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aminorex An amphetamine-like anorectic agent. It may cause pulmonary hypertension.


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Additional comments :
(Aminoxafen)


See Also: Muscimol, Pemoline



Articles



PubmedPharmacokinetics and effects of aminorex in horses.
Authors:  Soma LR, Rudy JA, Uboh CE, Xu F, Snapp HM
Journal: Am J Vet Res

PubmedTemporal trends and drug exposures in pulmonary hypertension: an American experience.
Authors:  Walker AM, Langleben D, Korelitz JJ, Rich S, Rubin LJ, Strom BL, Gonin R, Keast S, Badesch D, Barst RJ, Bourge RC, Channick R, Frost A, Gaine S, McGoon M, McLaughlin V, Murali S, Oudiz RJ, Robbins IM, Tapson V, Abenhaim L, Constantine G
Journal: Am Heart J

PubmedSafety of drug therapies used for weight loss and treatment of obesity.
Authors:  Ioannides-Demos LL, Proietto J, Tonkin AM, McNeil JJ
Journal: Drug Saf

PubmedA century of pulmonary hemodynamics.
Authors:  Fishman AP
Journal: Am J Respir Crit Care Med

PubmedPrimary pulmonary arterial hypertension: a look back.
Authors:  Fishman AP
Journal: J Am Coll Cardiol

PubmedNoradrenergic modulation of ephedrine-induced hypophagia.
Authors:  Wellman PJ, Miller DK, Ho DH
Journal: Synapse

PubmedAnorexigen-related cardiopulmonary toxicity.
Authors:  Gross SB, Lepor NE
Journal: Rev Cardiovasc Med

PubmedTherapeutic and adverse actions of serotonin transporter substrates.
Authors:  Rothman RB, Baumann MH
Journal: Pharmacol Ther

PubmedAppetite suppressants as agonist substitution therapies for stimulant dependence.
Authors:  Rothman RB, Blough BE, Baumann MH
Journal: Ann N Y Acad Sci

Pubmed[Pulmonary hypertension and obesity]
Authors:  Sztrymf B, Ioos V, Sitbon O, Parent F, Simonneau G, Humbert M
Journal: Rev Pneumol Clin

PubmedEffects on serotonin in rat hypothalamus of D-fenfluramine, aminorex, phentermine and fluoxetine.
Authors:  Tao R, Fray A, Aspley S, Brammer R, Heal D, Auerbach S
Journal: Eur J Pharmacol

PubmedAnorexigen-induced pulmonary hypertension and the serotonin (5-HT) hypothesis: lessons for the future in pathogenesis.
Authors:  Eddahibi S, Adnot S
Journal: Respir Res

PubmedRisk factors for pulmonary arterial hypertension.
Authors:  Humbert M, Nunes H, Sitbon O, Parent F, Hervé P, Simonneau G
Journal: Clin Chest Med

PubmedEffects of anorexinogen agents on cloned voltage-gated K(+) channel hKv1.5.
Authors:  Perchenet L, Hilfiger L, Mizrahi J, Clément-Chomienne O
Journal: J Pharmacol Exp Ther

Pubmed[Drug induced pulmonary hypertension]
Authors:  Sato N, Nakanishi N
Journal: Nippon Rinsho

PubmedAnorectic drugs and pulmonary hypertension from the bedside to the bench.
Authors:  Michelakis ED, Weir EK
Journal: Am J Med Sci

PubmedRecreational use of aminorex and pulmonary hypertension.
Authors:  Gaine SP, Rubin LJ, Kmetzo JJ, Palevsky HI, Traill TA
Journal: Chest

PubmedAmphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin.
Authors:  Rothman RB, Baumann MH, Dersch CM, Romero DV, Rice KC, Carroll FI, Partilla JS
Journal: Synapse

Pubmed[Obesity: principles of drug therapy]
Authors:  Imoberdorf R, Ballmer PE
Journal: Ther Umsch

Pubmed[Development of pulmonary hypertension and multi-valvular damage caused by appetite depressants]
Authors:  Goldstein SE, Levy Y, Shoenfeld Y
Journal: Harefuah

Pubmed[Anorectics and pulmonary hypertension]
Authors:  Bíbová J, Hampl V
Journal: Cas Lek Cesk

PubmedAppetite suppressants and cardiac valvulopathy. Current clinical perspectives.
Authors:  Gross SB
Journal: Adv Nurse Pract

PubmedDelayed onset of pulmonary hypertension associated with an appetite suppressant, mazindol: a case report.
Authors:  Hagiwara M, Tsuchida A, Hyakkoku M, Nishizato K, Asai T, Nozawa Y, Tsuchihashi K, Shimamoto K
Journal: Jpn Circ J

PubmedAminorex to Fen/Phen: an epidemic foretold.
Authors:  Pollick C
Journal: Circulation

PubmedAminorex to Fen/Phen: an epidemic foretold.
Authors:  Tellier P
Journal: Circulation

PubmedAminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension.
Authors:  Rothman RB, Ayestas MA, Dersch CM, Baumann MH
Journal: Circulation

PubmedComplex vascular lesions at autopsy in a patient with phentermine-fenfluramine use and rapidly progressing pulmonary hypertension.
Authors:  Strother J, Fedullo P, Yi ES, Masliah E
Journal: Arch Pathol Lab Med

PubmedAminorex to fen/phen: an epidemic foretold.
Authors:  Fishman AP
Journal: Circulation

PubmedDiscriminative stimulus effects of S(-)-methcathinone (CAT): a potent stimulant drug of abuse.
Authors:  Young R, Glennon RA
Journal: Psychopharmacology (Berl)

PubmedMonoclonal endothelial cells in appetite suppressant-associated pulmonary hypertension.
Authors:  Tuder RM, Radisavljevic Z, Shroyer KR, Polak JM, Voelkel NF
Journal: Am J Respir Crit Care Med

PubmedRelearning the lessons of history: anorexigens and pulmonary hypertension.
Authors:  Langleben D
Journal: Chest

PubmedTwo different drug-induced pulmonary complications in a patient suffering from rheumatoid arthritis.
Authors:  Leeb BF, Scheinecker C, Schweitzer H, Smolen JS
Journal: Br J Rheumatol

PubmedAminorex, dexfenfluramine, and primary pulmonary hypertension.
Authors:  Kramer MS, Lane DA
Journal: J Clin Epidemiol

PubmedThe effect of anticoagulant therapy in primary and anorectic drug-induced pulmonary hypertension.
Authors:  Frank H, Mlczoch J, Huber K, Schuster E, Gurtner HP, Kneussl M
Journal: Chest

PubmedHerbs, seeds, oil and eggs: a vasotoxic salad.
Authors:  Weber KT
Journal: Cardiovasc Res

PubmedAppetite-suppressant drugs and primary pulmonary hypertension.
Authors:  Fishman AP
Journal: N Engl J Med

PubmedThe effects of aminorex and related compounds on brain monoamines and metabolites in CBA mice.
Authors:  Zheng Y, Russell B, Schmierer D, Laverty R
Journal: J Pharm Pharmacol

PubmedEffects of chronic dexfenfluramine treatment on pulmonary hemodynamics in dogs.
Authors:  Naeije R, Maggiorini M, Delcroix M, Leeman M, Mélot C
Journal: Am J Respir Crit Care Med

PubmedAnorexic agents aminorex, fenfluramine, and dexfenfluramine inhibit potassium current in rat pulmonary vascular smooth muscle and cause pulmonary vasoconstriction.
Authors:  Weir EK, Reeve HL, Huang JM, Michelakis E, Nelson DP, Hampl V, Archer SL
Journal: Circulation

Pubmed[Iatrogenic pulmonary artery hypertension]
Authors:  Weitzenblum E, Kessler R, Chaouat A
Journal: Rev Mal Respir

PubmedMetabolism of 4-methylaminorex ("EU4EA") in the rat.
Authors:  Henderson GL, Harkey MR, Chueh YT
Journal: J Anal Toxicol

PubmedStimulus properties of some analogues of 4-methylaminorex.
Authors:  Russell BR, Beresford RA, Schmierer DM, McNaughton N, Clark CR
Journal: Pharmacol Biochem Behav

PubmedPulmonary hypertension and dexfenfluramine.
Authors:  Cacoub P, Dorent R, Nataf P, Houppe JP, Piette JC, Godeau P, Gandjbakhch I
Journal: Eur J Clin Pharmacol

PubmedEvaluation of the abuse liability of aminorex.
Authors:  Woolverton WL, Massey BW, Winger G, Patrick GA, Harris LS
Journal: Drug Alcohol Depend

Pubmed[Dietary pulmonary hypertension]
Authors:  Takagi K, Kondoh M
Journal: Ryoikibetsu Shokogun Shirizu

Pubmed[Primary pulmonary hypertension]
Authors:  Winkler J
Journal: Z Gesamte Inn Med

Pubmed[Aminorex-induced, plexogenic pulmonary arteriopathy: 25 years later!]
Authors:  Frank H, Gurtner HP, Kneussl M, Lang I, Mlczoch J
Journal: Z Kardiol

PubmedCocaine-stimulus generalization to two new designer drugs: methcathinone and 4-methylaminorex.
Authors:  Young R, Glennon RA
Journal: Pharmacol Biochem Behav

PubmedAminorex produces stimulus effects similar to amphetamine and unlike those of fenfluramine.
Authors:  Young R
Journal: Pharmacol Biochem Behav

Pubmed[Long-term follow-up of pulmonary hypertension of unknown etiology]
Authors:  Lang I, Kneussl M, Frank H, Mlczoch J
Journal: Pneumologie

PubmedA fatality involving U4Euh, a cyclic derivative of phenylpropanolamine.
Authors:  Davis FT, Brewster ME
Journal: J Forensic Sci

PubmedSpecificity of pulmonary vascular lesions in primary pulmonary hypertension. A reappraisal.
Authors:  Pietra GG, Rüttner JR
Journal: Respiration

Pubmed[Prolonged survey of cases of pulmonary hypertension in relation to consumption of aminorex. Histological, quantitative and morphometric study of 9 cases]
Authors:  Widgren S
Journal: Schweiz Med Wochenschr

PubmedDevelopment of pulmonary aneurysm in primary pulmonary hypertension: a case report.
Authors:  Nienaber CA, Spielmann RP, Montz R, Bleifeld W, Mathey DG
Journal: Angiology

PubmedPolymorphic debrisoquine and mephenytoin hydroxylation in patients with pulmonary hypertension of vascular origin after aminorex fumarate.
Authors:  Saner H, Gurtner HP, Preisig R, Küpfer A
Journal: Eur J Clin Pharmacol

PubmedPrimary pulmonary hypertension. An analysis of 28 cases and a review of the literature.
Authors:  Hughes JD, Rubin LJ
Journal: Medicine (Baltimore)

Pubmed[Chronic pulmonary hypertension of vascular etiology, plexogenic pulmonary arteriopathy and the appetite depressant Aminorex: lessons from an epidemic]
Authors:  Gurtner HP
Journal: Schweiz Med Wochenschr

Pubmed[Chronic pulmonary hypertension of vascular origin, plexogenic pulmonary arteriopathy and the appetite depressant aminorex: addenda to an epidemic]
Authors:  Gurtner HP
Journal: Schweiz Med Wochenschr

PubmedPulmonary hypertension associated with portal thrombosis.
Authors:  Flemale A, Sabot JP, Popijn M, Procureur M, Urbain G, Dierckx JP, Delmez JP
Journal: Eur J Respir Dis

PubmedLong-term follow-up of pulmonary hypertension in patients with and without anorectic drug intake.
Authors:  Loogen F, Worth H, Schwan G, Goeckenjan G, Lösse B, Horstkotte D
Journal: Cor Vasa

PubmedAminorex and pulmonary hypertension. A review.
Authors:  Gurtner HP
Journal: Cor Vasa

PubmedThrombogenic effects of xenobiotics.
Authors:  Zbinden G, Grimm L
Journal: Arch Toxicol Suppl

Pubmed[Current status of plexogenic pulmonary arteriopathy of unknown origin]
Authors:  Lockhart A
Journal: Bull Eur Physiopathol Respir

Pubmed[Long-term course of primary vascular pulmonary hypertension with and without intake of appetite depressants]
Authors:  Voss H, Feigel H, Bücking J
Journal: Z Kardiol

Pubmed[A case of chronic pulmonary hypertension after fenfluramine intake]
Authors:  Gaul G, Blazek G, Deutsch E, Heeger H
Journal: Wien Klin Wochenschr

Pubmed[Modification of psychosocial adjustment by terminal disease]
Authors:  Heim E, Adler R, Moser A
Journal: Z Psychosom Med Psychoanal

PubmedPrimary pulmonary hypertension, a review.
Authors:  Widimský J
Journal: Cor Vasa

Pubmed[Severe adverse drug reactions among medical inpatients (author's transl)]
Authors:  Marty H, Winzenried P, Hess T, Lépine A, Stocker F, Hoigné R
Journal: Schweiz Rundsch Med Prax

PubmedPrimary pulmonary hypertension: follow-up of patients with and without anorectic drug intake.
Authors:  Mlczoch J, Probst P, Szeless S, Kaindl F
Journal: Cor Vasa

PubmedPrimary pulmonary hypertension.
Authors:  Fishman AP, Pietra GG
Journal: Annu Rev Med

Pubmed[Thrombocyte behavior in patients with "primary" pulmonary hypertension. Pathogenesis of aminorex-induced pulmonary hypertension]
Authors:  Mlczoch J
Journal: Acta Med Austriaca Suppl

PubmedPulmonary hypertension, "plexogenic pulmonary arteriopathy" and the appetite depressant drug aminorex: post or propter?
Authors:  Gurtner HP
Journal: Bull Eur Physiopathol Respir

PubmedLong term effects of the anorectic agent fenfluramine alone and in combination with aminorex on pulmonary and systemic circulation in the pig.
Authors:  Mlczoch J, Weir EK, Reeves JT, Grover RF
Journal: Basic Res Cardiol

PubmedHemodynamic effects of long term feeding of sympathomimetic amines to swine.
Authors:  Orr JA, Ungerer T, Seavey E, Bisgard GE, Will JA
Journal: J Environ Pathol Toxicol

Pubmed[Course and prognosis of primary pulmonary hypertension]
Authors:  Turina J, Wirz P, Krayenbühl HP
Journal: Schweiz Med Wochenschr

PubmedPulmonary vascular disease.
Authors:  Heath D, Smith P
Journal: Med Clin North Am

Pubmed[Reversible pulmonary arterial hypertension after medication of aminorexfumarate (author's transl)]
Authors:  Simon H, Felix R
Journal: Med Klin

PubmedRelease of platelet 5-hydroxytryptamine by some anorexic and other sympathomimetics and their acetyl derivatives.
Authors:  Friström S, Airaksinen MM, Halmekoski J
Journal: Acta Pharmacol Toxicol (Copenh)

Pubmed[Effect of chronic hypoxic pulmonary hypertension on the effect of aminorex on the lesser circulation]
Authors:  Credner C
Journal: Verh Dtsch Ges Inn Med

PubmedPulmonary hypertension related to aminorex intake. Histologic, ultrastructural, and morphometric studies of 37 cases in Switzerland.
Authors:  Widgren S
Journal: Curr Top Pathol

Pubmed[Late diagnosis of a Menocil-induced pulmonary hypertension]
Authors:  Hansen B, Lüllmann H, Schaefer J
Journal: Dtsch Med Wochenschr

Pubmed[Drug-induced primary vascular pulmonary hypertension. Contribution to its etiology and clinical course]
Authors:  Schnabel KH, Schulz V, Busch S, Just H
Journal: Med Welt

PubmedHow study of geographic epidemiology of disease can help in detection of adverse drug reactions.
Authors:  Stolley PD
Journal: Clin Pharmacol Ther

Pubmed[Anorexic preparations and primary pulmonary hypertension]
Authors:  Ugriumova MO
Journal: Ter Arkh

Pubmed[On the mechanism of action of aminorexfumarate (author's transl)]
Authors:  Schuster J
Journal: Arzneimittelforschung

Pubmed[Two-year peroral administration of aminorex in the dog. 2]
Authors:  Stepanek J, Zak F
Journal: Z Kardiol

Pubmed[Two-year peroral administration of aminorex in the dog. 1]
Authors:  Stepanek J, Zak F
Journal: Z Kardiol

PubmedAminorex and pulmonary circulation.
Authors:  Seiler KU
Journal: Arzneimittelforschung

PubmedProceedings: Epidemiological remarks. Discussion.
Authors:  Epstein FH
Journal: Pathol Microbiol (Basel)

PubmedProceedings: The epidemic of primary pulmonary hypertension in Europe.
Authors:  Lüthy E
Journal: Pathol Microbiol (Basel)

Pubmed[Proceedings: Pulmonary arterial hypertension in patients treated with appetite depressants in Switzerland]
Authors:  Widgren S
Journal: Verh Dtsch Ges Pathol

PubmedAminorex and the pulmonary circulation of rats fed on a high fat diet.
Authors:  Smith P, Heath D
Journal: Arzneimittelforschung

PubmedEffect of APMO on pulmonary and arterial blood pressure; a comparison with aminorex.
Authors:  Abdallah AH
Journal: Eur J Pharmacol

Pubmed[Evolution of primary vascular pulmonary hypertension following ingestion of aminorex fumarate (Menocil). Preliminary communication]
Authors:  Bass O, Gurtner HP
Journal: Schweiz Med Wochenschr

Pubmed[Pulmonary hypertension following chronic ingestion of aminorex in dogs. Preliminary communication]
Authors:  Stepanek J
Journal: Schweiz Med Wochenschr

Pubmed[Effect of chronic application of aminorex-fumarate on the pulmonary circulation of the rat]
Authors:  Engelhardt R, Kalbfleisch H
Journal: Arzneimittelforschung

PubmedPulmonary arterial pressure and structure in the patas monkey after prolonged administration of aminorex fumarate.
Authors:  Smith P, Heath D, Kay JM, Wright JS, McKendrick CS
Journal: Cardiovasc Res

Pubmed[Alteration of the acid-base equilibrium by the anorectic diphemethoxidine in comparison with the effect of amphetamine and aminorex]
Authors:  Stepanek J
Journal: Arch Int Pharmacodyn Ther

Pubmed[Apparently primary pulmonary arterial hypertension in a woman who had taken appetite depressants (Aminorex)]
Authors:  Berthou JD, Delahaye JP, Brune J, Dorsit G, Delaye J, Roques JC, Gonin A
Journal: Rev Tuberc Pneumol (Paris)

Pubmed[Changes in acid-base equilibrium caused by Aminorex and amphetamine in the dog]
Authors:  Stepanek J
Journal: Schweiz Med Wochenschr





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