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| disulfiram |
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A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
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Additional comments :
(Tetraethylthiuram Disulfide, Alcophobin, Antabuse, Anticol, Dicupral, Esperal, Refusal, Teturam)
Articles
 [Compensatory effect of the selank on the mnestic functions disturbed by neurotoxic damage of the noradrenergic system of rat brain]
Authors:
Journal: Eksp Klin Farmakol
New uses for old copper-binding drugs: converting the pro-angiogenic copper to a specific cancer cell death inducer.
Authors: Chen D, Dou QP
Journal: Expert Opin Ther Targets
Disulfiram enhances subjective effects of dextroamphetamine in humans.
Authors: Sofuoglu M, Poling J, Waters A, Sewell A, Hill K, Kosten T
Journal: Pharmacol Biochem Behav
Ritonavir and disulfiram may be synergistic in lowering active interleukin-18 levels in acute pancreatitis, and thereby hasten recovery.
Authors: Kast RE
Journal: JOP
Effect of disulfiram eye drops on lipid peroxide formation via excessive nitric oxide in lenses of hereditary cataract ICR/f rats.
Authors: Nagai N, Ito Y, Takeuchi N
Journal: Biol Pharm Bull
Tolerance to Disulfiram Induced by Chronic Alcohol Intake in the Rat.
Authors: Tampier L, Quintanilla ME, Israel Y
Journal: Alcohol Clin Exp Res
[Pharmacological review of alcoholic dependence treatment.]
Authors: Oural L, Paris MV, Sullivan O, Polach M, Pavlovsky F, Capece J
Journal: Vertex
[Pharmacology of disulfiram - an update]
Authors: Mutschler J, Diehl A, Kiefer F
Journal: Fortschr Neurol Psychiatr
Potantial utility of disulfiram against leishmaniasis.
Authors: Namazi MR
Journal: Indian J Med Res
Inhibitive effects of enhanced lipid peroxidation on Ca(2+)-ATPase in lenses of hereditary cataract ICR/f rats.
Authors: Nagai N, Ito Y, Takeuchi N
Journal: Toxicology
Disulfiram neuropathy: Two cases of distal axonopathy.
Authors: Filosto M, Tentorio M, Broglio L, Buzio S, Lazzarini C, Pasolini MP, Cotelli MS, Scarpelli M, Mancuso M, Choub A, Padovani A
Journal: Clin Toxicol (Phila)
Comment on "Disulfiram-like effect of cyproterone acetate" [Z. Nitzan, M. Dan, Eur. J. Obstet. Gynecol. Reprod. Biol. (2007)].
Authors: Karamanakos PN, Pappas P, Marselos M
Journal: Eur J Obstet Gynecol Reprod Biol
Effects of disulfiram and dopamine beta-hydroxylase knockout on cocaine-induced seizures.
Authors: Gaval-Cruz M, Schroeder JP, Liles LC, Javors MA, Weinshenker D
Journal: Pharmacol Biochem Behav
Disulfiram promotes the conversion of carcinogenic cadmium to a proteasome inhibitor with pro-apoptotic activity in human cancer cells.
Authors: Li L, Yang H, Chen D, Cui C, Ping Dou Q
Journal: Toxicol Appl Pharmacol
[Is disulfiram (Antabus) indicated in the treatment of offenders with alcohol use disorders?]
Authors: Stolpmann G, Müller J
Journal: Psychiatr Prax
[Alcohol dependence: diagnosis and treatment]
Authors: Perney P, Rigole H, Blanc F
Journal: Rev Med Interne
[Unhealthy alcohol use in the elderly--current screening and treatment strategies]
Authors: Lieb B, Rosien M, Bonnet U, Scherbaum N
Journal: Fortschr Neurol Psychiatr
Measurement of direct ethanol metabolites in a case of a former driving under the influence (DUI) of alcohol offender, now claiming abstinence.
Authors: Wurst FM, Yegles M, Alling C, Aradottir S, Dierkes J, Wiesbeck GA, Halter CC, Pragst F, Auwaerter V
Journal: Int J Legal Med
In vitro gene expression analysis of hepatotoxic drugs in rat primary hepatocytes.
Authors: Suzuki H, Inoue T, Matsushita T, Kobayashi K, Horii I, Hirabayashi Y, Inoue T
Journal: J Appl Toxicol
In vitro cell culture model for anti-cataract drug penetration studies.
Authors: Jiang TY, Wang SL, Liu Y, Nie SF, Ito Y, Nagai N, Wu CF
Journal: Pharmazie
Uses of coercion in addiction treatment: clinical aspects.
Authors: Sullivan MA, Birkmayer F, Boyarsky BK, Frances RJ, Fromson JA, Galanter M, Levin FR, Lewis C, Nace EP, Suchinsky RT, Tamerin JS, Tolliver B, Westermeyer J
Journal: Am J Addict
Activation of TRPA1 by farnesyl thiosalicylic acid.
Authors: Maher M, Ao H, Banke T, Nasser N, Wu NT, Breitenbucher JG, Chaplan SR, Wickenden AD
Journal: Mol Pharmacol
[Current pharmacotherapies and immunotherapy in cocaine addiction]
Authors: Karila L, Weinstein A, Benyamina A, Coscas S, Leroy C, Noble F, Lowenstein W, Aubin HJ, Lépine JP, Reynaud M
Journal: Presse Med
Disulfiram-like effect of cyproterone acetate.
Authors: Nitzan Z, Dan M
Journal: Eur J Obstet Gynecol Reprod Biol
Norepinephrine signaling through beta-adrenergic receptors is critical for expression of cocaine-induced anxiety.
Authors: Schank JR, Liles LC, Weinshenker D
Journal: Biol Psychiatry
A double blind, placebo-controlled trial that combines disulfiram and naltrexone for treating co-occurring cocaine and alcohol dependence.
Authors: Pettinati HM, Kampman KM, Lynch KG, Xie H, Dackis C, Rabinowitz AR, O Brien CP
Journal: Addict Behav
The impact of personality disorders on alcohol-use outcomes in a pharmacotherapy trial for alcohol dependence and comorbid Axis I disorders.
Authors: Ralevski E, Ball S, Nich C, Limoncelli D, Petrakis I
Journal: Am J Addict
New therapies for alcohol dependence open options for office-based treatment.
Authors: Kuehn BM
Journal: JAMA
Apoptosis of cultured astrocytes induced by the copper and neocuproine complex through oxidative stress and JNK activation.
Authors: Chen SH, Lin JK, Liu SH, Liang YC, Lin-Shiau SY
Journal: Toxicol Sci
Disulfiram suppresses invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression.
Authors: Cho HJ, Lee TS, Park JB, Park KK, Choe JY, Sin DI, Park YY, Moon YS, Lee KG, Yeo JH, Han SM, Cho YS, Choi MR, Park NG, Lee YS, Chang YC
Journal: J Biochem Mol Biol
[Mushroom poisonings: syndromic diagnosis and treatment]
Authors: Kaufmann P
Journal: Wien Med Wochenschr
Evaluation of the effect of ethanol's toxic metabolite acetaldehyde on the gastrointestinal oligopeptide transporter, PEPT1: in vitro and in vivo studies.
Authors: Fisher SJ, Lee IJ, Swaan PW, Eddington ND
Journal: Alcohol Clin Exp Res
Acute Vocal Cord Palsy After Acute Disulfiram Intoxication.
Authors: Bae JS
Journal: J Voice
Immunolocalization of vascularization factors in normal, tibial dyschondroplasia and rachitic cartilage.
Authors: Gay CV, Gilman VR, Leach RM
Journal: Avian Pathol
Evaluation of copper-dependent proteasome-inhibitory and apoptosis-inducing activities of novel pyrrolidine dithiocarbamate analogues.
Authors: Yu Z, Wang F, Milacic V, Li X, Cui QC, Zhang B, Yan B, Dou QP
Journal: Int J Mol Med
Pueraria lobata (Kudzu root) hangover remedies and acetaldehyde-associated neoplasm risk.
Authors: McGregor NR
Journal: Alcohol
Complex, unusual conformational changes in kidney betaine aldehyde dehydrogenase suggested by chemical modification with disulfiram.
Authors: Ayala-Castro HG, Valenzuela-Soto EM, Figueroa-Soto CG, Muñoz-Clares RA
Journal: Arch Biochem Biophys
A case of disulfiram-methylphenidate interaction: implications for treatment.
Authors: Caci H, Baylé F
Journal: Am J Psychiatry
A randomized, multicentre, open-label, comparative trial of disulfiram, naltrexone and acamprosate in the treatment of alcohol dependence.
Authors: Laaksonen E, Koski-Jännes A, Salaspuro M, Ahtinen H, Alho H
Journal: Alcohol Alcohol
Pharmaceutical agents known to produce disulfiram-like reaction: effects on hepatic ethanol metabolism and brain monoamines.
Authors: Karamanakos PN, Pappas P, Boumba VA, Thomas C, Malamas M, Vougiouklakis T, Marselos M
Journal: Int J Toxicol
Adverse effects of excessive nitric oxide on cytochrome c oxidase in lenses of hereditary cataract UPL rats.
Authors: Nagai N, Ito Y
Journal: Toxicology
New treatments for cocaine dependence: a focused review.
Authors: Karila L, Gorelick D, Weinstein A, Noble F, Benyamina A, Coscas S, Blecha L, Lowenstein W, Martinot JL, Reynaud M, Lépine JP
Journal: Int J Neuropsychopharmacol
[Acute encephalopathy secondary to treatment with disulfiram]
Authors: Zarza B, Martínez-Castrillo JC, Luque M, Masjuán-Vallejo J
Journal: Rev Neurol
Drug interactions involving ethanol and alcoholic beverages.
Authors: Jang GR, Harris RZ
Journal: Expert Opin Drug Metab Toxicol
Manic episode with psychosis following a lower than recommended dosage regimen of disulfiram.
Authors: Li MY, Shen YC
Journal: Prog Neuropsychopharmacol Biol Psychiatry
Update on neuropharmacological treatments for alcoholism: scientific basis and clinical findings.
Authors: Johnson BA
Journal: Biochem Pharmacol
Compliance with aftercare treatment, including disulfiram, and effect on outcome in alcohol-dependent patients.
Authors: Neto D, Lambaz R, Tavares JE
Journal: Alcohol Alcohol
Personality disorders among danish alcoholics attending outpatient treatment.
Authors: Nordholm D, Nielsen B
Journal: Eur Addict Res
Disulfiram-induced transient optic and peripheral neuropathy: a case report.
Authors: Orakzai A, Guerin M, Beatty S
Journal: Ir J Med Sci
The psychiatric management of patients with alcohol dependence.
Authors: Ritvo JI, Park C
Journal: Curr Treat Options Neurol
Are disulfiram-like reactions associated with abacavir-containing antiretroviral regimens in clinical practice?
Authors: Barber TJ, Marett B, Waldron S, Portsmouth S, Mackie NE, Weston R, Winston A
Journal: AIDS
Perturbation of retinoic acid (RA)-mediated limb development suggests a role for diminished RA signaling in the teratogenesis of ethanol.
Authors: Johnson CS, Zucker RM, Hunter ES, Sulik KK
Journal: Birth Defects Res A Clin Mol Teratol
Antifungal potential of disulfiram.
Authors: Khan S, Singhal S, Mathur T, Upadhyay DJ, Rattan A
Journal: Nippon Ishinkin Gakkai Zasshi
Delay in ICR/f rat lens opacification by the instillation of eye drops containing disulfiram and hydroxypropyl-beta-cyclodextrin inclusion complex.
Authors: Nagai N, Takeda M, Ito Y, Takeuchi N, Kamei A
Journal: Biol Pharm Bull
Dermatitis recall during disulfiram therapy.
Authors: Zawar V, Nerlikar S
Journal: Indian J Dermatol Venereol Leprol
Disulfiram in context: structure and safety.
Authors: Martin B, Beresford TP
Journal: J Clin Psychopharmacol
An open randomized trial comparing disulfiram and topiramate in the treatment of alcohol dependence.
Authors: De Sousa AA, De Sousa J, Kapoor H
Journal: J Subst Abuse Treat
Induction of tibial dyschondroplasia by carbamate and thiocarbamate pesticides.
Authors: Rath NC, Huff WE, Huff GR, Kannan L
Journal: Avian Dis
Hypotension and ST depression as a result of disulfiram ethanol reaction.
Authors: Milne HJ, Parke TR
Journal: Eur J Emerg Med
[Pharmacotherapy of schizophrenia and comorbid substance use disorder. A systematic review]
Authors: Wobrock T, D'Amelio R, Falkai P
Journal: Nervenarzt
Risks of combined alcohol/medication use in older adults.
Authors: Moore AA, Whiteman EJ, Ward KT
Journal: Am J Geriatr Pharmacother
Disulfiram is an inhibitor of human purified monoacylglycerol lipase, the enzyme regulating 2-arachidonoylglycerol signaling.
Authors: Labar G, Bauvois C, Muccioli GG, Wouters J, Lambert DM
Journal: Chembiochem
Disulfiram inhibits defluorination of (18)F-FCWAY, reduces bone radioactivity, and enhances visualization of radioligand binding to serotonin 5-HT1A receptors in human brain.
Authors: Ryu YH, Liow JS, Zoghbi S, Fujita M, Collins J, Tipre D, Sangare J, Hong J, Pike VW, Innis RB
Journal: J Nucl Med
Substance abuse and schizophrenia: pharmacotherapeutic intervention.
Authors: Green AI, Noordsy DL, Brunette MF, O'Keefe C
Journal: J Subst Abuse Treat
The impact of eosinophilia and hepatic necrosis on prognosis in patients with drug-induced liver injury.
Authors: Björnsson E, Kalaitzakis E, Olsson R
Journal: Aliment Pharmacol Ther
Effects of dissolved carbonates and carboxylates on the sorption of thiuram disulfide pesticides on humic acids and model surfaces.
Authors: Stathi P, Louloudi M, Deligiannakis Y
Journal: Environ Sci Technol
Prescription procedures in medication for relapse prevention after inpatient treatment for alcohol use disorders in Switzerland.
Authors: Buri C, Moggi F, Giovanoli A, Strik W
Journal: Alcohol Alcohol
New developments in the pharmacotherapy of cocaine abuse.
Authors: Preti A
Journal: Addict Biol
Availability of addiction medications in private health plans.
Authors: Horgan CM, Reif S, Hodgkin D, Garnick DW, Merrick EL
Journal: J Subst Abuse Treat
Re: Severe toxic hepatitis.
Authors: Pinillos H, Holt PR, Thung S
Journal: Dig Dis Sci
Manic episode with psychotic symptoms associated with high dose of disulfiram: a case report.
Authors: Ceylan ME, Turkcan A, Mutlu E, Onal O
Journal: J Clin Psychopharmacol
Naltrexone and disulfiram in patients with alcohol dependence and current depression.
Authors: Petrakis I, Ralevski E, Nich C, Levinson C, Carroll K, Poling J, Rounsaville B,
Journal: J Clin Psychopharmacol
Treatment retention and outcome among cocaine-dependent patients with and without active criminal justice involvement.
Authors: Easton CJ, Babuscio T, Carroll KM
Journal: J Am Acad Psychiatry Law
Problem drinking in relation to treatment outcome among opiate addicts in methadone maintenance treatment.
Authors: Stenbacka M, Beck O, Leifman A, Romelsjö A, Helander A
Journal: Drug Alcohol Rev
Pharmacotherapy of dual substance abuse and dependence.
Authors: Kenna GA, Nielsen DM, Mello P, Schiesl A, Swift RM
Journal: CNS Drugs
Schizophrenia and co-occurring substance use disorder.
Authors: Green AI, Drake RE, Brunette MF, Noordsy DL
Journal: Am J Psychiatry
Peripheral nerve protein expression and carbonyl content in N,N-diethlydithiocarbamate myelinopathy.
Authors: Viquez OM, Valentine HL, Friedman DB, Olson SJ, Valentine WM
Journal: Chem Res Toxicol
Alcohol withdrawal syndrome: how to predict, prevent, diagnose and treat it.
Authors:
Journal: Prescrire Int
Alcohol dependence and pharmacologic treatment. Introduction.
Authors: McDonough KP
Journal: Am J Health Syst Pharm
Improving adherence in patients with alcohol dependence: a new role for pharmacists.
Authors: Peterson AM
Journal: Am J Health Syst Pharm
Emerging approaches to managing alcohol dependence.
Authors: Swift R
Journal: Am J Health Syst Pharm
[Disulfiram-induced delirium: a case report]
Authors: Iwashige T, Shibasaki M
Journal: Nihon Arukoru Yakubutsu Igakkai Zasshi
Comparison of ivermectin and benzyl benzoate lotion for scabies in Nigerian patients.
Authors: Sule HM, Thacher TD
Journal: Am J Trop Med Hyg
Acetaminophen potentiates staurosporine-induced death in a human neuroblastoma cell line.
Authors: Posadas I, Vellecco V, Santos P, Prieto-Lloret J, Ceña V
Journal: Br J Pharmacol
Preclinical and clinical pharmacology of alcohol dependence.
Authors: Tambour S, Quertemont E
Journal: Fundam Clin Pharmacol
Refractive hypotension in a patient with disulfiram-ethanol reaction.
Authors: Ho MP, Yo CH, Liu CM, Chen CL, Lee CC
Journal: Am J Med Sci
Image-based screening for the identification of novel proteasome inhibitors.
Authors: Rickardson L, Wickström M, Larsson R, Lövborg H
Journal: J Biomol Screen
Short-term efficacy of Disulfiram or Naltrexone in reducing positive urinalysis for both cocaine and cocaethylene in cocaine abusers: a pilot study.
Authors: Grassi MC, Cioce AM, Giudici FD, Antonilli L, Nencini P
Journal: Pharmacol Res
[Drugs against alcohol abuse]
Authors: Mørland J
Journal: Tidsskr Nor Laegeforen
Comparing treatments of alcoholism on craving and biochemical measures of alcohol consumptionst.
Authors: Nava F, Premi S, Manzato E, Lucchini A
Journal: J Psychoactive Drugs
There and back again: a tale of norepinephrine and drug addiction.
Authors: Weinshenker D, Schroeder JP
Journal: Neuropsychopharmacology
Axonal retraction and regeneration induced by N,N-diethyldithiocarbamate (DEDTC) in the central nervous system.
Authors: Junyent F, Utrera J, Auladell C
Journal: Eur J Neurosci
A breath test to assess compliance with disulfiram.
Authors: Fletcher K, Stone E, Mohamad MW, Faulder GC, Faulder RM, Jones K, Morgan D, Wegerdt J, Kelly M, Chick J
Journal: Addiction
[Wernicke's encephalopathy associated with chronic disulfiram intoxication]
Authors: Charles V, Boulvin S, Haven F, Gille M
Journal: Rev Neurol (Paris)
[Pharmacological relapse prevention in alcohol and tobacco dependence]
Authors: Diehl A, Mann K
Journal: Internist (Berl)
Acute myocardial infarction due to disulfiram (antabus)-alcohol interaction.
Authors: Altun G, Altun A, Erdogan O
Journal: Cardiovasc Drugs Ther
Combining psychosocial treatment with pharmacotherapy for alcohol dependence.
Authors: Weiss RD, Kueppenbender KD
Journal: J Clin Psychopharmacol
Trends in the adoption of medications for alcohol dependence.
Authors: Ducharme LJ, Knudsen HK, Roman PM
Journal: J Clin Psychopharmacol
New pharmacological approaches for the treatment of alcoholism.
Authors: Soyka M, Roesner S
Journal: Expert Opin Pharmacother
Management of comorbid bipolar disorder and substance abuse.
Authors: Brown ES
Journal: J Clin Psychiatry
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