dextromethorphan - Medical Dictionary

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dextromethorphan		The d-isomer of the codeine analog of levorphanol. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity. [ Books \| Images \| Discussion groups ]

Additional comments : (d-Methorphan, Delsym, Dextromethorphan Hydrobromide, Benylin DM, Creo-Terpin, Drixoral, Trocal) Articles Developmental Changes in Human Liver CYP2D6 Expression. Authors: Stevens JC, Marsh SA, Zaya MJ, Regina KJ, Le M, Hines RN Journal: Drug Metab Dispos Dextromethorphan and quinidine combination for heroin detoxification. Authors: Akerele E, Bisaga A, Sullivan MA, Garawi F, Comer SD, Thomas AA, Nunes EV, Kleber HD Journal: Am J Addict Metabolite profiling in human urine by LC-MS/MS: Method optimization and application for glucuronides from dextromethorphan metabolism. Authors: Lutz U, Bittner N, Lutz RW, Lutz WK Journal: J Chromatogr B Analyt Technol Biomed Life Sci Social reward-conditioned place preference: A model revealing an interaction between cocaine and social context rewards in rats. Authors: Thiel KJ, Okun AC, Neisewander JL Journal: Drug Alcohol Depend Effect of dextromethorphan on antinociception and tolerance induced by swim-stress in the formalin test. Authors: Fazli-Tabaei S, Maghsoudi A, Bazaz N, Modirzadeh A, Zarrindast MR Journal: Arch Iran Med An update on the pharmacological management of post-herpetic neuralgia and painful diabetic neuropathy. Authors: Zin CS, Nissen LM, Smith MT, O'Callaghan JP, Moore BJ Journal: CNS Drugs Development and validation of ELISA and GC-MS procedures for the quantification of dextromethorphan and its main metabolite dextrorphan in urine and oral fluid. Authors: Rodrigues WC, Wang G, Moore C, Agrawal A, Vincent MJ, Soares JR Journal: J Anal Toxicol Evaluation of HepaRG Cells as an In Vitro Model for Human Drug Metabolism Studies. Authors: Kanebratt KP, Andersson TB Journal: Drug Metab Dispos Role of endogenous sleep-wake and analgesic systems in anesthesia. Authors: Lu J, Nelson LE, Franks N, Maze M, Chamberlin NL, Saper CB Journal: J Comp Neurol Pharmacokinetic effect of AMD070, an Oral CXCR4 antagonist, on CYP3A4 and CYP2D6 substrates midazolam and dextromethorphan in healthy volunteers. Authors: Nyunt MM, Becker S, MacFarland RT, Chee P, Scarborough R, Everts S, Calandra GB, Hendrix CW Journal: J Acquir Immune Defic Syndr Life-Threatening Dextromethorphan Intoxication Associated with Interaction with Amitriptyline in a Poor CYP2D6 Metabolizer: A Single Case Re-exposure Study. Authors: Forget P, le Polain de Waroux B, Wallemacq P, Gala JL Journal: J Pain Symptom Manage Changes in maternal liver Cyp2c and Cyp2d expression and activity during rat pregnancy. Authors: Dickmann LJ, Tay S, Senn TD, Zhang H, Visone A, Unadkat JD, Hebert MF, Isoherranen N Journal: Biochem Pharmacol Brain levels of dextromethorphan and the intensity of opioid withdrawal in mice. Authors: Bisaga A, Kos T, Wójcikowski J, Daniel WA, Popik P Journal: Drug Alcohol Depend Isobolographic analysis of epinephrine with bupivacaine, dextromethorphan, 3-methoxymorphinan, or dextrorphan on infiltrative anesthesia in rats: dose-response studies. Authors: Chen YW, Liu KS, Wang JJ, Chou W, Hung CH Journal: Reg Anesth Pain Med Lack of interaction of the NMDA receptor antagonists dextromethorphan and dextrorphan with P-glycoprotein. Authors: Kanaan M, Daali Y, Dayer P, Desmeules J Journal: Curr Drug Metab Sigma ligands, but not N-methyl-D-aspartate antagonists, reduce levodopa-induced dyskinesias. Authors: Paquette MA, Brudney EG, Putterman DB, Meshul CK, Johnson SW, Berger SP Journal: Neuroreport Assessment of antitussive efficacy of dextromethorphan in smoking related cough: objective vs. subjective measures. Authors: Ramsay J, Wright C, Thompson R, Hull D, Morice AH Journal: Br J Clin Pharmacol Dextromethorphan is protective against sensitized N-methyl-D-aspartate receptor-mediated excitotoxic brain damage in the developing mouse brain. Authors: Keller M, Griesmaier E, Auer M, Schlager G, Urbanek M, Simbruner G, Gressens P, Sárközy G Journal: Eur J Neurosci Sex differences in NMDA antagonist enhancement of morphine antihyperalgesia in a capsaicin model of persistent pain: comparisons to two models of acute pain. Authors: Lomas LM, Terner JM, Picker MJ Journal: Pharmacol Biochem Behav Effect of the NMDA-receptor antagonist dextromethorphan in infant rat pneumococcal meningitis. Authors: Sellner J, Ringer R, Baumann P, Perey MJ, Schmitt B, Leib SL Journal: Curr Drug Metab CYP2D6 phenotype prediction from genotype: which system is the best? Authors: Kirchheiner J Journal: Clin Pharmacol Ther It's nothing to laugh about: understanding disorders of emotional expression. Authors: Martin CM Journal: Consult Pharm Neuropsychotoxicity of abused drugs: potential of dextromethorphan and novel neuroprotective analogs of dextromethorphan with improved safety profiles in terms of abuse and neuroprotective effects. Authors: Shin EJ, Lee PH, Kim HJ, Nabeshima T, Kim HC Journal: J Pharmacol Sci CYP2D6 phenotyping with dextromethorphan. Authors: Wojtczak A, Rychlik-Sych M, Krochmalska-Ulacha E, Skretkowicz J Journal: Pharmacol Rep Effect of an Antiretroviral Regimen Containing Ritonavir Boosted Lopinavir on Intestinal and Hepatic CYP3A, CYP2D6 and P-glycoprotein in HIV-infected Patients. Authors: Wyen C, Fuhr U, Frank D, Aarnoutse R, Klaassen T, Lazar A, Seeringer A, Doroshyenko O, Kirchheiner J, Abdulrazik F, Schmeisser N, Lehmann C, Hein W, Schömig E, Burger D, Fätkenheuer G, Jetter A Journal: Clin Pharmacol Ther High-frequency rhythmic cortical myoclonus in a long-surviving patient with nonketotic hypergylcemia. Authors: Mastrangelo M, Canafoglia L, Franceschetti S, Oppezzo C, Mosca F, Menni F, Parini R, Ciano C, Scaioli V, Panzica F Journal: J Child Neurol Effect of sampling procedures of release testing on drug release and scale-up production feasibility of multiple-unit dextromethorphan resinate tablets: a technical note. Authors: Pongjanyakul T Journal: AAPS PharmSciTech Neonatal nonketotic hyperglycinemia. Authors: Bhamkar RP, Colaco P Journal: Indian J Pediatr Development of sustained release fast-disintegrating tablets using various polymer-coated ion-exchange resin complexes. Authors: Jeong SH, Park K Journal: Int J Pharm [Effect of Qingkailing injection on rat CYP1A2 and CYP2D6 activity] Authors: Liu Y, Wang J, Bao YY, Yu WJ, Zhu DL Journal: Zhongguo Zhong Yao Za Zhi An evaluation of the genotoxicity of the antitussive drug Dextromethorphan. Authors: Aardema MJ, Robison SH, Gatehouse D, Johnston G Journal: Regul Toxicol Pharmacol Premedication with low-dose dextromethorphan does not reduce pain following oral surgery. Authors: Gordon SM Journal: J Evid Based Dent Pract Development and validation of a chemical hydrolysis method for dextromethorphan and dextrophan determination in urine samples: application to the assessment of CYP2D6 activity in fibromyalgia patients. Authors: Daali Y, Cherkaoui S, Doffey-Lazeyras F, Dayer P, Desmeules JA Journal: J Chromatogr B Analyt Technol Biomed Life Sci Blockade of NMDA receptors prevents analgesic tolerance to repeated transcutaneous electrical nerve stimulation (TENS) in rats. Authors: Hingne PM, Sluka KA Journal: J Pain Effect of honey, dextromethorphan, and no treatment on nocturnal cough and sleep quality for coughing children and their parents. Authors: Paul IM, Beiler J, McMonagle A, Shaffer ML, Duda L, Berlin CM Journal: Arch Pediatr Adolesc Med CYP2D6-Mediated metabolism of a novel acyl coenzyme A:cholesterol acyltransferase inhibitor, pactimibe, and its unique plasma metabolite, R-125528. Authors: Kotsuma M, Tokui T, Ishizuka-Ozeki T, Honda T, Iwabuchi H, Murai T, Ikeda T, Saji H Journal: Drug Metab Dispos Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice. Authors: Felmlee MA, Lon HK, Gonzalez FJ, Yu AM Journal: Drug Metab Dispos Development of CYP2D6 and CYP3A4 in the first year of life. Authors: Johnson TN, Tucker GT, Rostami-Hodjegan A Journal: Clin Pharmacol Ther Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions. Authors: Maréchal JD, Kemp CA, Roberts GC, Paine MJ, Wolf CR, Sutcliffe MJ Journal: Br J Pharmacol Serotonin syndrome in dextromethorphan ingestion responsive to propofol therapy. Authors: Ganetsky M, Babu KM, Boyer EW Journal: Pediatr Emerg Care The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype. Authors: Gaedigk A, Simon SD, Pearce RE, Bradford LD, Kennedy MJ, Leeder JS Journal: Clin Pharmacol Ther [Dangerous party drugs: A2 and cough medicines. Increasing interest among Swedish adolescents] Authors: Knudsen K, Hultén P, Sass M, Sallin K Journal: Lakartidningen The inhibitory effect of tannic acid on cytochrome P450 enzymes and NADPH-CYP reductase in rat and human liver microsomes. Authors: Yao HT, Chang YW, Lan SJ, Yeh TK Journal: Food Chem Toxicol [Fibromyalgia syndrome: new developments in pharmacotherapy] Authors: Harten P Journal: Z Rheumatol Effect of methamphetamine on cytochrome P450 activity. Authors: Dostalek M, Jurica J, Pistovcakova J, Hanesova M, Tomandl J, Linhart I, Sulcova A Journal: Xenobiotica Simultaneous analysis of dextromethorphan and its three metabolites in human plasma using an improved HPLC method with fluorometric detection. Authors: Lin SY, Chen CH, Ho HO, Chen HH, Sheu MT Journal: J Chromatogr B Analyt Technol Biomed Life Sci The effect of dextromethorphan in preventing cholecalciferol-induced poison shyness and sickness-induced anorexia in the laboratory Norway rat. Authors: Gould EM, Holmes SJ Journal: Pest Manag Sci The in vitro inhibitory potential of trade herbal products on human CYP2D6-mediated metabolism and the influence of ethanol. Authors: Hellum BH, Nilsen OG Journal: Basic Clin Pharmacol Toxicol Currently available cough suppressants for chronic cough. Authors: Chung KF Journal: Lung Active-site structure, binding and redox activity of the heme-thiolate enzyme CYP2D6 immobilized on coated Ag electrodes: a surface-enhanced resonance Raman scattering study. Authors: Bonifacio A, Millo D, Keizers PH, Boegschoten R, Commandeur JN, Vermeulen NP, Gooijer C, van der Zwan G Journal: J Biol Inorg Chem Are false-positive phencyclidine immunoassay instant-view multi-test results caused by overdose concentrations of Ibuprofen, metamizol, and dextromethorphan? Authors: Marchei E, Pellegrini M, Pichini S, Martín I, García-Algar O, Vall O Journal: Ther Drug Monit Effects of dextromethorphan on dopamine dependent behaviours in rats. Authors: Gaikwad RV, Gaonkar RK, Jadhav SA, Thorat VM, Jadhav JH, Balsara JJ Journal: Indian J Exp Biol Dextromethorphan poisoning: an evidence-based consensus guideline for out-of-hospital management. Authors: Chyka PA, Erdman AR, Manoguerra AS, Christianson G, Booze LL, Nelson LS, Woolf AD, Cobaugh DJ, Caravati EM, Scharman EJ, Troutman WG, Journal: Clin Toxicol (Phila) Dextromethorphan as a potential neuroprotective agent with unique mechanisms of action. Authors: Werling LL, Lauterbach EC, Calef U Journal: Neurologist Use of isolated hepatocyte preparations for cytochrome P450 inhibition studies: comparison with microsomes for Ki determination. Authors: Brown HS, Chadwick A, Houston JB Journal: Drug Metab Dispos Dextromethorphan-induced near-fatal suicide attempt in a slow metabolizer at cytochrome P450 2D6. Authors: Matin N, Kurani A, Kennedy CA, Liu QY Journal: Am J Geriatr Pharmacother Treatment of pathologic laughing and crying. Authors: Wortzel HS, Anderson CA, Arciniegas DB Journal: Curr Treat Options Neurol [Simultaneous determination of the inhibitory potency of compounds on the activity of five cytochrome P-450 enzymes using a cocktail probe substrates method] Authors: Gao ZW, Shi XJ, Yu C, Li SJ, Zhong MK Journal: Yao Xue Xue Bao Effects of paracetamol combined with dextromethorphan in human experimental muscle and skin pain. Authors: Olesen AE, Staahl C, Ali Z, Drewes AM, Arendt-Nielsen L Journal: Basic Clin Pharmacol Toxicol A comparison of the binding profiles of dextromethorphan, memantine, fluoxetine and amitriptyline: treatment of involuntary emotional expression disorder. Authors: Werling LL, Keller A, Frank JG, Nuwayhid SJ Journal: Exp Neurol Bone biology and physiology: implications for novel osteoblastic osteosarcoma treatments? Authors: Spangler JG Journal: Med Hypotheses Efficacy of pre- and postoperative oral dextromethorphan for reduction of intra- and 24-hour postoperative morphine consumption for transabdominal hysterectomy. Authors: Chau-In W, Sukmuan B, Ngamsangsirisapt K, Jirarareungsak W Journal: Pain Med Effect of cinacalcet hydrochloride, a new calcimimetic agent, on the pharmacokinetics of dextromethorphan: in vitro and clinical studies. Authors: Nakashima D, Takama H, Ogasawara Y, Kawakami T, Nishitoba T, Hoshi S, Uchida E, Tanaka H Journal: J Clin Pharmacol Effect of sodium ozagrel on the activity of rat CYP2D6. Authors: Wu H, Yu W, Huang L, Wang J, Tang X, Yang W, Liu Y, Yu H, Zhu D Journal: Eur J Pharmacol The spinal anaesthetic effect of dextromethorphan, dextrorphan, and 3-methoxymorphinan. Authors: Chen YW, Chen YC, Lin CN, Chu CC, Lin MT, Wang JJ, Kao CH Journal: Eur J Pharmacol FDA halts sales of some anti-vomiting suppositories...and are cough medications effective in children? Authors: Journal: Child Health Alert Mucolytics, expectorants, and mucokinetic medications. Authors: Rubin BK Journal: Respir Care Inactivation of CYP2D6 by methylenedioxymethamphetamine in different recombinant expression systems. Authors: Van LM, Hargreaves JA, Lennard MS, Tucker GT, Rostami-Hodjegan A Journal: Eur J Pharm Sci Oral administration of dextromethorphan does not produce neuronal vacuolation in the rat brain. Authors: Carliss RD, Radovsky A, Chengelis CP, O'Neill TP, Shuey DL Journal: Neurotoxicology Biotechnological synthesis of drug metabolites using human cytochrome P450 2D6 heterologously expressed in fission yeast exemplified for the designer drug metabolite 4'-hydroxymethyl-alpha-pyrrolidinobutyrophenone. Authors: Peters FT, Dragan CA, Wilde DR, Meyer MR, Zapp J, Bureik M, Maurer HH Journal: Biochem Pharmacol Neuroprotective evaluation of standardized extract of Centella asciatica in monosodium glutamate treated rats. Authors: Ramanathan M, Sivakumar S, Anandvijayakumar PR, Saravanababu C, Pandian PR Journal: Indian J Exp Biol In vitro interaction cocktail assay for nine major cytochrome P450 enzymes with 13 probe reactions and a single LC/MSMS run: analytical validation and testing with monoclonal anti-CYP antibodies. Authors: Tolonen A, Petsalo A, Turpeinen M, Uusitalo J, Pelkonen O Journal: J Mass Spectrom Dextromethorphan in Wisconsin drivers. Authors: Cochems A, Harding P, Liddicoat L Journal: J Anal Toxicol In vitro assessment of cytochrome P450 inhibition: strategies for increasing LC/MS-based assay throughput using a one-point IC(50) method and multiplexing high-performance liquid chromatography. Authors: Lin T, Pan K, Mordenti J, Pan L Journal: J Pharm Sci Electron density analyses of opioids: a comparative study. Authors: Scheins S, Messerschmidt M, Morgenroth W, Paulmann C, Luger P Journal: J Phys Chem A Methamphetamine exposure antagonizes N-methyl-D-aspartate receptor-mediated neurotoxicity in organotypic hippocampal slice cultures. Authors: Smith KJ, Self RL, Butler TR, Mullins MM, Ghayoumi L, Holley RC, Littleton JM, Prendergast MA Journal: Brain Res Effect of gender and age on the pharmacokinetics of repinotan. Authors: Heinig R, Sundaresan P, Shah A, Boettcher M Journal: Clin Drug Investig OTC product: Theraflu Thin Strips. Authors: Franks AS Journal: J Am Pharm Assoc (2003) OTC product: Zicam Cold and Flu Medicated Spoons. Authors: Olenak JL Journal: J Am Pharm Assoc (2003) OTC product: PediaCare Long-Acting Cough Freezer Pops. Authors: Marciniak MW Journal: J Am Pharm Assoc (2003) "Pharming": the abuse of prescription and over-the-counter drugs in teens. Authors: Levine DA Journal: Curr Opin Pediatr "Crystal dex:" free-base dextromethorphan. Authors: Hendrickson RG, Cloutier RL Journal: J Emerg Med The metabolism of midazolam and comparison with other CYP enzyme substrates during intestinal absorption: in vitro studies with rat everted gut sacs. Authors: Arellano C, Philibert C, Vachoux C, Woodley J, Houin G Journal: J Pharm Pharm Sci Cough mixture abuse as a novel cause of folate deficiency: a prospective, community-based, controlled study. Authors: Au WY, Tsang SK, Cheung BK, Siu TS, Ma ES, Tam S Journal: Haematologica Efficacy of a single evening dose of syrup containing paracetamol, dextromethorphan hydrobromide, doxylamine succinate and ephedrine sulfate in subjects with multiple common cold symptoms. Authors: Mizoguchi H, Wilson A, Jerdack GR, Hull JD, Goodale M, Grender JM, Tyler BA Journal: Int J Clin Pharmacol Ther Saturable uptake of lipophilic amine drugs into isolated hepatocytes: mechanisms and consequences for quantitative clearance prediction. Authors: Hallifax D, Houston JB Journal: Drug Metab Dispos Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17. Authors: Shen H, He MM, Liu H, Wrighton SA, Wang L, Guo B, Li C Journal: Drug Metab Dispos Novel approach to performing metabolite identification in drug metabolism. Authors: Nassar AE, Lee DY Journal: J Chromatogr Sci Dextromethorphan: a review of N-methyl-d-aspartate receptor antagonist in the management of pain. Authors: Siu A, Drachtman R Journal: CNS Drug Rev Activity of human P450 2D6 in biphasic solvent systems. Authors: Zhao J, Tan E, Ferras J, Auclair K Journal: Biotechnol Bioeng Dextromethorphan or dextrorphan have a local anesthetic effect on infiltrative cutaneous analgesia in rats. Authors: Chen YW, Chu KS, Lin CN, Tzeng JI, Chu CC, Lin MT, Wang JJ Journal: Anesth Analg Simultaneous analysis of cytochrome P450 probes-dextromethorphan, flurbiprofen and midazolam and their major metabolites by HPLC-mass-spectrometry/fluorescence after single-step extraction from plasma. Authors: Kumar A, Mann HJ, Remmel RP Journal: J Chromatogr B Analyt Technol Biomed Life Sci Separation of cold medicine ingredients using a precise MEKC method at elevated pH. Authors: Hasemann P, ter Balk M, Preu L, Wätzig H Journal: Electrophoresis In vitro LC-MS cocktail assays to simultaneously determine human cytochrome P450 activities. Authors: Dixit V, Hariparsad N, Desai P, Unadkat JD Journal: Biopharm Drug Dispos Therapeutic use of dextromethorphan: key learnings from treatment of pseudobulbar affect. Authors: Miller A, Panitch H Journal: J Neurol Sci Timolol metabolism in human liver microsomes is mediated principally by CYP2D6. Authors: Volotinen M, Turpeinen M, Tolonen A, Uusitalo J, Mäenpää J, Pelkonen O Journal: Drug Metab Dispos Involuntary emotional expression disorder: treating the untreated. Authors: Brooks BR Journal: CNS Spectr Development and full validation of six inhibition assays for five major cytochrome P450 enzymes in human liver microsomes using an automated 96-well microplate incubation format and LC-MS/MS analysis. Authors: Yao M, Zhu M, Sinz MW, Zhang H, Humphreys WG, Rodrigues AD, Dai R Journal: J Pharm Biomed Anal The neuropsychiatry of multiple sclerosis: a review of recent developments. Authors: Ghaffar O, Feinstein A Journal: Curr Opin Psychiatry Microbial transformation of dextromethorphan by Cunninghamella blakesleeana AS 3.153. Authors: Lin L, Huang H, Zhang P, Qi X, Zhong D Journal: Chem Pharm Bull (Tokyo)

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