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| ampyrone |
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A metabolite of aminopyrine with analgesic and anti-inflammatory properties. It is used as a reagent for biochemical reactions producing peroxides or phenols. Ampyrone stimulates liver microsomes and is also used to measure extracellular water.
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Additional comments :
(Aminoantipyrine)
See Also: Aminopyrine, Liver Microsomes
Articles
 Effect of 4-aminoantipyrine on gastric compliance and liquid emptying in rats.
Authors: Vinagre AM, Collares EF
Journal: Braz J Med Biol Res
Inhibition of cyclooxygenases by dipyrone.
Authors: Pierre SC, Schmidt R, Brenneis C, Michaelis M, Geisslinger G, Scholich K
Journal: Br J Pharmacol
New and simple plate test for screening relative transfructosylation activity of fungi.
Authors: Dominguez A, Santos IM, Teixeira JA, Lima N
Journal: Rev Iberoam Micol
[Cooxidation of phenol and 4-aminoantipyrin, catalyzed by polymers and copolymers of horseradish root peroxidase and Penicillium funiculosum 46.1 glucose oxidase]
Authors: Eremin AN, Semashko TV, Mikha?lova RV
Journal: Prikl Biokhim Mikrobiol
[Detection of phenol by means of 4-aminophenazone according to Emerson]
Authors: Link A, Radau G
Journal: Pharmazie
Mechanism of ascorbic acid interference in biochemical tests that use peroxide and peroxidase to generate chromophore.
Authors: Martinello F, Luiz da Silva E
Journal: Clin Chim Acta
Determination of cefadroxil by sequential injection with spectrophotometric detector.
Authors: Makchit J, Upalee S, Thongpoon C, Liawruangrath B, Liawruangrath S
Journal: Anal Sci
Validation of a new high-performance liquid chromatography assay for nizatidine.
Authors: Yusuf A, Al Dgither S, Hammami MM
Journal: Ther Drug Monit
Kinetic modelling of phenol co-oxidation using horseradish peroxidase.
Authors: Carvalho RH, Lemos F, Lemos MA, Vojinovi? V, Fonseca LP, Cabral JM
Journal: Bioprocess Biosyst Eng
UV-vis, IR and (1)H NMR spectroscopic studies of some Schiff bases derivatives of 4-aminoantipyrine.
Authors: Issa RM, Khedr AM, Rizk HF
Journal: Spectrochim Acta A Mol Biomol Spectrosc
Determination of phenols in waters using micro-pumped multicommutation and spectrophotometric detection: an automated alternative to the standard procedure.
Authors: Ródenas-Torralba E, Morales-Rubio A, de la Guardia M
Journal: Anal Bioanal Chem
Determination of isoxsuprine hydrochloride by sequential injection visible spectrophotometry.
Authors: Beyene NW, Van Staden JF, Stefan RI, Aboul-Enein HY
Journal: Farmaco
Biological evaluation of some selected cyclic imides: mitochondrial effects and in vitro cytotoxicity.
Authors: Prado SR, Cechinel-Filho V, Campos-Buzzi F, Corrêa R, Cadena SM, de Oliveira MB
Journal: Z Naturforsch [C]
IR, UV-Vis, magnetic and thermal characterization of chelates of some catecholamines and 4-aminoantipyrine with Fe(III) and Cu(II).
Authors: Mohamed GG, Zayed MA, El-Dien FA, El-Nahas RG
Journal: Spectrochim Acta A Mol Biomol Spectrosc
Development and application of an integrated system for monitoring ethanol content of fuels.
Authors: Alhadeff EM, Salgado AM, Pereira N, Valdman B
Journal: Appl Biochem Biotechnol
Extracellular peroxidase production by Coprinus species from urea-treated soil.
Authors: Ikehata K, Buchanan ID, Smith DW
Journal: Can J Microbiol
Evidence of the effect of dipyrone on the central nervous system as a determinant of delayed gastric emptying observed in rats after its administration.
Authors: Collares EF, Vinagre AM
Journal: Braz J Med Biol Res
Determination of peroxides in saliva--kinetics of peroxide release into saliva during home-bleaching with Whitestrips and Vivastyle.
Authors: Hannig C, Zech R, Henze E, Dorr-Tolui R, Attin T
Journal: Arch Oral Biol
High-throughput screen for aromatic hydroxylation.
Authors: Otey CR, Joern JM
Journal: Methods Mol Biol
Allergic cholestatic hepatitis and exanthema induced by metamizole: verification by lymphocyte transformation test.
Authors: Herdeg C, Hilt F, Büchtemann A, Bianchi L, Klein R
Journal: Liver
Catalytic spectrofluorimetric determination of superoxide anion radical and superoxide dismutase activity using N,N-dimethylaniline as the substrate for horseradish peroxidase (HRP).
Authors: Tang B, Wang Y, Chen ZZ
Journal: Spectrochim Acta A Mol Biomol Spectrosc
Spectrophotometric determination of phenylephrine hydrochloride in pharmaceuticals by flow injection analysis exploiting the reaction with potassium ferricyanide and 4-aminoantipyrine.
Authors: Rocha JR, Galhardo CX, Natividade MA, Masini JC
Journal: J AOAC Int
Determination of polyphenols in wines by reaction with 4-aminoantipyrine and photometric flow-injection analysis.
Authors: Schoonen JW, Sales MG
Journal: Anal Bioanal Chem
Kinetic flow-injection determination of hydrogen peroxide by use of iron(III)-catalyzed coloration and its application to the determination of biological substances.
Authors: Maeuchihara N, Nakano S, Kawashima T
Journal: Anal Sci
Acceleration of an enzymatic reaction in a microchip.
Authors: Tanaka Y, Slyadnev MN, Sato K, Tokeshi M, Kim HB, Kitamori T
Journal: Anal Sci
Impairment of the metabolism of dipyrone in asymptomatic carriers of the hepatitis-B virus does not occur in rapid acetylators.
Authors: Levy M, Safadi R, Zylber-Katz E, Granit L, Caraco Y
Journal: Eur J Clin Pharmacol
Spectrophotometric determination of ritodrine and isoxsuprine hydrochlorides using 4-aminoantipyrine.
Authors: Revanasiddappa HD, Manju BG
Journal: J AOAC Int
A liquid-stable reagent for lactic acid levels. Application to the Hitachi 911 and Beckman CX7.
Authors: Artiss JD, Karcher RE, Cavanagh KT, Collins SL, Peterson VJ, Varma S, Zak B
Journal: Am J Clin Pathol
Determination of choline in milk and infant formulas by enzymatic analysis: collaborative study.
Authors: Woollard DC, Indyk HE
Journal: J AOAC Int
Fluorometric method for the enzymatic determination of cholesterol.
Authors: Amundson DM, Zhou M
Journal: J Biochem Biophys Methods
Cerebrospinal fluid and plasma concentrations of dipyrone metabolites after a single oral dose of dipyrone.
Authors: Cohen O, Zylber-Katz E, Caraco Y, Granit L, Levy M
Journal: Eur J Clin Pharmacol
Mechanisms of dopamine and dobutamine interference in biochemical tests that use peroxide and peroxidase to generate chromophore.
Authors: Karon BS, Daly TM, Scott MG
Journal: Clin Chem
Inhibition of acyl-CoA oxidase by phenol and its implication in measurement of the enzyme activity via the peroxidase-coupled assay system.
Authors: Gopalan KV, Srivastava DK
Journal: Anal Biochem
High-performance liquid chromatographic analysis of dipyrone metabolites to study their formation in human liver microsomes.
Authors: Geisslinger G, Böcker R, Levy M
Journal: Pharm Res
Optimization studies of components in enzymatic cholesterol reagents containing cholesterol oxidase from Nocardia erythropolis, Streptomyces sp, or Pseudomonas fluorescens.
Authors: Lolekha PH, Teerajetkul Y
Journal: J Clin Lab Anal
Dipyrone metabolism in liver disease.
Authors: Zylber-Katz E, Caraco Y, Granit L, Levy M
Journal: Clin Pharmacol Ther
Determination of antipyrine metabolites in human plasma by solid-phase extraction and micellar liquid chromatography.
Authors: Carretero I, Vadillo JM, Laserna JJ
Journal: Analyst
Aminopyrine metabolism in man: the acetylation of aminoantipyrine cosegregates with acetylation of caffeine.
Authors: Agúndez JA, Carrillo JA, Martínez C, Benítez J
Journal: Ther Drug Monit
[Co-oxidation of phenols and 4-aminoantipyrene catalyzed by microperoxidase and their complexes with proteins]
Authors: Metelitsa DI, Arapova GS, Vidzhina?te RA, Demcheva MV, Litvinchuk AV, Razumas VI
Journal: Biokhimiia
Colorimetric determination of prenalterol hydrochloride in dosage forms.
Authors: Aly FA, Belal F, Walash MI
Journal: J Pharm Biomed Anal
[In vivo nitrosation of methimazole in humans]
Authors: Ziebarth D
Journal: Arch Pharm (Weinheim)
Enzymatic measurement of phosphatidylglycerol in amniotic fluid.
Authors: Jones GW, Ashwood ER
Journal: Clin Chem
Validity of saliva samples for the estimation of dipyrone metabolites pharmacokinetics.
Authors: Caraco Y, Zylber-Katz E, Granit L, Levy M
Journal: Arzneimittelforschung
Interaction of myeloperoxidase and elastase enzyme activity with the antihypertensive agents hydralazine and dihydralazine.
Authors: Hansson AL, Nässberger L
Journal: Pharmacol Toxicol
In vivo release of water-soluble drugs from stabilized water-in-oil-in-water (W/O/W) type multiple emulsions following intravenous administrations using rats.
Authors: Miyakawa T, Zhang W, Uchida T, Kim NS, Goto S
Journal: Biol Pharm Bull
Report of the Association of British Pharmaceutical Industries Collaborative Study Group. Collaborative study to evaluate the inter/intra laboratory reproducibility and phenotypic stability of Salmonella typhimurium TA97a and TA102.
Authors: Wilcox P, Wedd DJ, Gatehouse D
Journal: Mutagenesis
Renal selective N-acetyl-L-gamma-glutamyl prodrugs: studies on the selectivity of some model prodrugs.
Authors: Drieman JC, Thijssen HH, Struyker-Boudier HA
Journal: Br J Pharmacol
[Aminopyrazolone free radicals in the hydrogen peroxide oxidation reaction]
Authors: Iogannsen MG, Petrov AS, Kachurin AM
Journal: Vopr Med Khim
The kinetics of metamizol and its metabolites in critical-care patients with acute renal dysfunction.
Authors: Heinemeyer G, Gramm HJ, Roots I, Dennhardt R, Simgen W
Journal: Eur J Clin Pharmacol
[The effect of monoclonal and polyclonal antibodies to peroxidase on combined peroxidase oxidation of 4-iodophenol with luminol and 4-aminoantipyrine]
Authors: Litvinchuk AV, Metelitsa DI, Savenkova MI, Cherednikova TV, Kim BB, Pisarev VV
Journal: Biokhimiia
Oxidation of hydroquinone by both cellular and extracellular grapevine peroxidase fractions.
Authors: Zapata JM, Caldéron AA, Muñoz R, Ros Barceló A
Journal: Biochimie
Formation and excretion of dipyrone metabolites in man.
Authors: Zylber-Katz E, Granit L, Levy M
Journal: Eur J Clin Pharmacol
[Preparation of stable W/O/W type multiple emulsion containing water-soluble drugs and in vitro evaluation of its drug-releasing properties]
Authors: Zhang W, Miyakawa T, Uchida T, Goto S
Journal: Yakugaku Zasshi
[Releasing properties of water soluble drug in internal water phase of W/O/W multiple emulsions]
Authors: Goto S, Nakata K, Miyakawa T, Zhang W, Uchida T
Journal: Yakugaku Zasshi
Cytochrome c-catalyzed oxidation of organic molecules by hydrogen peroxide.
Authors: Radi R, Thomson L, Rubbo H, Prodanov E
Journal: Arch Biochem Biophys
Assay for detection and enumeration of genetically engineered microorganisms which is based on the activity of a deregulated 2,4-dichlorophenoxyacetate monooxygenase.
Authors: King RJ, Short KA, Seidler RJ
Journal: Appl Environ Microbiol
[Homogeneous immunoenzyme analysis of human immunoglobulin G using horseradish peroxidase]
Authors: Savenkova MN
Journal: Prikl Biokhim Mikrobiol
Neurotoxic esterase (NTE) assay: optimized conditions based on detergent-induced shifts in the phenol/4-aminoantipyrine chromophore spectrum.
Authors: Kayyali US, Moore TB, Randall JC, Richardson RJ
Journal: J Anal Toxicol
[Comparative studies on delayed type hypersensitivity of low-molecular compounds and compound-protein conjugates in rabbits]
Authors: Kimura T, Ishikawa N, Shinkai K
Journal: Arerugi
Zymographic screening of plant peroxidase isoenzymes oxidizing 4-hydroxystilbenes.
Authors: Calderón AA, Pedreño MA, Ros-Barceló A, Muñoz R
Journal: Electrophoresis
Pharmacokinetics of metamizol metabolites in healthy subjects after a single oral dose of metamizol sodium.
Authors: Vlahov V, Badian M, Verho M, Bacracheva N
Journal: Eur J Clin Pharmacol
Antioxidant characteristics of some potential anticataract agents. Studies of aspirin, paracetamol, and bendazac provide support for an oxidative component of cataract.
Authors: Woollard AC, Wolff SP, Bascal ZA
Journal: Free Radic Biol Med
Effect of inhibiting prostaglandin synthesis in pregnant sheep with 4-aminoantipyrine under normothermic and hyperthermic conditions.
Authors: Andrianakis P, Walker DW, Ralph MM, Thorburn GD
Journal: Am J Obstet Gynecol
Application of amperometric detection to the high-performance liquid chromatographic determination of antipyrine and 4-aminoantipyrine in urine.
Authors: Burcinová A, Tichý M, Pacáková V, Stulík K
Journal: J Chromatogr
Spectrophotometric determination of 4-aminoantipyrine in aqueous solution by coupling with diazotised 4-nitroaniline.
Authors: Al-Abachi MQ, Al-Delami AM, Al-Najafi S
Journal: Analyst
Mutagenicity of 4-aminoantipyrine and 4-nitrosoantipyrine, the C-nitroso derivative of antipyrine.
Authors: Parisis DM, Rao GS
Journal: Mutat Res
[Demonstration by lymphocyte transformation test of the allergic genesis in a case of acute hepatitis]
Authors: Federmann G, Becker EW, Tautorat H, Penschuck C, Berg PA
Journal: Dtsch Med Wochenschr
Enzymic determination of the free cholesterol fraction of high-density lipoprotein in plasma with use of 2,4,6-tribromo-3-hydroxybenzoic acid.
Authors: Moshides JS
Journal: Clin Chem
Aminopyrine metabolism by multiple forms of cytochrome P-450 from rat liver microsomes: simultaneous quantitation of four aminopyrine metabolites by high-performance liquid chromatography.
Authors: Imaoka S, Inoue K, Funae Y
Journal: Arch Biochem Biophys
An enzymatic method for erythrocyte acetylcholinesterase.
Authors: Abernethy MH, Fitzgerald HP, Ahern KM
Journal: Clin Chem
Dose-dependent pharmacokinetics of metabolites of dipyrone in saliva.
Authors: Neddermann E, Rohdewald P
Journal: Eur J Drug Metab Pharmacokinet
Investigation of an alkylamine modified and pH-controlled mobile phase for separation of pyrazolone derivatives by high-performance liquid chromatography.
Authors: Dimitrova B, Budevsky O
Journal: J Chromatogr
Simple high-performance liquid chromatographic method for simultaneous determination of aminopyrine and its metabolites.
Authors: D'Souza MJ, Zemaitis MA, Burckart GJ, Venkataramanan R
Journal: J Chromatogr
Further metabolism of 4-acetylaminoantipyrine, the major metabolite of aminopyrine, in rats.
Authors: Tanaka T, Kaneo Y, Goromaru T, Iguchi S
Journal: Chem Pharm Bull (Tokyo)
Effect of antipyrine on prostaglandin levels and uterine and umbilical blood flow.
Authors: Cashner KA, Skillman CA, Brockman D, Mack C, Clark KE
Journal: Am J Obstet Gynecol
Reversal of the effects of 4-amino-antipyrine on myometrial and cervical electromyographic activity by PGF2 alpha in the ovariectomized estradiol-replaced non-pregnant ewe.
Authors: Yarrington G, Fontwit K, Figueroa JP, Massmann A, Nathanielsz PW
Journal: Yale J Biol Med
[Characteristics of induced aminopyrine N-demethylase]
Authors: Gerasimov KE, Mitrofanov DV, Tsyrlov IB
Journal: Farmakol Toksikol
[An enzymatic color test for determining uric acid by the uricase-phenol-aminoantipyrine method]
Authors: Krüger W, Quitzsch G, Richter V, Rotzsch W
Journal: Z Med Lab Diagn
Comments on the uricase/peroxidase--phenol--4--aminoantipyrine reaction.
Authors: Pachla LA, Reynolds DL, Wright DS
Journal: Clin Chem
[Enzymatic micromethod of determining glucose in serum, plasma and whole blood]
Authors: Lukicheva TI, Prudnik IM, Doroguntseva IN
Journal: Lab Delo
[The influence of chronic renal insufficiency on the demethylating activities of various cytochrome P-450 subspecies in humans]
Authors: Simon HU, Günther K, Balogh A, Ortweiler W, Splinter FK, Stein G, Traeger A
Journal: Pharmazie
Inhibition of arachidonic acid metabolism by antipyrine and 4-aminoantipyrine.
Authors: Cohen D, Corbin J, Figueroa JP, Nathanielsz PW, Mitchell MD
Journal: Am J Obstet Gynecol
Determination of serum triglycerides by an accurate enzymatic method not affected by free glycerol.
Authors: Sullivan DR, Kruijswijk Z, West CE, Kohlmeier M, Katan MB
Journal: Clin Chem
Pharmacokinetic evidence for blood flow depression in dose dependent disposition of 4-aminoantipyrine in rabbits.
Authors: Mitsuyama S, Masumi A, Katayama K, Kakemi M, Koizumi T
Journal: J Pharmacobiodyn
Plasma protein binding of dipyrone metabolites in man.
Authors: Zylber-Katz E, Granit L, Levy M
Journal: Eur J Clin Pharmacol
Effect of dipyrone, acetylsalicylic acid and acetaminophen on human neutrophil chemotaxis.
Authors: Matzner Y, Drexler R, Levy M
Journal: Eur J Clin Invest
Effect of fetal intravascular 4-aminoantipyrine infusions on myometrial activity (contractures) at 125 to 143 days' gestation in the pregnant sheep.
Authors: El Badry A, Figueroa JP, Poore ER, Sunderji S, Levine S, Mitchell MD, Nathanielsz PW
Journal: Am J Obstet Gynecol
The effect of myometrial contractures on uterine blood flow in the pregnant sheep at 114 to 140 days' gestation measured by the 4-aminoantipyrine equilibrium diffusion technique.
Authors: Sunderji SG, El Badry A, Poore ER, Figueroa JP, Nathanielsz PW
Journal: Am J Obstet Gynecol
Influence of blood proteins on biomedical analysis. VI. Effect of bovine serum albumin on the color reaction of xanthurenic acid with 4-aminoantipyrine--inhibition of antipyrine red production by bovine serum albumin.
Authors: Sakoguchi T, Kobayashi K, Kimura M, Hase A, Shimozawa M, Matsuoka A
Journal: Chem Pharm Bull (Tokyo)
Plasma kinetics of dipyrone metabolites in rapid and slow acetylators.
Authors: Levy M, Flusser D, Zylber-Katz E, Granit L
Journal: Eur J Clin Pharmacol
[Synthesis of aminoacyl derivatives of 4-aminoantipyrine. IV. Amino acid derivatives with D configuration]
Authors: Kwapiszewski W, Kolwas J
Journal: Acta Pol Pharm
[Metamizol--acute overdose with suicidal intent]
Authors: Wolhoff H, Altrogge G, Pola W, Sistovaris N
Journal: Dtsch Med Wochenschr
Formation of diiodotyrosine from thyroxine. Ether-link cleavage, an alternate pathway of thyroxine metabolism.
Authors: Balsam A, Sexton F, Borges M, Ingbar SH
Journal: J Clin Invest
Thin-layer chromatographic determination of major metamizole metabolites in serum and urine.
Authors: Sistovaris N, Pola W, Wolhoff H
Journal: J Chromatogr
Simultaneous determination of aminopyrine hydroxylation and aminopyrine N-demethylation in liver microsomes by high-performance liquid chromatography.
Authors: Inoue K, Fujimori K, Mizokami K, Sunouchi M, Takanaka A, Omori Y
Journal: J Chromatogr
The unusual occurrence of 4-aminoantipyrine (4-aminophenazone) in human biological fluids.
Authors: Bailey DN
Journal: J Anal Toxicol
Induction of hepatic gamma-glutamyl transpeptidase in rats by repeated administration of aminopyrine.
Authors: Satoh T, Igarasgi T, Ueno K, Kitagawa H
Journal: Dev Toxicol Environ Sci
Induction of hepatic gamma-glutamyl transpeptidase in rats by repeated administration of aminopyrine.
Authors: Satoh T, Igarashi T, Hirota T, Kitagawa H
Journal: J Pharmacol Exp Ther
Preparation and properties of primary maintenance cultures of adult rabbit hepatocytes.
Authors: Poole A, Chasseaud LF, Bridges JW
Journal: Toxicology
Mutagenicity of N-nitroso compounds formed by the reaction of sulpyrine with nitrite; effects of cysteine and its derivatives.
Authors: Sakai A, Tanimura A
Journal: IARC Sci Publ
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