acedapsone - Medical Dictionary

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acedapsone		Acetylated sulfone that is slowly metabolized to give long-term, low blood levels of dapsone. It has antimicrobial and antimalarial action, but is mainly used as a depot leprostatic agent. [ Books \| Images \| Discussion groups ]

Additional comments : (Acetyldiphenazonum, DADDS, Diacetyldapsone) See Also: Malaria, Leprosy Articles Relapses in multibacillary patients treated with multi-drug therapy until smear negativity: findings after twenty years. Authors: Norman G, Joseph G, Richard J Journal: Int J Lepr Other Mycobact Dis Letter to the Editor: Management of aplasia cutis congenita in a non-scalp location. Authors: Simman R Journal: Br J Plast Surg Effectiveness of multidrug therapy in multibacillary leprosy: a long-term follow-up of 34 multibacillary leprosy patients treated with multidrug regimens till skin smear negativity. Authors: Shaw IN, Christian M, Jesudasan K, Kurian N, Rao GS Journal: Lepr Rev Activation of diacetyldapsone and a preliminary evaluation of a cyclodextrin-diacetyldapsone complex in cultured lung cells. Authors: Nimbalkar D, Birudaraj R, Jones PR, Smith TJ Journal: Biotechnol Appl Biochem Relapse as histoid leprosy after receiving multidrug therapy (MDT); a report of three cases. Authors: Shaw IN, Ebenezer G, Rao GS, Natrajan MM, Balasundaram B Journal: Int J Lepr Other Mycobact Dis Prophylaxis--scope and limitations. Authors: Noordeen SK Journal: Lepr Rev Chemoprophylaxis is effective in the prevention of leprosy in endemic countries: a systematic review and meta-analysis. MILEP2 Study Group. Mucosal Immunology of Leprosy. Authors: Smith CM, Smith WC Journal: J Infect Trials of preventive therapy. Authors: Blanc LJ Journal: Int J Lepr Other Mycobact Dis The effect of acetylation and deacetylation on the disposition of dapsone and monoacetyl dapsone hydroxylamines in human erythrocytes in-vitro. Authors: Coleman MD, Pahal KK, Gardiner JM Journal: J Pharm Pharmacol Acetylation phenotype and genotype in aboriginal leprosy patients from the north-west region of Western Australia. Authors: Ilett KF, Chiswell GM, Spargo RM, Platt E, Minchin RF Journal: Pharmacogenetics [Bacteriologic study in patients with multibacillary leprosy treated with rifampicin and acedapsone] Authors: Olivares Sabournin R, González Segredo AB Journal: Rev Cubana Med Trop Early adventures in drug metabolism: 2. The absorption of drugs. Authors: Glazko AJ Journal: Ther Drug Monit [Automated determination of 4,4'-diaminodiphenylsulfone (DDS) and acetyl metabolites (MADDS and DADDS) in milk with the FAST-LC system] Authors: Brinkman MB, van Gend HW, Mattern EM Journal: Z Lebensm Unters Forsch Blood dapsone levels in leprosy patients treated with acedapsone. Authors: George J, Balakrishnan S Journal: Indian J Lepr Limited duration acedapsone prophylaxis in leprosy. Authors: Neelan PN, Sirumban P, Sivaprasad N Journal: Indian J Lepr The number of Mycobacterium leprae in the pretreatment biopsy-specimen does not determine the rate of response of patients with lepromatous leprosy to chemotherapy with acedapsone. Authors: Levy L, Shepard CC Journal: Lepr Rev Multidrug therapy for leprosy in Trinidad and Tobago: a preliminary report. Authors: Keeler RF Journal: Lepr Rev Activities of respository preparations of cycloguanil pamoate and 4,4'-diacetyldiaminodiphenylsulfone, alone and in combination, against infections with Plasmodium cynomolgi in rhesus monkeys. Authors: Schmidt LH, Rossan RN Journal: Antimicrob Agents Chemother Long-acting, repository antimalarial agents. Duration of protection in mice and monkeys following administration of pyrimethamine pamoate. Authors: Werbel LM, Jacobs RL, Steinkampf RW, Worth DF Journal: Am J Trop Med Hyg Chemoprophylaxis against leprosy with acedapsone. Authors: Neelan PN, Noordeen SK, Sivaprasad N Journal: Indian J Med Res A rabbit--in vitro system to evaluate drug action against Plasmodium falciparum. Authors: Mrema JE, Rieckmann KH Journal: Trans R Soc Trop Med Hyg Influence of sulphone therapy on lepromin reaction. Authors: Ramu G, Sengupta U, Desikan KV Journal: Lepr Rev Combined treatment for lepromatous leprosy. Authors: Ellard GA Journal: Lepr Rev Chemoprophylaxis against leprosy with acedapsone. An interim report. Authors: Noordeen SK, Neelan PN, Munaf A Journal: Lepr India Activity and effective serum level of repository sulphones (DADDS) in lepromatous leprosy. Authors: Anand LC, Rathore BS Journal: Lepr India Acedapsone in the prevention of leprosy: field trial in three high prevalence villages in Micronesia. Authors: Russell DA, Worth RM, Jano B, Fasal P, Shepard CC Journal: Am J Trop Med Hyg Acedapsone treatment of leprosy patients: response versus drug disposition. Authors: Peters JH, Murray JF, Gordon GR, Levy L, Russell DA, Scott GC, Vincin DR, Shepard CC Journal: Am J Trop Med Hyg Untreated leprosy: probability for shifts in Ridley-Jopling classification. Development of "flares", or disappearance of clinically apparent disease. Authors: Scott GC, Russell DA, Boughton CR, Vincin DR Journal: Int J Lepr Other Mycobact Dis Treatment failure in leprosy. Authors: Levy L Journal: Int J Lepr Other Mycobact Dis Experience with acedapsone (DADDS) in the therapeutic trial in New Guinea and the chemoprophylactic trial in Micronesia. Authors: Russell DA, Worth RM, Scott GC, Vincin DR, Jano B, Fasal P, Shepard CC Journal: Int J Lepr Other Mycobact Dis Susceptibility of Mycobacterium leprae to dapsone as a determinant of patient response to acedapsone. Authors: Levy L, Peters JH Journal: Antimicrob Agents Chemother Letter: Prevention of leprosy by acedapsone. Authors: Russell DA, Worth RM, Jano B, Fasal P, Shepard CC Journal: Lancet A preliminary report on a therapeutic trial with acedapsone in lepromatous leprosy. Authors: Ramanujam K, Iyer CG, Ramu G Journal: Lepr Rev Acedapsone (DADDS) treatment of leprosy patients in the Karimui of Papua New Guinea: status at six years. Authors: Russell DA, Shepard CC, McRae DH, Scott GC, Vincin DR Journal: Am J Trop Med Hyg Rifampin therapy of lepromatous leprosy. Authors: Journal: Am J Trop Med Hyg Acedapsone in the preventive treatment of leprosy. Authors: Russell DA, Worth RM, Jano B, Fasal P, Shepard CC Journal: Lepr Rev The death rate of Mycobacterium leprae during treatment of lepromatous leprosy with acedapsone (DADDS). Authors: Shepard CC, Levy L, Fasal P Journal: Am J Trop Med Hyg Acedapsone in leprosy treatment: trial in 68 active cases in Micronesia. Authors: Sloan NR, Worth RM, Jano B, Fasal P, Shepard CC Journal: Int J Lepr Other Mycobact Dis Acedapsone in leprosy chemoprophylaxis: field trial in three high-prevalence villages in Micronesia. Authors: Sloan NR, Worth RM, Jano B, Fasal P, Shepard CC Journal: Int J Lepr Other Mycobact Dis Repository acedapsone in leprosy chemoprophylaxis and treatment. Authors: Sloan NR, Worth RM, Jano B, Fasal P, Shepard CC Journal: Lancet A preliminary report on the use of the depot sulphone preparation acedapsone ("Hansolar") in the control of leprosy. Authors: Boughton CR, Scott GC, Russell DA, Vincin DR Journal: Med J Aust Respository drugs. IV. 4',4'''-Sulfonylbisacetanilide (Acedapsone, DADDS) and related sulfanilylanilides with prolonged antimalarial and antileprotic action. Authors: Elslager EF, Gavrilis ZB, Phillips AA, Worth DF Journal: J Med Chem

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