù G, Manganelli R Journal: Vaccine A novel DNA vaccine for protective immunity against virulent Mycobacterium bovis in mice. Authors: Liu S, Gong Q, Wang C, Liu H, Wang Y, Guo S, Wang W, Liu J, Shao M, Chi L, Zhao K, Wang Z, Shi Y, Huang Y, Guli A, Zhang C, Kong X Journal: Immunol Lett Augmentation of SIV DNA vaccine-induced cellular immunity by targeting the 4-1BB costimulatory molecule. Authors: Calarota SA, Hokey DA, Dai A, Jure-Kunkel MN, Balimane P, Weiner DB Journal: Vaccine Vaccine-elicited 10-kilodalton culture filtrate protein-specific CD8+ T cells are sufficient to mediate protection against Mycobacterium tuberculosis infection. Authors: Wu Y, Woodworth JS, Shin DS, Morris S, Behar SM Journal: Infect Immun IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection. Authors: Brooks DG, Lee AM, Elsaesser H, McGavern DB, Oldstone MB Journal: J Exp Med Protective effect of a multiantigenic DNA vaccine against Toxoplasma gondii with co-delivery of IL-12 in mice. Authors: Cui YL, He SY, Xue MF, Zhang J, Wang HX, Yao Y Journal: Parasite Immunol Enhancement of HIV DNA vaccine immunogenicity by the NKT cell ligand, alpha-galactosylceramide. Authors: Huang Y, Chen A, Li X, Chen Z, Zhang W, Song Y, Gurner D, Gardiner D, Basu S, Ho DD, Tsuji M Journal: Vaccine HIV-1 Env vaccine comprised of electroporated DNA and protein co-administered with Talabostat. Authors: Cristillo AD, Galmin L, Restrepo S, Hudacik L, Suschak J, Lewis B, Draghia-Akli R, Aziz N, Weiss D, Markham P, Pal R Journal: Biochem Biophys Res Commun Enhancement of the immunogenicity of an infectious bronchitis virus DNA vaccine by a bicistronic plasmid encoding nucleocapsid protein and interleukin-2. Authors: Tang M, Wang H, Zhou S, Tian G Journal: J Virol Methods [Expression and immunity of fused protein H1N1 M2e and cholera toxin B.] Authors: Yang XF, Jiang Y, Li WY, Kuang Y, Jiang ZH, Wang FP, Li MY Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi A review of the epidemiology, prevention and treatment of human immunodeficiency virus infection in Nigeria. Authors: Entonu PE, Agwale SM Journal: Braz J Infect Dis Pandemic H5N1 influenza vaccine development: an update. Authors: El Sahly HM, Keitel WA Journal: Expert Rev Vaccines Current progress of DNA vaccine studies in humans. Authors: Lu S, Wang S, Grimes-Serrano JM Journal: Expert Rev Vaccines The efficacy of DNA vaccination is enhanced in mice by targeting the encoded protein to dendritic cells. Authors: Nchinda G, Kuroiwa J, Oks M, Trumpfheller C, Park CG, Huang Y, Hannaman D, Schlesinger SJ, Mizenina O, Nussenzweig MC, Uberla K, Steinman RM Journal: J Clin Invest Dramatic improvement in FMD DNA vaccine efficacy and cross-serotype antibody induction in pigs following a protein boost. Authors: Li Y, Stirling CM, Denyer MS, Hamblin P, Hutchings G, Takamatsu HH, Barnett PV Journal: Vaccine Emerging vaccines for influenza. Authors: Tosh PK, Poland GA Journal: Expert Opin Emerg Drugs [Study on the DNA immunogenicity of fusion and attachment glycoproteins of Nipah virus] Authors: Wang XJ, Ge JY, Wang QH, Hu S, Lin XM, Bu ZG Journal: Bing Du Xue Bao [Construction and immunogenicity of attenuated Salmonella typhimurium stably harbouring DNA vaccine against Newcastle disease virus] Authors: Pan ZM, Huang JL, Cheng NN, Cui YC, You M, Tang LH, Zhang XM, Jiao XA, Liu XF Journal: Bing Du Xue Bao WHO Expert Committee on biological standardization. Authors: Journal: World Health Organ Tech Rep Ser Immunogenicity and efficacy of a DNA vaccine in aged mice. Authors: Klinman DM, Conover J, Bloom ET, Weiss W Journal: J Gerontol A Biol Sci Med Sci Delivery of DNA HIV-1 vaccine to the liver induces high and long-lasting humoral immune responses. Authors: Raska M, Moldoveanu Z, Novak J, Hel Z, Novak L, Bozja J, Compans RW, Yang C, Mestecky J Journal: Vaccine CD44 gene vaccination for insulin-dependent diabetes mellitus in non-obese diabetic mice. Authors: Weiss L, Botero-Anug AM, Hand C, Slavin S, Naor D Journal: Isr Med Assoc J [Updated application of prostate-specific membrane antigen to the diagnosis and treatment of prostate cancer] Authors: Tang QL, Yao MY Journal: Zhonghua Nan Ke Xue Vaccines for leishmaniasis in the fore coming 25 years. Authors: Palatnik-de-Sousa CB Journal: Vaccine The role of vaccine therapy in the treatment of melanoma. Authors: Lens M Journal: Expert Opin Biol Ther Relative immunogenicity and protection potential of candidate Yersinia Pestis antigens against lethal mucosal plague challenge in Balb/C mice. Authors: Wang S, Joshi S, Mboudjeka I, Liu F, Ling T, Goguen JD, Lu S Journal: Vaccine Dose-dependent protection against or exacerbation of disease by a polylactide glycolide microparticle-adsorbed, alphavirus-based measles virus DNA vaccine in rhesus macaques. Authors: Pan CH, Nair N, Adams RJ, Zink MC, Lee EY, Polack FP, Singh M, O'Hagan DT, Griffin DE Journal: Clin Vaccine Immunol A comparative study of gene vaccines encoding different extracellular domains of the Vascular Endothelial Growth Factor Receptor 2 in the mouse model of colon adenocarcinoma CT-26. Authors: Dong J, Yang J, Ming Chen Q, Xi Wang C, Zhi Wu P, Chen Y, Zhi Wang Q, Li M Journal: Cancer Biol Ther Enhancement of antibody responses to Bacillus anthracis protective antigen domain IV by use of calreticulin as a chimeric molecular adjuvant. Authors: Park YS, Lee JH, Hung CF, Wu TC, Kim TW Journal: Infect Immun Targeting tumor antigens to secreted membrane vesicles in vivo induces efficient antitumor immune responses. Authors: Zeelenberg IS, Ostrowski M, Krumeich S, Bobrie A, Jancic C, Boissonnas A, Delcayre A, Le Pecq JB, Combadière B, Amigorena S, Théry C Journal: Cancer Res A continuous process to extract plasmid DNA based on alkaline lysis. Authors: Li X, Jin H, Wu Z, Rayner S, Wang B Journal: Nat Protoc The "A, B and C" of Her-2 DNA vaccine development. Authors: Wei WZ, Jacob J, Radkevich-Brown O, Whittington P, Kong YC Journal: Cancer Immunol Immunother Role of IL-2 secreted by PADRE-specific CD4+ T cells in enhancing E7-specific CD8+ T-cell immune responses. Authors: Kim D, Monie A, He L, Tsai YC, Hung CF, Wu TC Journal: Gene Ther A recombinant plasmid co-expressing swine ubiquitin and the GP5 encoding-gene of porcine reproductive and respiratory syndrome virus induces protective immunity in piglets. Authors: Hou YH, Chen J, Tong GZ, Tian ZJ, Zhou YJ, Li GX, Li X, Peng JM, An TQ, Yang HC Journal: Vaccine [Effects of house dust mite allergen DNA vaccines on the allergic airway inflammation in murine models] Authors: Bi YT, Wu K, Wang Y, Zhuo WL, Wang CZ, Qian GS Journal: Zhonghua Nei Ke Za Zhi [Designing an effective AIDS vaccine: Strategies and current status.] Authors: Coutsinos Z, Absi Z, Henin Y, Guillet JG, Launay O Journal: Rev Med Interne DNA-vaccination via tattooing induces stronger humoral and cellular immune responses than intramuscular delivery supported by molecular adjuvants. Authors: Pokorna D, Rubio I, Müller M Journal: Genet Vaccines Ther TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Authors: Ishii KJ, Kawagoe T, Koyama S, Matsui K, Kumar H, Kawai T, Uematsu S, Takeuchi O, Takeshita F, Coban C, Akira S Journal: Nature Transitory or long-lasting immunity to Leishmania major infection: the result of immunogenicity and multicomponent properties of histone DNA vaccines. Authors: Carrión J, Folgueira C, Alonso C Journal: Vaccine [The immunocontraceptive effects of Lagurus lagurus and Mus musculus zona pellucida 3 DNA vaccine] Authors: Zhang Y, Li YJ, Liu F, Chen R, Guo JH, Zhang FC Journal: Fen Zi Xi Bao Sheng Wu Xue Bao Optimized DNA vaccines to specifically induce therapeutic CD8 T cell responses against autochthonous breast tumors. Authors: Cho HI, Niu G, Bradley N, Celis E Journal: Cancer Immunol Immunother Novel vaccination protocol with two live mucosal vectors elicits strong cell-mediated immunity in the vagina and protects against vaginal virus challenge. Authors: Li Z, Zhang M, Zhou C, Zhao X, Iijima N, Frankel FR Journal: J Immunol Effects of IL-7 on memory CD8 T cell homeostasis are influenced by the timing of therapy in mice. Authors: Nanjappa SG, Walent JH, Morre M, Suresh M Journal: J Clin Invest Prostate stem cell antigen vaccination induces a long-term protective immune response against prostate cancer in the absence of autoimmunity. Authors: Garcia-Hernandez Mde L, Gray A, Hubby B, Klinger OJ, Kast WM Journal: Cancer Res Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers. Authors: Wang S, Kennedy JS, West K, Montefiori DC, Coley S, Lawrence J, Shen S, Green S, Rothman AL, Ennis FA, Arthos J, Pal R, Markham P, Lu S Journal: Vaccine Comparative studies on in vitro expression and in vivo immunogenicity of supercoiled and open circular forms of plasmid DNA vaccines. Authors: Pillai VB, Hellerstein M, Yu T, Amara RR, Robinson HL Journal: Vaccine A multigene HIV type 1 subtype C modified vaccinia Ankara (MVA) vaccine efficiently boosts immune responses to a DNA vaccine in mice. Authors: Shephard E, Burgers WA, Van Harmelen JH, Monroe JE, Greenhalgh T, Williamson C, Williamson AL Journal: AIDS Res Hum Retroviruses Construction, characterization, and immunogenicity of a multigene modified vaccinia Ankara (MVA) vaccine based on HIV type 1 subtype C. Authors: Burgers WA, Shephard E, Monroe JE, Greenhalgh T, Binder A, Hurter E, Van Harmelen JH, Williamson C, Williamson AL Journal: AIDS Res Hum Retroviruses [Immunogenicity of DNA vaccine prime-BCG boost against Mycobacterium tuberculosis.] Authors: Gao L, Bao L, Hao M, Zhang HD Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi Tumor endothelial marker 8 enhances tumor immunity in conjunction with immunization against differentiation Ag. Authors: Felicetti P, Mennecozzi M, Barucca A, Montgomery S, Orlandi F, Manova K, Houghton AN, Gregor PD, Concetti A, Venanzi FM Journal: Cytotherapy

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