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An opioid analgesic related to morphine but with less potent analgesic properties and mild sedative effects. It also acts centrally to suppress cough.
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Additional comments :
(Ardinex, Codeine Phosphate, Isocodeine, N-Methylmorphine)
Articles
Premedication with pregabalin 75 or 150 mg with ibuprofen to control pain after day-case gynaecological laparoscopic surgery. Authors: Jokela R, Ahonen J, Tallgren M, Haanpää M, Korttila K Journal: Br J Anaesth
Short reflex expirations (expiration reflexes) induced by mechanical stimulation of the trachea in anesthetized cats. Authors: Poliacek I, Rose MJ, Corrie LW, Wang C, Jakus J, Barani H, Stransky A, Polacek H, Halasova E, Bolser DC Journal: Cough
Cation-selective exhaustive injection and sweeping micellar electrokinetic chromatography for analysis of morphine and its four metabolites in human urine. Authors: Lin YH, Chiang JF, Lee MR, Lee RJ, Ko WK, Wu SM Journal: Electrophoresis
Driving under the influence of opiates: concentration relationships between morphine, codeine, 6-acetyl morphine, and ethyl morphine in blood. Authors: Jones AW, Holmgren A, Kugelberg FC Journal: J Anal Toxicol
Cognitive effects of opioids. Authors: Strassels SA Journal: Curr Pain Headache Rep
Evolutionary and cellular webs in benzylisoquinoline alkaloid biosynthesis. Authors: Liscombe DK, Facchini PJ Journal: Curr Opin Biotechnol
Cost-effectiveness analysis of the analgesic therapy of postoperative pain. Authors: Secoli SR, Padilha KG, Litvoc J Journal: Rev Lat Am Enfermagem
Conformation, catalytic site, and enzymatic mechanism of the PR10 allergen related enzyme norcoclaurine synthase. Authors: Berkner H, Schweimer K, Matecko I, Rösch P Journal: Biochem J
Glucuronidation of paracetamol by human liver microsomes in vitro / enzyme kinetic parameters and interactions with short-chain aliphatic alcohols and opiates. Authors: Boldt P, Rothschild MA, Kaeferstein H Journal: Arzneimittelforschung
Applicability of ultra-performance liquid chromatography-tandem mass spectrometry for heroin profiling. Authors: Lurie IS, Toske SG Journal: J Chromatogr A
Genetic mutations that prevent pain: implications for future pain medication. Authors: Oertel B, Lötsch J Journal: Pharmacogenomics
Determination of caffeine and associated compounds in food, beverages, natural products, pharmaceuticals, and cosmetics by micellar electrokinetic capillary chromatography. Authors: Injac R, Srdjenovic B, Prijatelj M, Boskovic M, Karljikovic-Rajic K, Strukelj B Journal: J Chromatogr Sci
[Pictures from the Dolphin Pharmacy in Copenhagen] Authors: Kruse PR, Kruse E, Norn S, Permin H Journal: Dan Medicinhist Arbog
The effects of oral ondansetron disintegrating tablets for prevention of at-home emesis in pediatric patients after ear-nose-throat surgery. Authors: Davis PJ, Fertal KM, Boretsky KR, Fedel GM, Ingram MD, Woelfel SK, Hoffmann PC, Gurnaney H, Young MC Journal: Anesth Analg
Reliability of self-reported use of amphetamine, barbiturates, benzodiazepines, cannabinoids, cocaine, methadone, and opiates among acutely hospitalized elderly medical patients. Authors: Glintborg B, Olsen L, Poulsen H, Linnet K, Dalhoff K Journal: Clin Toxicol (Phila)
CYP2D6 ultrarapid metabolism and morphine/codeine ratios in blood: was it codeine or heroin? Authors: He YJ, Brockmöller J, Schmidt H, Roots I, Kirchheiner J Journal: J Anal Toxicol
A comparison of methadone, oxycodone, and hydrocodone related deaths in Northeast Ohio. Authors: Baker DD, Jenkins AJ Journal: J Anal Toxicol
Concentration measurements of multiple analytes in human sera by near-infrared laser Raman spectroscopy. Authors: Qu JY, Wilson BC, Suria D Journal: Appl Opt
Undiagnosed Graves' Disease contributing to sleep disordered breathing in a child undergoing adenotonsillectomy. Authors: Ajala AM, Goodwin JA, Goodwin SR, Josephson GD Journal: Paediatr Anaesth
A randomized controlled trial comparing acetaminophen plus ibuprofen versus acetaminophen plus codeine plus caffeine after outpatient general surgery. Authors: Mitchell A, van Zanten SV, Inglis K, Porter G Journal: J Am Coll Surg
Locally administered ketorolac and bupivacaine for control of postoperative pain in breast augmentation patients: part II. 10-day follow-up. Authors: Mahabir RC, Peterson BD, Williamson JS, Valnicek SM, Williamson DG, East WE Journal: Plast Reconstr Surg
Short stay pyeloplasty: variables affecting pain and length of stay. Authors: Chamie K, Tanaka ST, Hu B, Kurzrock EA Journal: J Urol
Blood-brain barrier transport helps to explain discrepancies in in vivo potency between oxycodone and morphine. Authors: Boström E, Hammarlund-Udenaes M, Simonsson US Journal: Anesthesiology
Unexceptional seizure potential of tramadol or its enantiomers or metabolites in mice. Authors: Raffa RB, Stone DJ Journal: J Pharmacol Exp Ther
Prescribing opioids in renal failure. Authors: Droney J, Levy J, Quigley C Journal: J Opioid Manag
Simultaneous quantitative determination of amphetamines, ketamine, opiates and metabolites in human hair by gas chromatography/mass spectrometry. Authors: Wu YH, Lin KL, Chen SC, Chang YZ Journal: Rapid Commun Mass Spectrom
Pain management after craniotomy. Authors: Nemergut EC, Durieux ME, Missaghi NB, Himmelseher S Journal: Best Pract Res Clin Anaesthesiol
Abuse deterrence focus of upcoming opioid formulations. Authors: Lavine G Journal: Am J Health Syst Pharm
In vitro and in vivo evaluation of O-alkyl derivatives of tramadol. Authors: Shao L, Hewitt M, Jerussi TP, Wu F, Malcolm S, Grover P, Fang K, Koch P, Senanayake C, Bhongle N, Ribe S, Bakale R, Currie M Journal: Bioorg Med Chem Lett
[Liposomal boron delivery system for neutron capture therapy] Authors: Nakamura H Journal: Yakugaku Zasshi
CYP2D6 genotyping and codeine. Authors: de Leon J Journal: Paediatr Anaesth
Re: Apnea in a child after oral codeine: a genetic variant - an ultra-rapid metabolizer [corrected] Authors: de Wildt SN, Koren G Journal: Paediatr Anaesth
Codeine induced respiratory depression in a child. Authors: Stamer UM, Stüber F Journal: Paediatr Anaesth
Pharmacological characterization of noroxymorphone as a new opioid for spinal analgesia. Authors: Lemberg KK, Siiskonen AO, Kontinen VK, Yli-Kauhaluoma JT, Kalso EA Journal: Anesth Analg
Analgesic efficacy of controlled-release oxycodone in patients with uterine or ovarian cancer. Authors: Suzuki T, Morishita M, Ito E, Matsuura M, Tanaka R, Saito T Journal: Am J Ther
Diagnosis of menstrual headache and an open-label study among those with previously undiagnosed menstrually related migraine to evaluate the efficacy of sumatriptan 100 mg. Authors: Schreiber CP, Cady RK Journal: Clin Ther
Adverse drug interactions involving common prescription and over-the-counter analgesic agents. Authors: Hersh EV, Pinto A, Moore PA Journal: Clin Ther
Treatment of diarrhea in patients with inflammatory bowel disease: concepts and cautions. Authors: Shah SB, Hanauer SB Journal: Rev Gastroenterol Disord
A practical approach to treating patients with chronic diarrhea. Authors: Sellin JH Journal: Rev Gastroenterol Disord
Quantitative 1H NMR metabolomics reveals extensive metabolic reprogramming of primary and secondary metabolism in elicitor-treated opium poppy cell cultures. Authors: Zulak KG, Weljie AM, Vogel HJ, Facchini PJ Journal: BMC Plant Biol
Nurofen Plus misuse: an emerging cause of perforated gastric ulcer. Authors: Dutch MJ Journal: Med J Aust
Ranitidine (150 mg daily) inhibits wheal, flare, and itching reactions in skin-prick tests. Authors: Kupczyk M, Kupry? I, Boche?ska-Marciniak M, Górski P, Kuna P Journal: Allergy Asthma Proc
Comparison of analgesic effects and patient tolerability of nabilone and dihydrocodeine for chronic neuropathic pain: randomised, crossover, double blind study. Authors: Frank B, Serpell MG, Hughes J, Matthews JN, Kapur D Journal: BMJ
Hydrocodone/acetaminophen and tramadol chlorhydrate combination tablets for the management of chronic cancer pain: a double-blind comparative trial. Authors: Rodriguez RF, Castillo JM, Castillo MP, Montoya O, Daza P, Rodríguez MF, Restrepo JM, León ME, Angel AM Journal: Clin J Pain
Etoricoxib for pain management during thyroid surgery--a prospective, placebo-controlled study. Authors: Smirnov G, Terävä M, Tuomilehto H, Hujala K, Seppänen M, Kokki H Journal: Otolaryngol Head Neck Surg
[General practice study reveals simplification of therapy for physician and patients. Patient satisfaction and better quality of life] Authors: Journal: MMW Fortschr Med
Unexpected reduction in migraine and psychogenic headaches following rTMS treatment for major depression: a report of two cases. Authors: O'Reardon JP, Fontecha JF, Cristancho MA, Newman S Journal: CNS Spectr
[New study demonstrates dual effect of an oxycodone/naloxone combination. Strong pain palliation and preserving intestinal function] Authors: Journal: MMW Fortschr Med
An evaluation of the genotoxicity of the antitussive drug Dextromethorphan. Authors: Aardema MJ, Robison SH, Gatehouse D, Johnston G Journal: Regul Toxicol Pharmacol
Beliefs and social norms about codeine and promethazine hydrochloride cough syrup (CPHCS) use and addiction among multi-ethnic college students. Authors: Peters R, Yacoubian GS, Rhodes W, Forsythe KJ, Bowers KS, Eulian VM, Mangum CA, O'Neal JD, Martin Q, Essien EJ Journal: J Psychoactive Drugs
An exploratory study of OxyContin use among individuals with substance use disorders. Authors: Levy MS Journal: J Psychoactive Drugs
Codeine not safe for some breastfed infants. Authors: Stokowski LA Journal: Adv Neonatal Care
Determination of illicit drugs and their metabolites in human urine by liquid chromatography tandem mass spectrometry including relative ion intensity criterion. Authors: Concheiro M, De Castro A, Quintela O, Cruz A, López-Rivadulla M Journal: J Anal Toxicol
An estimate of the proportion of drug-facilitation of sexual assault in four U.S. localities. Authors: Juhascik MP, Negrusz A, Faugno D, Ledray L, Greene P, Lindner A, Haner B, Gaensslen RE Journal: J Forensic Sci
[Conversion ratio between intravenous oxycodone/hydrocotarnine and sustained-release oral oxycodone in patients with cancer pain] Authors: Kokubun H, Nakamura K, Fukawa M, Matoba M, Hoka S, Yago K Journal: Gan To Kagaku Ryoho
Multiple opioids in pain management. Authors: Gallagher R Journal: Can Fam Physician
Opioid analgesics for cancer pain: symptom control for the living or comfort for the dying? A qualitative study to investigate the factors influencing the decision to accept morphine for pain caused by cancer. Authors: Reid CM, Gooberman-Hill R, Hanks GW Journal: Ann Oncol
Coupling desorption electrospray ionisation and neutral desorption/extractive electrospray ionisation with a travelling-wave based ion mobility mass spectrometer for the analysis of drugs. Authors: Williams JP, Scrivens JH Journal: Rapid Commun Mass Spectrom
Codeine accumulation and elimination in larvae, pupae, and imago of the blowfly Lucilia sericata and effects on its development. Authors: Kharbouche H, Augsburger M, Cherix D, Sporkert F, Giroud C, Wyss C, Champod C, Mangin P Journal: Int J Legal Med
Stability of codeine phosphate in an extemporaneously compounded syrup. Authors: Dentinger PJ, Swenson CF Journal: Am J Health Syst Pharm
Non-prescribed use of pain relievers among adolescents in the United States. Authors: Wu LT, Pilowsky DJ, Patkar AA Journal: Drug Alcohol Depend
[Analytical confirmation of lethal heroin overdose by the use of liquid chromatography methods] Authors: Dordevi? S, Kilibarda V Journal: Vojnosanit Pregl
Codeine challenge in chronic urticaria patients. Authors: Giavina-Bianchi P, Dente M, Giavina-Bianchi M, Mota AA, Kalil J Journal: Allergol Immunopathol (Madr)
Fatal intoxication with a selective serotonin reuptake inhibitor, lorazepam, and codeine. Authors: Filter ER, Gorczynski L, Fernandes JR Journal: Am J Forensic Med Pathol
Oxycodone: a review of its use in the management of pain. Authors: Riley J, Eisenberg E, Müller-Schwefe G, Drewes AM, Arendt-Nielsen L Journal: Curr Med Res Opin
Transdermal fentanyl improves pain control and functionality in patients with osteoarthritis: an open-label Canadian trial. Authors: Choquette D, McCarthy TG, Rodrigues JF, Kelly AJ, Camacho F, Horbay GL, Husein-Bhabha FA Journal: Clin Rheumatol
Managing pain in chronic pancreatitis:therapeutic value of opioid treatment. Authors: Eisenberg E, Ståhl C, Drewes AM, Arendt-Nielsen L Journal: J Pain Palliat Care Pharmacother
Correlates of nonmedical use of hydromorphone and hydrocodone:results from a national household survey. Authors: Smith MY, Haddox JD, Di Marino ME Journal: J Pain Palliat Care Pharmacother
FDA bans sale of unapproved cough suppressants containing hydrocodone. Authors: Mitka M Journal: JAMA
Opioids applied topically to painful cutaneous malignant ulcers in a palliative care setting. Authors: Zeppetella G, Porzio G, Aielli F Journal: J Opioid Manag
Differentiation of opium and poppy straw using capillary electrophoresis and pattern recognition techniques. Authors: Reid RG, Durham DG, Boyle SP, Low AS, Wangboonskul J Journal: Anal Chim Acta
New methodology for the N-demethylation of opiate alkaloids. Authors: Dong Z, Scammells PJ Journal: J Org Chem
Analysis of pain management drugs, specifically fentanyl, in hair: application to forensic specimens. Authors: Moore C, Marinetti L, Coulter C, Crompton K Journal: Forensic Sci Int
Administration of fentanyl before remifentanil-based anaesthesia has no influence on post-operative pain or analgesic consumption. Authors: Lenz H, Raeder J, Hoymork SC Journal: Acta Anaesthesiol Scand
Predominance of illicit drugs and poly-drug use among drug-impaired drivers in Sweden. Authors: Holmgren A, Holmgren P, Kugelberg FC, Jones AW, Ahlner J Journal: Traffic Inj Prev
Complete soft palate necrosis and velopharyngeal insufficiency resulting from intranasal inhalation of prescription narcotics and cocaine. Authors: Birchenough SA, Borowitz K, Lin KY Journal: J Craniofac Surg
Codeine and tramadol analgesic efficacy and respiratory effects are influenced by CYP2D6 genotype. Authors: Stamer UM, Stüber F Journal: Anaesthesia
Pharmacogenetics: using DNA to optimize drug therapy. Authors: Lanfear DE, McLeod HL Journal: Am Fam Physician
Vitreous fluid quantification of opiates, cocaine, and benzoylecgonine: comparison of calibration curves in both blood and vitreous matrices with corresponding concentrations in blood. Authors: Antonides HM, Kiely ER, Marinetti LJ Journal: J Anal Toxicol
Stable isotopes as valid components for identification of drugs in biological specimens. Authors: Paul BD, Holler JM, Lyons TP, Past MR Journal: J Anal Toxicol
Rapid quantification of urinary oxycodone and oxymorphone using fast gas chromatography-mass spectrometry. Authors: McKinley S, Snyder JJ, Welsh E, Kazarian CM, Jamerson MH, Klette KL Journal: J Anal Toxicol
Prevalence and disposition of drugs of abuse and opioid treatment drugs in oral fluid. Authors: Cone EJ, Clarke J, Tsanaclis L Journal: J Anal Toxicol
Complicated pain management in a CYP450 2D6 poor metabolizer. Authors: Foster A, Mobley E, Wang Z Journal: Pain Pract
Pholcodine exposure raises serum IgE in patients with previous anaphylaxis to neuromuscular blocking agents. Authors: Harboe T, Johansson SG, Florvaag E, Oman H Journal: Allergy
Trace determination of cannabinoids and opiates in wastewater and surface waters by ultra-performance liquid chromatography-tandem mass spectrometry. Authors: Boleda MR, Galceran MT, Ventura F Journal: J Chromatogr A
Pharmacokinetics and variation in the clearance of oxycodone and hydrocotarnine in patients with cancer pain. Authors: Kokubun H, Fukawa M, Matoba M, Hoka S, Yamada Y, Yago K Journal: Biol Pharm Bull
The effect of single-dose tramadol on oxycodone clearance. Authors: Curry SC, Watts DJ, Katz KD, Bikin D, Bukaveckas BL Journal: J Emerg Med
Prescription OxyContin abuse among patients entering addiction treatment. Authors: Carise D, Dugosh KL, McLellan AT, Camilleri A, Woody GE, Lynch KG Journal: Am J Psychiatry
OxyContin abuse: who are the users? Authors: Rawson RA, Maxwell J, Rutkowski B Journal: Am J Psychiatry
Sex differences in the pharmacokinetics, oxidative metabolism and oral bioavailability of oxycodone in the Sprague-Dawley rat. Authors: Chan S, Edwards SR, Wyse BD, Smith MT Journal: Clin Exp Pharmacol Physiol
The challenging patient: HCV and alcoholic liver disease. Authors: Lucey MR, Lake JR Journal: Liver Transpl
How different is oxycodone from morphine? Authors: Kalso E Journal: Pain
Separation and determination of five major opium alkaloids with mixed mode of hydrophilic/cation-exchange monolith by pressurized capillary electrochromatography. Authors: Lin X, Wang J, Li L, Wang X, Lü H, Xie Z Journal: J Sep Sci
Improvements on enzymatic hydrolysis of human hair for illicit drug determination by gas chromatography/mass spectrometry. Authors: Míguez-Framil M, Moreda-Piñeiro A, Bermejo-Barrera P, López P, Tabernero MJ, Bermejo AM Journal: Anal Chem
Should codeine still be used for post-craniotomy analgesia? Authors: Sharma V, Sebastian J Journal: Br J Hosp Med (Lond)
Coma blisters. Authors: Waring WS, Sandilands EA Journal: Clin Toxicol (Phila)
Over-the-counter (OTC) medications to reduce cough as an adjunct to antibiotics for acute pneumonia in children and adults. Authors: Chang CC, Cheng AC, Chang AB Journal: Cochrane Database Syst Rev
Case reports: zoster pain in haematological malignancies: effective pain relief with oxycodone in patients unresponsive to other analgesic measures. Authors: Niscola P, Perrotti AP, del Poeta G, Romani C, Palombi M, Piccioni D, Scaramucci L, Tolu B, Tendas A, Cupelli L, Abruzzese E, D'Elia GM, Brunetti GA, Maurillo L, Giovannini M, Cartoni C, de Fabritiis P Journal: Herpes
Herpes zoster in immunocompromised patients. Authors: Volpi A, Stanberry L Journal: Herpes
Effects of carvedilol treatment in dogs with chronic mitral valvular disease. Authors: Marcondes-Santos M, Tarasoutchi F, Mansur AP, Strunz CM Journal: J Vet Intern Med
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