Dental Journals
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Topical 5% imiquimod for the therapy of actinic cheilitis.
Smith KJ, Germain M, Yeager J, Skelton H. - J Am Acad Dermatol. 2002 Oct;47(4):497-501
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BACKGROUND:
Tissue-destructive and more selective cytotoxic therapies are the main methods used
to treat actinic cheilitis. A topical immune stimulant, 5% imiquimod cream, has recently
been used for treatment of cutaneous epithelial malignancies including squamous cell
carcinoma in situ and basal cell carcinoma.
OBJECTIVE:
Our aim was to review the results
in patients who had been treated for actinic cheilitis with imiquimod cream.
METHODS:
A review identified 15 patients with biopsy-proven actinic cheilitis
who had been treated with topical imiquimod 3 times weekly for 4 to 6 weeks.
All patients with histories consistent with facial herpes simplex or documented
prior facial herpes simplex eruptions were treated with oral valcyclovir,
1 g/d, during imiquimod therapy. RESULTS: All 15 patients showed clinical
clearing of their actinic cheilitis at 4 weeks after discontinuation of
the topical imiquimod. Sixty percent of the patients experienced a moderate
to marked increased local reaction consisting of increased erythema, induration,
and erosions or ulcerations, which in some cases continued through the period
of therapy.
CONCLUSION:
Imiquimod appears to have a role in the treatment of
actinic cheilitis. However, the dose and duration of therapy, as well as the
long-term efficacy, need to be established; and local reactions are to be
expected and may not improve during therapy.
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