Dental Journals
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The efficacy and safety of 50 mg penicillin G potassium troches for recurrent aphthous ulcers.
Kerr AR, Drexel CA, Spielman AI. - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003 Dec;96(6):685-94.
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PURPOSE:
To determine both the efficacy and safety of the topical application of
50 mg penicillin G potassium troches (Cankercillin) in the treatment of minor
recurrent aphthous stomatitis (RAS).
STUDY DESIGN:
The investigation used a
phase 2 double-blind, randomized placebo-controlled trial with a no-treatment
arm. Subjects with minor aphthous ulcers of duration <48 hours were followed for
1 week. The primary endpoint for efficacy was time (days) to complete ulcer
resolution, and the secondary endpoint was time (days) to complete pain relief.
RESULTS:
Thirty-one, 33, and 36 subjects were randomized to the active
treatment, placebo, and no-treatment arms, respectively. Baseline findings were
heterogeneous across arms. Subjects who received penicillin G treatment had
complete ulcer healing and pain relief significantly earlier than those in the
placebo and no-treatment arms. No allergic reactions were observed.
CONCLUSIONS:
Topical penicillin G, by mechanisms which remain unclear, reduces the time of
healing and pain relief of minor aphthous ulcers with minimal safety concerns.
Larger phase 3 studies are necessary to confirm these findings.
Full Text
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